Transcription factors with Perturb-seq knockdown data for ENSG00000291224. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291224 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291224, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:9,703,572–9,705,701 | 281.8 kb | Distal (>10kb) Multiome | 664 | |
| chr3:9,727,013–9,727,518 | 259.7 kb | Distal (>10kb) Multiome | 264 | |
| chr3:9,730,724–9,732,470 | 255.6 kb | Distal (>10kb) Multiome | 934 | |
| chr3:9,749,252–9,750,525 | 236.9 kb | Distal (>10kb) Multiome | 873 | |
| chr3:9,769,503–9,770,124 | 217.0 kb | Distal (>10kb) Multiome | 504 | |
| chr3:9,792,176–9,793,536 | 194.1 kb | Distal (>10kb) Multiome | 915 | |
| chr3:9,809,609–9,810,744 | 176.8 kb | Distal (>10kb) Multiome | 437 | |
| chr3:9,843,116–9,844,397 | 142.9 kb | Distal (>10kb) Multiome | 787 | |
| chr3:9,862,465–9,863,231 | 124.1 kb | Distal (>10kb) Multiome | 581 | |
| chr3:9,890,247–9,891,058 | 96.3 kb | Distal (>10kb) Multiome | 969 | |
| chr3:9,902,504–9,903,128 | 84.1 kb | Distal (>10kb) Multiome | 396 | |
| chr3:9,914,983–9,916,160 | 71.6 kb | Distal (>10kb) Multiome | 668 | |
| chr3:9,916,644–9,917,412 | 69.8 kb | Distal (>10kb) Multiome | 519 | |
| chr3:9,932,470–9,934,327 | 54.1 kb | Distal (>10kb) Multiome | 1035 | |
| chr3:9,946,152–9,947,739 | 40.3 kb | Distal (>10kb) Multiome | 898 | |
| chr3:9,951,898–9,952,503 | 34.6 kb | Distal (>10kb) Multiome | 484 | |
| chr3:9,986,547–9,987,409 | 29 bp | At TSS Multiome | 907 | |
| chr3:10,008,678–10,009,458 | 22.2 kb | Distal (>10kb) Multiome | 240 | |
| chr3:10,010,580–10,011,700 | 24.3 kb | Distal (>10kb) Multiome | 540 | |
| chr3:10,025,904–10,026,762 | 39.5 kb | Distal (>10kb) Multiome | 871 | |
| chr3:10,115,394–10,116,145 | 128.8 kb | Distal (>10kb) Multiome | 809 | |
| chr3:10,141,441–10,142,425 | 154.9 kb | Distal (>10kb) Multiome | 894 | |
| chr3:10,164,557–10,165,625 | 178.0 kb | Distal (>10kb) Multiome | 718 | |
| chr3:10,226,242–10,226,711 | 239.6 kb | Distal (>10kb) Multiome | 88 | |
| chr3:10,234,612–10,235,203 | 248.1 kb | Distal (>10kb) Multiome | 122 | |
| chr3:10,248,095–10,249,643 | 261.5 kb | Distal (>10kb) Multiome | 892 | |
| chr3:10,263,882–10,264,353 | 277.2 kb | Distal (>10kb) Multiome | 139 |
Genomic view of the ENSG00000291224 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.