Predicted to enable metal ion binding activity and nuclease activity. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TATDN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TATDN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TATDN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:9,951,898–9,952,503 | 296.2 kb | Distal (>10kb) Multiome | 484 | |
| chr3:9,986,547–9,987,409 | 261.5 kb | Distal (>10kb) Multiome | 907 | |
| chr3:10,008,678–10,009,458 | 239.3 kb | Distal (>10kb) Multiome | 240 | |
| chr3:10,010,580–10,011,700 | 237.3 kb | Distal (>10kb) Multiome | 540 | |
| chr3:10,025,904–10,026,762 | 222.1 kb | Distal (>10kb) Multiome | 871 | |
| chr3:10,115,394–10,116,145 | 132.8 kb | Distal (>10kb) Multiome | 809 | |
| chr3:10,141,441–10,142,425 | 106.6 kb | Distal (>10kb) Multiome | 894 | |
| chr3:10,164,557–10,165,625 | 83.5 kb | Distal (>10kb) Multiome | 718 | |
| chr3:10,226,242–10,226,711 | 21.9 kb | Distal (>10kb) Multiome | 88 | |
| chr3:10,234,612–10,235,203 | 13.5 kb | Distal (>10kb) Multiome | 122 | |
| chr3:10,248,095–10,249,643 | 32 bp | At TSS Multiome | 892 | |
| chr3:10,263,882–10,264,353 | 15.6 kb | Distal (>10kb) Multiome | 139 | |
| chr3:10,316,093–10,316,808 | 68.1 kb | Distal (>10kb) Multiome | 50 | |
| chr3:10,320,481–10,321,504 | 72.7 kb | Distal (>10kb) Multiome | 955 |
Genomic view of the TATDN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.