NR2F6

nuclear receptor subfamily 2 group F member 6 | EAR-2, EAR2, ERBAL2

Enables DNA-binding transcription factor activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 DE-1.56

Biological processes 27 terms

DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)cell differentiation (GO:0030154)chromatin (GO:0000785)intracellular receptor signaling pathway (GO:0030522)mitochondrion (GO:0005739)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nervous system development (GO:0007399)nuclear receptor activity (GO:0004879)nuclear speck (GO:0016607)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)sequence-specific DNA binding (GO:0043565)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating NR2F6 0 TFs

Transcription factors with Perturb-seq knockdown data for NR2F6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NR2F6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NR2F6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NR2F6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:17,074,934–17,076,532	170.3 kb	Distal (>10kb) Multiome	890
chr19:17,209,430–17,210,427	36.1 kb	Distal (>10kb) Multiome	245
chr19:17,215,005–17,215,979	30.4 kb	Distal (>10kb) Multiome	897
chr19:17,225,705–17,226,889	19.5 kb	Distal (>10kb) Multiome	870
chr19:17,234,748–17,236,650	10.0 kb	Distal (>10kb) Multiome	612
chr19:17,244,035–17,244,563	at TSS	At TSS	488
chr19:17,244,882–17,247,104	213 bp	At TSS Multiome	862
chr19:17,247,935–17,248,860	2.7 kb	Proximal (<10kb) Multiome	588
chr19:17,266,931–17,267,755	21.3 kb	Distal (>10kb) Multiome	720
chr19:17,281,537–17,283,120	36.9 kb	Distal (>10kb) Multiome	669
chr19:17,292,242–17,293,049	46.8 kb	Distal (>10kb) Multiome	513
chr19:17,302,721–17,303,771	57.5 kb	Distal (>10kb) Multiome	636
chr19:17,305,286–17,306,514	59.8 kb	Distal (>10kb) Multiome	947
chr19:17,309,159–17,310,151	63.6 kb	Distal (>10kb) Multiome	741
chr19:17,327,532–17,329,548	82.1 kb	Distal (>10kb) Multiome	370
chr19:17,334,287–17,335,052	88.9 kb	Distal (>10kb) Multiome	870
chr19:17,336,574–17,338,240	91.5 kb	Distal (>10kb) Multiome	924
chr19:17,340,311–17,341,226	94.7 kb	Distal (>10kb) Multiome	419
chr19:17,390,414–17,391,521	145.3 kb	Distal (>10kb) Multiome	615
chr19:17,394,998–17,395,433	149.3 kb	Distal (>10kb) Multiome	403
chr19:17,398,863–17,399,537	153.3 kb	Distal (>10kb) Multiome	132
chr19:17,403,087–17,404,355	157.6 kb	Distal (>10kb) Multiome	211
chr19:17,419,503–17,420,821	174.0 kb	Distal (>10kb) Multiome	869
chr19:17,424,865–17,425,411	179.2 kb	Distal (>10kb) Multiome	328
chr19:17,448,174–17,448,841	202.7 kb	Distal (>10kb) Multiome	392
chr19:17,468,858–17,470,905	224.2 kb	Distal (>10kb) Multiome	743
chr19:17,488,739–17,489,689	243.2 kb	Distal (>10kb) Multiome	381
chr19:17,511,113–17,512,592	265.6 kb	Distal (>10kb) Multiome	1021
chr19:17,538,878–17,540,353	293.9 kb	Distal (>10kb) Multiome	725

Genome Browser

Genomic view of the NR2F6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.