chr18 : 3,610,182 – 3,610,667

485 bp 99 TFs 4 linked genes

This 485 bp open chromatin element is linked to 4 target genes and is bound by 99 transcription factors.

Linked Genes

4 genes

Gene	Dist. to TSS	Distance	Link type
DLGAP1-AS2	6.2 kb	Proximal	Proximity
DLGAP1-AS1	16.2 kb	Distal	Multiome
TGIF1	162.8 kb	Distal	Multiome+HiCAR
MYL12B	348.2 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

99 transcription factors

AFF1 2 datasets

ChIP K-562 ENCSR426URK.AFF1.K-562 485 bp overlap

ChIP K-562 ENCSR241LIH.AFF1.K-562 438 bp overlap

AFF4 1 dataset

ChIP HCT-116 GSE47938.AFF4.HCT-116 201 bp overlap

APC 1 dataset

ChIP HCT-116 GSE103894.APC.HCT-116 485 bp overlap

ARID2 3 datasets

ChIP Aska-SS GSE108025.ARID2.Aska-SS 320 bp overlap

ChIP Aska-SS_shSSX GSE108025.ARID2.Aska-SS_shSSX 405 bp overlap

ChIP BIN-67_lentivirus-SMARCA4 GSE117734.ARID2.BIN-67_lentivirus-SMARCA4 455 bp overlap

ARNT 1 dataset

ChIP K-562 ENCSR613NUC.ARNT.K-562 331 bp overlap

BCL3 1 dataset

ChIP A-549 ENCSR000BQH.BCL3.A-549 188 bp overlap

BRD3 1 dataset

ChIP K-562_DMSO-IFNG GSE138084.BRD3.K-562_DMSO-IFNG 295 bp overlap

BRD4 6 datasets

ChIP HCT-116 GSE73319.BRD4.HCT-116 485 bp overlap

ChIP HCT-116 GSE57628.BRD4.HCT-116 157 bp overlap

ChIP K-562_DMSO GSE138084.BRD4.K-562_DMSO 312 bp overlap

ChIP K-562_iBET-BD2 GSE138084.BRD4.K-562_iBET-BD2 234 bp overlap

ChIP K-562_iBET-BD2-IFNG GSE138084.BRD4.K-562_iBET-BD2-IFNG 203 bp overlap

ChIP SW480 GSE73319.BRD4.SW480 167 bp overlap

CDX2 2 datasets

Motif DE_12h DE_12h-CDX2_MA0465.3 8 bp overlap

Motif DE_60h DE_60h-CDX2_MA0465.3 8 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF031ISE 196 bp overlap

DNMT1 1 dataset

ChIP K-562 ENCSR987PBI.DNMT1.K-562 246 bp overlap

DPF2 1 dataset

ChIP BIN-67_lentivirus-SMARCA4-K785R GSE117734.DPF2.BIN-67_lentivirus-SMARCA4-K785R 197 bp overlap

E2F8 1 dataset

ChIP K-562 ENCSR953DVM.E2F8.K-562 485 bp overlap

ELF4 1 dataset

ChIP K-562 ENCSR638QHV.ELF4.K-562 352 bp overlap

ETV5 1 dataset

ChIP K562 ENCFF336FFA 322 bp overlap

FOS 1 dataset

ChIP HCT-116_A7A GSE152144.FOS.HCT-116_A7A 372 bp overlap

FOXD2 2 datasets

Motif DE_12h DE_12h-FOXD2_MA0847.4 11 bp overlap

Motif DE_60h DE_60h-FOXD2_MA0847.4 11 bp overlap

FOXD3 2 datasets

Motif DE_12h DE_12h-FOXD3_MA0041.3 14 bp overlap

Motif DE_60h DE_60h-FOXD3_MA0041.3 14 bp overlap

FOXF2 2 datasets

Motif DE_12h DE_12h-FOXF2_MA0030.2 9 bp overlap

Motif DE_60h DE_60h-FOXF2_MA0030.2 9 bp overlap

FOXH1 2 datasets

Motif DE_12h DE_12h-FOXH1_MA0479.2 8 bp overlap

Motif DE_60h DE_60h-FOXH1_MA0479.2 8 bp overlap

FOXK1 2 datasets

Motif DE_12h DE_12h-FOXK1_MA0852.3 7 bp overlap

Motif DE_60h DE_60h-FOXK1_MA0852.3 7 bp overlap

FOXK2 2 datasets

Motif DE_12h DE_12h-FOXK2_MA1103.3 7 bp overlap

Motif DE_60h DE_60h-FOXK2_MA1103.3 7 bp overlap

FOXL1 2 datasets

Motif DE_12h DE_12h-FOXL1_MA0033.2 7 bp overlap

Motif DE_60h DE_60h-FOXL1_MA0033.2 7 bp overlap

FOXO4 2 datasets

Motif DE_12h DE_12h-FOXO4_MA0848.1 7 bp overlap

Motif DE_60h DE_60h-FOXO4_MA0848.1 7 bp overlap

FOXO6 2 datasets

Motif DE_12h DE_12h-FOXO6_MA0849.1 7 bp overlap

Motif DE_60h DE_60h-FOXO6_MA0849.1 7 bp overlap

FOXP2 2 datasets

Motif DE_12h DE_12h-FOXP2_MA0593.2 9 bp overlap

Motif DE_60h DE_60h-FOXP2_MA0593.2 9 bp overlap

FOXP3 2 datasets

Motif DE_12h DE_12h-FOXP3_MA0850.1 7 bp overlap

Motif DE_60h DE_60h-FOXP3_MA0850.1 7 bp overlap

Foxf1 2 datasets

Motif DE_12h DE_12h-Foxf1_MA1606.2 7 bp overlap

Motif DE_60h DE_60h-Foxf1_MA1606.2 7 bp overlap

Foxo1 2 datasets

Motif DE_12h DE_12h-Foxo1_MA0480.3 7 bp overlap

Motif DE_60h DE_60h-Foxo1_MA0480.3 7 bp overlap

Foxo3 2 datasets

Motif DE_12h DE_12h-Foxo3_MA0157.4 7 bp overlap

Motif DE_60h DE_60h-Foxo3_MA0157.4 7 bp overlap

Foxq1 2 datasets

Motif DE_12h DE_12h-Foxq1_MA0040.2 10 bp overlap

Motif DE_60h DE_60h-Foxq1_MA0040.2 10 bp overlap

GATA4 1 dataset

ChIP A-549 GSE85002.GATA4.A-549 182 bp overlap

GATA6 1 dataset

ChIP DE_D2 S55-DE-d2-GATA6-exp2 324 bp overlap

HAND2 1 dataset

Motif DE_12h DE_12h-HAND2_MA1638.2 6 bp overlap

HDGF 1 dataset

ChIP K-562 ENCSR197ALX.HDGF.K-562 227 bp overlap

Hand1 2 datasets

Motif DE_12h DE_12h-Hand1_MA2123.1 9 bp overlap

Motif DE_60h DE_60h-Hand1_MA2123.1 9 bp overlap

Hmx1 1 dataset

Motif DE_60h DE_60h-Hmx1_MA0896.2 9 bp overlap

Hmx3 1 dataset

Motif DE_60h DE_60h-Hmx3_MA0898.2 9 bp overlap

ISL2 1 dataset

Motif DE_60h DE_60h-ISL2_MA0914.2 6 bp overlap

JUN 1 dataset

ChIP HAEC_oxpapc_4h GSE89970.JUN.HAEC_oxpapc_4h 88 bp overlap

KDM5B 1 dataset

ChIP K-562 ENCSR000AQA.KDM5B.K-562 390 bp overlap

Lef1 2 datasets

Motif DE_12h DE_12h-Lef1_MA0768.3 8 bp overlap

Motif DE_60h DE_60h-Lef1_MA0768.3 8 bp overlap

MAX 2 datasets

ChIP NCI-H2171 GSE36354.MAX.NCI-H2171 293 bp overlap

ChIP NCI-H2171 GSE41105.MAX.NCI-H2171 211 bp overlap

MED1 6 datasets

ChIP HCT-116 GSE121798.MED1.HCT-116 331 bp overlap

ChIP HCT-116_shLuc GSE121798.MED1.HCT-116_shLuc 355 bp overlap

ChIP HCT-116_shLuc_thaps GSE121798.MED1.HCT-116_shLuc_thaps 362 bp overlap

ChIP HCT-116_thaps GSE121798.MED1.HCT-116_thaps 424 bp overlap

ChIP HUVEC-C_siCTL GSE124892.MED1.HUVEC-C_siCTL 321 bp overlap

ChIP HUVEC-C_siERG GSE124892.MED1.HUVEC-C_siERG 390 bp overlap

MED26 1 dataset

ChIP HCT-116_aux GSE121355.MED26.HCT-116_aux 160 bp overlap

MEIS1 3 datasets

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

MLLT1 2 datasets

ChIP K-562 ENCSR107GRP.MLLT1.K-562 465 bp overlap

ChIP K-562 ENCSR675LRO.MLLT1.K-562 395 bp overlap

MPHOSPH8 1 dataset

ChIP H9 GSE95374.MPHOSPH8.H9 163 bp overlap

MTA3 1 dataset

ChIP K-562 ENCSR180NCY.MTA3.K-562 388 bp overlap

MYBL2 1 dataset

ChIP A-673 GSE119971.MYBL2.A-673 212 bp overlap

MYC 1 dataset

ChIP NCI-H2171 GSE36354.MYC.NCI-H2171 327 bp overlap

MYNN 1 dataset

ChIP K-562 ENCSR737LTZ.MYNN.K-562 199 bp overlap

NCAPH2 1 dataset

ChIP IMR-90_FLAG_OIS GSE118494.NCAPH2.IMR-90_FLAG_OIS 485 bp overlap

NCOR1 1 dataset

ChIP K-562 ENCSR798ILC.NCOR1.K-562 268 bp overlap

NEUROD1 2 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 257 bp overlap

ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 368 bp overlap

NEUROG2 1 dataset

Motif DE_12h DE_12h-NEUROG2_MA1642.2 7 bp overlap

NFATC3 2 datasets

ChIP K-562 ENCSR051OUX.NFATC3.K-562 485 bp overlap

ChIP K-562 ENCSR670FDA.NFATC3.K-562 485 bp overlap

NFE2L2 1 dataset

ChIP K-562 ENCSR485GKE.NFE2L2.K-562 162 bp overlap

NFXL1 1 dataset

ChIP K562 ENCFF898RYR 345 bp overlap

NUTM1 1 dataset

ChIP NUT_DMSO GSE133122.NUTM1.NUT_DMSO 365 bp overlap

Nkx3-2 1 dataset

Motif DE_60h DE_60h-Nkx3-2_MA0122.4 10 bp overlap

PHIP 1 dataset

ChIP HCT-116_ab833 GSE101646.PHIP.HCT-116_ab833 293 bp overlap

PKNOX2 2 datasets

Motif DE_12h DE_12h-PKNOX2_MA0783.1 12 bp overlap

Motif DE_60h DE_60h-PKNOX2_MA0783.1 12 bp overlap

POLR2A 7 datasets

ChIP H1 ENCFF833NJP 392 bp overlap

ChIP HeLa-S3 ENCFF045HUU 433 bp overlap

ChIP HeLa-S3 ENCFF045HUU 187 bp overlap

ChIP K562 ENCFF214YGX 485 bp overlap

ChIP K562 ENCFF262YXJ 299 bp overlap

ChIP K562 ENCFF514URW 375 bp overlap

ChIP Panc1 ENCFF290KAB 316 bp overlap

POLR2G 1 dataset

ChIP HepG2 ENCFF508UTS 310 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 346 bp overlap

Ptf1A 1 dataset

Motif DE_12h DE_12h-Ptf1A_MA1618.2 9 bp overlap

RBFOX2 4 datasets

ChIP K-562 GSE120104.RBFOX2.K-562 397 bp overlap

ChIP K-562 ENCSR822LBD.RBFOX2.K-562 361 bp overlap

ChIP K562 ENCFF196WTG 485 bp overlap

ChIP K562 ENCFF967GRF 485 bp overlap

RBM22 2 datasets

ChIP K-562 ENCSR848AOP.RBM22.K-562 189 bp overlap

ChIP K-562 GSE120104.RBM22.K-562 204 bp overlap

REST 2 datasets

Motif DE_12h DE_12h-REST_MA0138.3 20 bp overlap

Motif DE_60h DE_60h-REST_MA0138.3 20 bp overlap

SMAD2 3 datasets

Motif DE_12h DE_12h-SMAD2_MA1964.2 6 bp overlap

Motif DE_60h DE_60h-SMAD2_MA1964.2 6 bp overlap

ChIP endoderm GSE29422.SMAD2.endoderm 218 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 485 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 485 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 350 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 353 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 429 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 344 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 368 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 392 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 186 bp overlap

SMARCA4 1 dataset

ChIP BIN-67_lentivirus-SMARCA4-K785R GSE117734.SMARCA4.BIN-67_lentivirus-SMARCA4-K785R 400 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 319 bp overlap

SOX6 1 dataset

ChIP K-562 ENCSR788RSW.SOX6.K-562 400 bp overlap

SUPT5H 1 dataset

ChIP HCT-116_pThr806 GSE138548.SUPT5H.HCT-116_pThr806 469 bp overlap

SUPT6H 1 dataset

ChIP HCT-116 GSE130509.SUPT6H.HCT-116 449 bp overlap

TBX1 2 datasets

Motif DE_12h DE_12h-TBX1_MA0805.1 8 bp overlap

Motif DE_60h DE_60h-TBX1_MA0805.1 8 bp overlap

TBX15 2 datasets

Motif DE_12h DE_12h-TBX15_MA0803.1 8 bp overlap

Motif DE_60h DE_60h-TBX15_MA0803.1 8 bp overlap

TBX18 2 datasets

Motif DE_12h DE_12h-TBX18_MA1565.2 9 bp overlap

Motif DE_60h DE_60h-TBX18_MA1565.2 9 bp overlap

TBX2 2 datasets

Motif DE_12h DE_12h-TBX2_MA0688.2 9 bp overlap

Motif DE_60h DE_60h-TBX2_MA0688.2 9 bp overlap

TBX21 2 datasets

Motif DE_12h DE_12h-TBX21_MA0690.3 10 bp overlap

Motif DE_60h DE_60h-TBX21_MA0690.3 10 bp overlap

TBX3 2 datasets

Motif DE_12h DE_12h-TBX3_MA1566.3 9 bp overlap

Motif DE_60h DE_60h-TBX3_MA1566.3 9 bp overlap

TBX4 2 datasets

Motif DE_12h DE_12h-TBX4_MA0806.1 8 bp overlap

Motif DE_60h DE_60h-TBX4_MA0806.1 8 bp overlap

TBX5 2 datasets

Motif DE_12h DE_12h-TBX5_MA0807.1 8 bp overlap

Motif DE_60h DE_60h-TBX5_MA0807.1 8 bp overlap

TGIF1 2 datasets

Motif DE_12h DE_12h-TGIF1_MA0796.1 12 bp overlap

Motif DE_60h DE_60h-TGIF1_MA0796.1 12 bp overlap

TGIF2 2 datasets

Motif DE_12h DE_12h-TGIF2_MA0797.1 12 bp overlap

Motif DE_60h DE_60h-TGIF2_MA0797.1 12 bp overlap

THAP7 1 dataset

ChIP K562 ENCFF018XUY 316 bp overlap

THRB 1 dataset

ChIP K562 ENCFF620NFN 229 bp overlap

TWIST1 1 dataset

Motif DE_12h DE_12h-TWIST1_MA1123.3 8 bp overlap

ZBTB33 1 dataset

ChIP K-562 ENCSR876GXA.ZBTB33.K-562 276 bp overlap

ZEB1 1 dataset

ChIP MIA-PaCa-2 GSE88734.ZEB1.MIA-PaCa-2 423 bp overlap

ZEB2 1 dataset

ChIP K-562 ENCSR004GKA.ZEB2.K-562 432 bp overlap

ZNF592 1 dataset

ChIP K-562 ENCSR249BHQ.ZNF592.K-562 433 bp overlap

ZNF764 1 dataset

ChIP K-562 ENCSR023OOE.ZNF764.K-562 424 bp overlap

ZNF770 1 dataset

ChIP HEK293 ENCSR242BGR.ZNF770.HEK293 180 bp overlap

ZSCAN32 1 dataset

ChIP K562 ENCFF960API 271 bp overlap