Enables chromatin binding activity; histone reader activity; and methylated histone binding activity. Involved in negative regulation of gene expression via chromosomal CpG island methylation and transposable element silencing by heterochromatin formation. Located in several cellular components, including cytosol; heterochromatin; and nuclear lumen. Part of nucleosome. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MPHOSPH8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MPHOSPH8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MPHOSPH8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:19,601,659–19,602,741 | 31.6 kb | Distal (>10kb) Multiome | 619 | |
| chr13:19,633,184–19,634,576 | 124 bp | At TSS Multiome | 757 | |
| chr13:19,782,029–19,783,375 | 149.3 kb | Distal (>10kb) Multiome | 684 | |
| chr13:19,862,481–19,865,034 | 230.0 kb | Distal (>10kb) Multiome | 795 |
Genomic view of the MPHOSPH8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.