Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NFXL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFXL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFXL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:47,836,414–47,838,176 | 77.7 kb | Distal (>10kb) Multiome | 604 | |
| chr4:47,907,898–47,908,200 | 6.4 kb | Proximal (<10kb) | 7 | |
| chr4:47,913,703–47,915,119 | 91 bp | At TSS Multiome | 856 | |
| chr4:47,922,368–47,922,782 | 7.8 kb | Proximal (<10kb) | 14 | |
| chr4:47,926,660–47,927,239 | 12.3 kb | Distal (>10kb) Multiome | 243 | |
| chr4:48,015,887–48,017,756 | 102.1 kb | Distal (>10kb) Multiome | 714 | |
| chr4:48,126,799–48,128,119 | 213.2 kb | Distal (>10kb) Multiome | 526 |
Genomic view of the NFXL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.