SUPT6H

SPT6 homolog, histone chaperone and transcription elongation factor | KIAA0162, SPT6H

Enables histone binding activity. Involved in positive regulation of transcription elongation by RNA polymerase II and transcription elongation-coupled chromatin remodeling. Predicted to be located in nucleoplasm. Predicted to be part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-10

Biological processes 20 terms

DNA binding (GO:0003677)RNA binding (GO:0003723)histone binding (GO:0042393)histone binding (GO:0042393)nucleic acid binding (GO:0003676)nucleoplasm (GO:0005654)nucleosome binding (GO:0031491)nucleosome organization (GO:0034728)nucleus (GO:0005634)protein binding (GO:0005515)regulation of isotype switching (GO:0045191)regulation of isotype switching (GO:0045191)regulation of muscle cell differentiation (GO:0051147)regulation of muscle cell differentiation (GO:0051147)transcription elongation by RNA polymerase II (GO:0006368)transcription elongation by RNA polymerase II (GO:0006368)transcription elongation by RNA polymerase II (GO:0006368)transcription elongation factor complex (GO:0008023)transcription elongation-coupled chromatin remodeling (GO:0140673)transcription elongation-coupled chromatin remodeling (GO:0140673)

Expression (TPM)

TFs regulating SUPT6H 0 TFs

Transcription factors with Perturb-seq knockdown data for SUPT6H. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUPT6H upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SUPT6H

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUPT6H, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:28,371,118–28,372,519	290.7 kb	Distal (>10kb) Multiome	532
chr17:28,381,316–28,381,844	280.6 kb	Distal (>10kb) Multiome	159
chr17:28,405,673–28,406,384	256.2 kb	Distal (>10kb) Multiome	591
chr17:28,466,531–28,467,034	195.4 kb	Distal (>10kb) Multiome	179
chr17:28,551,965–28,553,140	109.6 kb	Distal (>10kb) Multiome	557
chr17:28,570,861–28,571,983	90.6 kb	Distal (>10kb) Multiome	701
chr17:28,576,649–28,577,524	85.2 kb	Distal (>10kb) Multiome	652
chr17:28,598,491–28,599,842	63.1 kb	Distal (>10kb) Multiome	810
chr17:28,621,936–28,622,562	39.9 kb	Distal (>10kb) Multiome	55
chr17:28,644,541–28,645,596	17.0 kb	Distal (>10kb) Multiome	795
chr17:28,661,635–28,662,527	70 bp	At TSS Multiome	809
chr17:28,710,720–28,712,813	49.2 kb	Distal (>10kb) Multiome	892
chr17:28,717,030–28,718,784	55.7 kb	Distal (>10kb) Multiome	492
chr17:28,718,918–28,720,313	57.6 kb	Distal (>10kb) Multiome	927
chr17:28,724,652–28,729,474	64.8 kb	Distal (>10kb) Multiome	1286
chr17:28,743,083–28,744,926	81.9 kb	Distal (>10kb) Multiome	991
chr17:28,745,076–28,746,436	83.4 kb	Distal (>10kb) Multiome	568
chr17:28,749,859–28,750,549	88.0 kb	Distal (>10kb) Multiome	550
chr17:28,811,615–28,812,945	150.3 kb	Distal (>10kb) Multiome	699
chr17:28,842,307–28,843,098	180.6 kb	Distal (>10kb) Multiome	717
chr17:28,854,460–28,855,289	192.7 kb	Distal (>10kb) Multiome	780
chr17:28,896,962–28,898,028	235.4 kb	Distal (>10kb) Multiome	846
chr17:28,902,302–28,903,488	240.8 kb	Distal (>10kb) Multiome	967
chr17:28,950,281–28,952,708	289.5 kb	Distal (>10kb) Multiome	989

Genome Browser

Genomic view of the SUPT6H locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.