The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for MYL12B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYL12B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYL12B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:3,012,394–3,013,832 | 248.8 kb | Distal (>10kb) Multiome | 816 | |
| chr18:3,245,709–3,246,515 | 16.0 kb | Distal (>10kb) Multiome | 627 | |
| chr18:3,246,619–3,248,313 | 14.6 kb | Distal (>10kb) Multiome | 1018 | |
| chr18:3,261,342–3,262,799 | 127 bp | At TSS Multiome | 929 | |
| chr18:3,296,788–3,297,724 | 35.3 kb | Distal (>10kb) Multiome | 828 | |
| chr18:3,346,756–3,347,972 | 85.2 kb | Distal (>10kb) Multiome | 44 | |
| chr18:3,447,486–3,448,604 | 186.1 kb | Distal (>10kb) Multiome | 938 | |
| chr18:3,448,748–3,450,993 | 187.9 kb | Distal (>10kb) Multiome | 909 | |
| chr18:3,498,885–3,499,424 | 237.2 kb | Distal (>10kb) Multiome | 144 | |
| chr18:3,553,601–3,555,390 | 292.2 kb | Distal (>10kb) Multiome | 275 | |
| chr18:3,593,642–3,595,153 | 332.0 kb | Distal (>10kb) Multiome HiCAR | 832 | |
| chr18:3,602,775–3,604,355 | 341.1 kb | Distal (>10kb) Multiome HiCAR | 903 | |
| chr18:3,610,182–3,610,667 | 348.2 kb | Distal (>10kb) Multiome HiCAR | 99 | |
| chr18:3,665,799–3,666,586 | 404.1 kb | Distal (>10kb) Multiome HiCAR | 692 |
Genomic view of the MYL12B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.