Transcription factors with Perturb-seq knockdown data for DLGAP1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLGAP1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLGAP1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:3,261,342–3,262,799 | 332.1 kb | Distal (>10kb) Multiome HiCAR | 929 | |
| chr18:3,296,788–3,297,724 | 296.7 kb | Distal (>10kb) Multiome HiCAR | 828 | |
| chr18:3,346,756–3,347,972 | 246.8 kb | Distal (>10kb) Multiome | 44 | |
| chr18:3,447,486–3,448,604 | 145.9 kb | Distal (>10kb) Multiome HiCAR | 938 | |
| chr18:3,448,748–3,450,993 | 144.1 kb | Distal (>10kb) Multiome HiCAR | 909 | |
| chr18:3,498,885–3,499,424 | 94.9 kb | Distal (>10kb) Multiome | 144 | |
| chr18:3,553,601–3,555,390 | 39.8 kb | Distal (>10kb) Multiome | 275 | |
| chr18:3,585,023–3,585,347 | 8.8 kb | Proximal (<10kb) | 204 | |
| chr18:3,585,663–3,586,119 | 8.0 kb | Proximal (<10kb) | 520 | |
| chr18:3,593,393–3,593,533 | 616 bp | At TSS | 255 | |
| chr18:3,593,642–3,595,153 | 19 bp | At TSS Multiome | 832 | |
| chr18:3,599,365–3,599,722 | 5.2 kb | Proximal (<10kb) | 54 | |
| chr18:3,602,454–3,602,622 | 8.3 kb | Proximal (<10kb) | 42 | |
| chr18:3,602,775–3,604,355 | 9.1 kb | Proximal (<10kb) Multiome | 903 | |
| chr18:3,610,182–3,610,667 | 16.2 kb | Distal (>10kb) Multiome | 99 | |
| chr18:3,665,799–3,666,586 | 72.1 kb | Distal (>10kb) Multiome HiCAR | 692 | |
| chr18:3,771,119–3,771,961 | 177.3 kb | Distal (>10kb) Multiome | 539 |
Genomic view of the DLGAP1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.