chr15:63,434,760–63,435,736

chr15 : 63,434,760 – 63,435,736

976 bp 102 TFs 6 linked genes

This 976 bp open chromatin element is linked to 6 target genes and is bound by 102 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
CA12		53.2 kb	Distal	Multiome
USP3		69.6 kb	Distal	Multiome
APH1B		157.4 kb	Distal	Multiome
USP3-AS1		165.8 kb	Distal	Multiome
RAB8B		245.5 kb	Distal	Multiome
RPS27L		277.6 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

102 transcription factors

ARID1B 2 datasets

ChIP K-562 ENCSR822CCM.ARID1B.K-562 297 bp overlap

ChIP K562 ENCFF938UXQ 221 bp overlap

ASXL3 1 dataset

ChIP NCI-H1963_Ab1 GSE145028.ASXL3.NCI-H1963_Ab1 95 bp overlap

Atoh1 4 datasets

Motif DE_12h DE_12h-Atoh1_MA1467.3 7 bp overlap

Motif DE_36h DE_36h-Atoh1_MA1467.3 7 bp overlap

Motif DE_48h DE_48h-Atoh1_MA1467.3 7 bp overlap

Motif DE_60h DE_60h-Atoh1_MA1467.3 7 bp overlap

ChIP NCI-H1963_shASXL3 GSE145028.BAP1.NCI-H1963_shASXL3 151 bp overlap

BRD4 4 datasets

ChIP NCI-H1963_shNONT GSE145028.BRD4.NCI-H1963_shNONT 426 bp overlap

ChIP cortical-interneuron_KCl-pos GSE117508.BRD4.cortical-interneuron_KCl-pos 251 bp overlap

ChIP cortical-interneuron_R133C_KCl-neg_JQ1-neg GSE117508.BRD4.cortical-interneuron_R133C_KCl-neg_JQ1-neg 182 bp overlap

ChIP cortical-interneuron_R133C_KCl-pos_JQ1-neg GSE117508.BRD4.cortical-interneuron_R133C_KCl-pos_JQ1-neg 186 bp overlap

CBFA2T2 2 datasets

ChIP K-562 ENCSR699PVC.CBFA2T2.K-562 306 bp overlap

ChIP K562 ENCFF963TXY 203 bp overlap

CBFA2T3 2 datasets

ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 482 bp overlap

ChIP K562 ENCFF673OEZ 357 bp overlap

CEBPD 1 dataset

ChIP K-562 ENCSR000BVY.CEBPD.K-562 158 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF335XTP 251 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 162 bp overlap

ESR1 2 datasets

ChIP T-47D_Y537S GSE148277.ESR1.T-47D_Y537S 301 bp overlap

ChIP breast_tumor_Male_26 GSE104399.ESR1.breast_tumor_Male_26 169 bp overlap

ESR1_Y537C 1 dataset

ChIP SUM44PE__ESR1_mutant_LTED GSE100074.ESR1_Y537C.SUM44PE__ESR1_mutant_LTED 201 bp overlap

ETV5::FOXO1 3 datasets

Motif DE_12h DE_12h-ETV5FOXO1_MA1947.2 10 bp overlap

Motif DE_36h DE_36h-ETV5FOXO1_MA1947.2 10 bp overlap

Motif DE_48h DE_48h-ETV5FOXO1_MA1947.2 10 bp overlap

FOSL2 1 dataset

Motif DE_36h DE_36h-FOSL2_MA0478.2 10 bp overlap

FOXA1 7 datasets

ChIP 22Rv1 GSE96652.FOXA1.22Rv1 158 bp overlap

ChIP 22Rv1_CST_Crispr_WT3 GSE123618.FOXA1.22Rv1_CST_Crispr_WT3 118 bp overlap

ChIP LNCaP-abl GSE63034.FOXA1.LNCaP-abl 81 bp overlap

ChIP breast-cancer_Veh-2856 GSE128018.FOXA1.breast-cancer_Veh-2856 271 bp overlap

ChIP breast-cancer_Veh-2858 GSE128018.FOXA1.breast-cancer_Veh-2858 127 bp overlap

ChIP breast_tumor_Male_14 GSE104399.FOXA1.breast_tumor_Male_14 130 bp overlap

ChIP primary-breast-cancer_B2_DSG GSE114737.FOXA1.primary-breast-cancer_B2_DSG 290 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 550 bp overlap

ChIP DE DE-FOXA2-1 132 bp overlap

ChIP DE DE-FOXA2-2 506 bp overlap

GATA1 1 dataset

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 315 bp overlap

GATA2 3 datasets

ChIP K-562 ENCSR000BKM.GATA2.K-562 228 bp overlap

ChIP K562 ENCFF088XQT 411 bp overlap

ChIP K562 ENCFF544PCK 251 bp overlap

GATA4 4 datasets

ChIP DE DE-GATA4-1 537 bp overlap

ChIP DE DE-GATA4-1 141 bp overlap

ChIP DE DE-GATA4-2 490 bp overlap

ChIP DE DE-GATA4-2 113 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 447 bp overlap

ChIP DE DE-GATA6-1 149 bp overlap

ChIP DE DE-GATA6-2 467 bp overlap

ChIP DE DE-GATA6-2 96 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 573 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 292 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 796 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 129 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 976 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 685 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 976 bp overlap

GLIS1 1 dataset

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 374 bp overlap

HAND2 4 datasets

Motif DE_12h DE_12h-HAND2_MA1638.2 6 bp overlap

Motif DE_36h DE_36h-HAND2_MA1638.2 6 bp overlap

Motif DE_48h DE_48h-HAND2_MA1638.2 6 bp overlap

Motif DE_60h DE_60h-HAND2_MA1638.2 6 bp overlap

HDAC2 2 datasets

ChIP K-562 ENCSR000BMG.HDAC2.K-562 153 bp overlap

ChIP K-562 ENCSR075HTM.HDAC2.K-562 217 bp overlap

ChIP K-562 ENCSR005NMT.ID3.K-562 420 bp overlap

ChIP K-562 ENCSR005NMT.ID3.K-562 98 bp overlap

IKZF1 2 datasets

ChIP K-562 ENCSR395HWC.IKZF1.K-562 303 bp overlap

ChIP K562 ENCFF771OHZ 497 bp overlap

INSM1 1 dataset

Motif DE_48h DE_48h-INSM1_MA0155.1 12 bp overlap

ChIP K-562 ENCSR854MCV.IRF1.K-562 374 bp overlap

Motif DE_36h DE_36h-Irf1_MA0050.4 11 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 870 bp overlap

ChIP DE_D1 S13-DE-d1-JUN-exp1 582 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 701 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 429 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 875 bp overlap

KDM1A 3 datasets

ChIP K-562 ENCSR360HRA.KDM1A.K-562 220 bp overlap

ChIP K-562 ENCSR908CMW.KDM1A.K-562 210 bp overlap

ChIP K562 ENCFF128TYE 461 bp overlap

KLF1 2 datasets

Motif DE_36h DE_36h-KLF1_MA0493.3 8 bp overlap

Motif DE_48h DE_48h-KLF1_MA0493.3 8 bp overlap

KLF10 2 datasets

Motif DE_36h DE_36h-KLF10_MA1511.2 9 bp overlap

Motif DE_48h DE_48h-KLF10_MA1511.2 9 bp overlap

KLF14 2 datasets

Motif DE_36h DE_36h-KLF14_MA0740.2 9 bp overlap

Motif DE_48h DE_48h-KLF14_MA0740.2 9 bp overlap

KLF2 2 datasets

Motif DE_36h DE_36h-KLF2_MA1515.2 8 bp overlap

Motif DE_48h DE_48h-KLF2_MA1515.2 8 bp overlap

KLF4 2 datasets

Motif DE_36h DE_36h-KLF4_MA0039.5 8 bp overlap

Motif DE_48h DE_48h-KLF4_MA0039.5 8 bp overlap

KLF5 2 datasets

Motif DE_36h DE_36h-KLF5_MA0599.1 10 bp overlap

Motif DE_48h DE_48h-KLF5_MA0599.1 10 bp overlap

KLF9 2 datasets

Motif DE_36h DE_36h-KLF9_MA1107.3 11 bp overlap

Motif DE_48h DE_48h-KLF9_MA1107.3 11 bp overlap

Motif DE_36h DE_36h-Lef1_MA0768.3 8 bp overlap

MAF::NFE2 1 dataset

Motif DE_36h DE_36h-MAFNFE2_MA0501.2 11 bp overlap

ChIP islet ERP004003.MAFB.islet 150 bp overlap

Motif DE_36h DE_36h-MAFK_MA0496.4 10 bp overlap

MED26 1 dataset

ChIP HEK293T GSE121024.MED26.HEK293T 235 bp overlap

MEIS1 4 datasets

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

Motif DE_36h DE_36h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

ChIP 22Rv1_intact GSE117304.MYCN.22Rv1_intact 78 bp overlap

NANOG 3 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 329 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 669 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 370 bp overlap

NCOR1 3 datasets

ChIP K-562 ENCSR910JAI.NCOR1.K-562 233 bp overlap

ChIP K562 ENCFF788MPU 421 bp overlap

ChIP LS180_125 GSE39277.NCOR1.LS180_125 101 bp overlap

NEUROD1 5 datasets

Motif DE_12h DE_12h-NEUROD1_MA1109.2 8 bp overlap

Motif DE_36h DE_36h-NEUROD1_MA1109.2 8 bp overlap

Motif DE_48h DE_48h-NEUROD1_MA1109.2 8 bp overlap

Motif DE_60h DE_60h-NEUROD1_MA1109.2 8 bp overlap

ChIP K-562 ENCSR986CDX.NEUROD1.K-562 188 bp overlap

NEUROG2 4 datasets

Motif DE_12h DE_12h-NEUROG2_MA1642.2 7 bp overlap

Motif DE_36h DE_36h-NEUROG2_MA1642.2 7 bp overlap

Motif DE_48h DE_48h-NEUROG2_MA1642.2 7 bp overlap

Motif DE_60h DE_60h-NEUROG2_MA1642.2 7 bp overlap

NFATC3 1 dataset

Motif DE_36h DE_36h-NFATC3_MA0625.3 6 bp overlap

NFE2 2 datasets

ChIP K-562 ENCSR000FCC.NFE2.K-562 188 bp overlap

ChIP K562 ENCFF163BSI 265 bp overlap

NFIA 4 datasets

Motif DE_12h DE_12h-NFIA_MA0670.2 6 bp overlap

Motif DE_36h DE_36h-NFIA_MA0670.2 6 bp overlap

Motif DE_48h DE_48h-NFIA_MA0670.2 6 bp overlap

ChIP K-562 GSE97661.NFIA.K-562 101 bp overlap

NFIC 2 datasets

ChIP K-562 ENCSR796ITY.NFIC.K-562 302 bp overlap

ChIP K562 ENCFF167YID 361 bp overlap

NFIX 3 datasets

Motif DE_12h DE_12h-NFIX_MA0671.2 6 bp overlap

Motif DE_36h DE_36h-NFIX_MA0671.2 6 bp overlap

Motif DE_48h DE_48h-NFIX_MA0671.2 6 bp overlap

Motif DE_36h DE_36h-NFYB_MA0502.3 9 bp overlap

NR2F2 1 dataset

ChIP K-562 ENCSR000BRS.NR2F2.K-562 165 bp overlap

NR4A1 1 dataset

Motif DE_36h DE_36h-NR4A1_MA1112.3 8 bp overlap

NR4A2 1 dataset

Motif DE_36h DE_36h-NR4A2_MA0160.3 8 bp overlap

Neurod2 4 datasets

Motif DE_12h DE_12h-Neurod2_MA0668.3 8 bp overlap

Motif DE_36h DE_36h-Neurod2_MA0668.3 8 bp overlap

Motif DE_48h DE_48h-Neurod2_MA0668.3 8 bp overlap

Motif DE_60h DE_60h-Neurod2_MA0668.3 8 bp overlap

Nfatc1 1 dataset

Motif DE_36h DE_36h-Nfatc1_MA0624.3 6 bp overlap

Nfe2l2 1 dataset

Motif DE_36h DE_36h-Nfe2l2_MA0150.3 11 bp overlap

ChIP breast_tumor_Male_26 GSE104399.PGR.breast_tumor_Male_26 150 bp overlap

POU2F1 1 dataset

ChIP 22Rv1_Veh GSE123565.POU2F1.22Rv1_Veh 67 bp overlap

POU5F1 2 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 496 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 239 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 369 bp overlap

Plagl1 3 datasets

Motif DE_12h DE_12h-Plagl1_MA1615.2 8 bp overlap

Motif DE_36h DE_36h-Plagl1_MA1615.2 8 bp overlap

Motif DE_48h DE_48h-Plagl1_MA1615.2 8 bp overlap

Prdm15 2 datasets

Motif DE_36h DE_36h-Prdm15_MA1616.2 11 bp overlap

Motif DE_60h DE_60h-Prdm15_MA1616.2 11 bp overlap

Motif DE_36h DE_36h-RXRB_MA0855.1 14 bp overlap

SMAD2 2 datasets

ChIP endoderm GSE29422.SMAD2.endoderm 312 bp overlap

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 463 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 966 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 976 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 905 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 976 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 916 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 976 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 587 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 214 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 263 bp overlap

SMARCA4 1 dataset

ChIP A-549_AG15688 GSE132290.SMARCA4.A-549_AG15688 205 bp overlap

SMARCC1 2 datasets

ChIP DE_D1 S10-DE-d1-BAF155-exp1 502 bp overlap

ChIP DE_D1 S15-DE-d1-BAF155-exp1 522 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 379 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 928 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 263 bp overlap

Motif DE_48h DE_48h-SP1_MA0079.5 9 bp overlap

Motif DE_48h DE_48h-SP4_MA0685.2 9 bp overlap

Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap

TAL1 8 datasets

ChIP K-562 ENCSR000EHB.TAL1.K-562 220 bp overlap

ChIP K-562 GSE107726.TAL1.K-562 239 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.TAL1.K-562_dCas9-LSD1 270 bp overlap

ChIP K-562_enCRISPRi-KL GSE132212.TAL1.K-562_enCRISPRi-KL 257 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.TAL1.K-562_enCRISPRi-LK 222 bp overlap

ChIP K-562_sgGal4 GSE132212.TAL1.K-562_sgGal4 180 bp overlap

ChIP K562 ENCFF620GMX 379 bp overlap

ChIP K562 ENCFF661CCK 277 bp overlap

TCF12 2 datasets

ChIP K-562 ENCSR744WOO.TCF12.K-562 349 bp overlap

ChIP K562 ENCFF931DJY 391 bp overlap

TCF3 2 datasets

ChIP K-562 ENCSR970OJY.TCF3.K-562 294 bp overlap

ChIP K562 ENCFF319QZT 381 bp overlap

TEAD4 1 dataset

ChIP K562 ENCFF673NIK 365 bp overlap

TFAP2A 1 dataset

Motif DE_48h DE_48h-TFAP2A_MA0810.2 11 bp overlap

Motif DE_36h DE_36h-THRB_MA1576.2 18 bp overlap

TWIST1 4 datasets

Motif DE_12h DE_12h-TWIST1_MA1123.3 8 bp overlap

Motif DE_36h DE_36h-TWIST1_MA1123.3 8 bp overlap

Motif DE_48h DE_48h-TWIST1_MA1123.3 8 bp overlap

Motif DE_60h DE_60h-TWIST1_MA1123.3 8 bp overlap

ChIP HEK293 ENCFF906HIR 290 bp overlap

ChIP HEK293 ENCSR966PJJ.WT1.HEK293 238 bp overlap

Motif DE_48h DE_48h-Wt1_MA1627.2 10 bp overlap

ChIP Hep-G2_NC GSE120104.YY1.Hep-G2_NC 261 bp overlap

ChIP Hep-G2_RBM25-KD GSE120104.YY1.Hep-G2_RBM25-KD 248 bp overlap

ChIP K-562 ENCSR000BMH.YY1.K-562 200 bp overlap

ChIP K562 ENCFF660QRE 291 bp overlap

ZKSCAN5 1 dataset

Motif DE_48h DE_48h-ZKSCAN5_MA1652.2 9 bp overlap

ZNF140 3 datasets

Motif DE_12h DE_12h-ZNF140_MA1589.2 19 bp overlap

Motif DE_36h DE_36h-ZNF140_MA1589.2 19 bp overlap

Motif DE_48h DE_48h-ZNF140_MA1589.2 19 bp overlap

ZNF148 2 datasets

Motif DE_48h DE_48h-ZNF148_MA1653.2 10 bp overlap

ChIP K-562 ENCSR018MSO.ZNF148.K-562 247 bp overlap

ZNF16 4 datasets

Motif DE_12h DE_12h-ZNF16_MA1654.2 21 bp overlap

Motif DE_36h DE_36h-ZNF16_MA1654.2 21 bp overlap

Motif DE_48h DE_48h-ZNF16_MA1654.2 21 bp overlap

Motif DE_60h DE_60h-ZNF16_MA1654.2 21 bp overlap

ZNF257 1 dataset

Motif DE_48h DE_48h-ZNF257_MA1710.2 10 bp overlap

ZNF263 1 dataset

Motif DE_48h DE_48h-ZNF263_MA0528.3 7 bp overlap

ZNF281 2 datasets

Motif DE_48h DE_48h-ZNF281_MA1630.3 10 bp overlap

ChIP K562 ENCFF594VNM 389 bp overlap

ZNF316 1 dataset

ChIP K-562 ENCSR200JYP.ZNF316.K-562 242 bp overlap

ZNF395 1 dataset

ChIP K562 ENCFF464EIT 672 bp overlap

ZNF449 2 datasets

ChIP HEK293 ENCFF764ZIC 65 bp overlap

ChIP HEK293 ENCSR738SLS.ZNF449.HEK293 183 bp overlap

ZNF707 3 datasets

Motif DE_12h DE_12h-ZNF707_MA1715.1 15 bp overlap

Motif DE_36h DE_36h-ZNF707_MA1715.1 15 bp overlap

Motif DE_48h DE_48h-ZNF707_MA1715.1 15 bp overlap

Znf423 1 dataset

Motif DE_36h DE_36h-Znf423_MA0116.1 15 bp overlap