Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF395. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF395 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF395, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:28,092,624–28,093,537 | 293.1 kb | Distal (>10kb) Multiome | 907 | |
| chr8:28,318,563–28,319,487 | 67.1 kb | Distal (>10kb) Multiome | 205 | |
| chr8:28,384,745–28,386,965 | 272 bp | At TSS Multiome | 674 | |
| chr8:28,401,081–28,402,986 | 16.0 kb | Distal (>10kb) Multiome | 941 | |
| chr8:28,411,636–28,412,462 | 25.9 kb | Distal (>10kb) Multiome | 805 | |
| chr8:28,429,151–28,429,912 | 43.4 kb | Distal (>10kb) Multiome | 77 | |
| chr8:28,490,087–28,490,872 | 104.3 kb | Distal (>10kb) Multiome | 535 | |
| chr8:28,493,649–28,495,132 | 108.1 kb | Distal (>10kb) Multiome | 656 | |
| chr8:28,622,031–28,623,620 | 236.4 kb | Distal (>10kb) Multiome | 828 | |
| chr8:28,700,738–28,702,456 | 315.4 kb | Distal (>10kb) Multiome | 728 |
Genomic view of the ZNF395 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.