RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).[supplied by OMIM, Nov 2010]
Transcription factors with Perturb-seq knockdown data for RAB8B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB8B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB8B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:63,041,931–63,043,171 | 147.1 kb | Distal (>10kb) Multiome | 510 | |
| chr15:63,047,449–63,049,284 | 141.2 kb | Distal (>10kb) Multiome | 977 | |
| chr15:63,052,986–63,053,551 | 136.2 kb | Distal (>10kb) Multiome | 265 | |
| chr15:63,121,504–63,122,682 | 67.7 kb | Distal (>10kb) Multiome | 750 | |
| chr15:63,157,102–63,158,166 | 32.1 kb | Distal (>10kb) Multiome | 954 | |
| chr15:63,188,797–63,190,016 | 142 bp | At TSS Multiome | 573 | |
| chr15:63,277,063–63,278,175 | 87.8 kb | Distal (>10kb) Multiome | 651 | |
| chr15:63,381,566–63,382,221 | 192.3 kb | Distal (>10kb) Multiome | 358 | |
| chr15:63,396,367–63,396,999 | 207.1 kb | Distal (>10kb) Multiome | 284 | |
| chr15:63,434,760–63,435,736 | 245.5 kb | Distal (>10kb) Multiome | 102 | |
| chr15:63,466,399–63,467,254 | 277.2 kb | Distal (>10kb) Multiome | 497 |
Genomic view of the RAB8B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.