This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for APH1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APH1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APH1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:63,041,931–63,043,171 | 235.1 kb | Distal (>10kb) Multiome | 510 | |
| chr15:63,047,449–63,049,284 | 229.2 kb | Distal (>10kb) Multiome | 977 | |
| chr15:63,052,986–63,053,551 | 224.2 kb | Distal (>10kb) Multiome | 265 | |
| chr15:63,121,504–63,122,682 | 155.7 kb | Distal (>10kb) Multiome | 750 | |
| chr15:63,157,102–63,158,166 | 120.1 kb | Distal (>10kb) Multiome HiCAR | 954 | |
| chr15:63,188,797–63,190,016 | 88.2 kb | Distal (>10kb) Multiome | 573 | |
| chr15:63,277,063–63,278,175 | 202 bp | At TSS Multiome | 651 | |
| chr15:63,381,566–63,382,221 | 104.3 kb | Distal (>10kb) Multiome | 358 | |
| chr15:63,396,367–63,396,999 | 119.1 kb | Distal (>10kb) Multiome | 284 | |
| chr15:63,434,760–63,435,736 | 157.4 kb | Distal (>10kb) Multiome | 102 | |
| chr15:63,466,399–63,467,254 | 189.2 kb | Distal (>10kb) Multiome HiCAR | 497 | |
| chr15:63,502,962–63,505,773 | 225.7 kb | Distal (>10kb) Multiome | 1114 |
Genomic view of the APH1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.