chr12 : 104,292,165 – 104,292,420

255 bp 126 TFs 1 linked gene

This 255 bp open chromatin element is linked to TXNRD1 and is bound by 126 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
TXNRD1		5.2 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

126 transcription factors

ALX3 1 dataset

Motif DE_12h DE_12h-ALX3_MA0634.2 6 bp overlap

ARGFX 1 dataset

Motif DE_12h DE_12h-ARGFX_MA1463.2 8 bp overlap

ARID2 3 datasets

ChIP Aska-SS GSE108025.ARID2.Aska-SS 145 bp overlap

ChIP Aska-SS_shSSX GSE108025.ARID2.Aska-SS_shSSX 230 bp overlap

ChIP BIN-67_lentivirus-SMARCA4 GSE117734.ARID2.BIN-67_lentivirus-SMARCA4 255 bp overlap

ASCL1 1 dataset

Motif DE_12h DE_12h-ASCL1_MA1631.2 9 bp overlap

ATF2 1 dataset

ChIP WA01 ENCSR000BQU.ATF2.WA01 212 bp overlap

ATF3 1 dataset

ChIP A-549 ENCSR000BPS.ATF3.A-549 148 bp overlap

ATOH8 1 dataset

ChIP A549 ENCFF772HNB 120 bp overlap

Alx1 1 dataset

Motif DE_12h DE_12h-Alx1_MA0854.2 8 bp overlap

Alx4 1 dataset

Motif DE_12h DE_12h-Alx4_MA0853.2 12 bp overlap

Arx 1 dataset

Motif DE_12h DE_12h-Arx_MA0874.2 10 bp overlap

Ascl2 1 dataset

Motif DE_12h DE_12h-Ascl2_MA0816.1 10 bp overlap

BCL3 1 dataset

ChIP A-549 ENCSR000BQH.BCL3.A-549 169 bp overlap

BCOR 1 dataset

ChIP WA01 GSE104690.BCOR.WA01 157 bp overlap

BRD4 7 datasets

ChIP HeLa_JQ1 GSE151038.BRD4.HeLa_JQ1 120 bp overlap

ChIP SUM159PT_100nMtrametinib300nMJQ1_24h GSE87418.BRD4.SUM159PT_100nMtrametinib300nMJQ1_24h 183 bp overlap

ChIP SUM159PT_100nMtrametinib_24h GSE87418.BRD4.SUM159PT_100nMtrametinib_24h 191 bp overlap

ChIP SUM159PT_300nMJQ1_24h GSE87418.BRD4.SUM159PT_300nMJQ1_24h 126 bp overlap

ChIP SUM159PT_shMYC_DMSO_48h GSE87418.BRD4.SUM159PT_shMYC_DMSO_48h 145 bp overlap

ChIP SUM159PT_shMYC_dox_48h GSE87418.BRD4.SUM159PT_shMYC_dox_48h 255 bp overlap

ChIP SUM229PE_neg_30nMtrametinib_24h GSE87418.BRD4.SUM229PE_neg_30nMtrametinib_24h 172 bp overlap

CHD1 1 dataset

ChIP A-549 ENCSR398YBM.CHD1.A-549 235 bp overlap

CHD7 1 dataset

ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 203 bp overlap

DRGX 1 dataset

Motif DE_12h DE_12h-DRGX_MA1481.2 6 bp overlap

EHF 1 dataset

ChIP A549 ENCFF352AOI 134 bp overlap

ELF1 1 dataset

ChIP A-549 ENCSR000BPT.ELF1.A-549 106 bp overlap

EMX1 1 dataset

Motif DE_12h DE_12h-EMX1_MA0612.3 6 bp overlap

EMX2 1 dataset

Motif DE_12h DE_12h-EMX2_MA0886.2 6 bp overlap

EN1 1 dataset

Motif DE_12h DE_12h-EN1_MA0027.3 6 bp overlap

EP300 1 dataset

ChIP A-549 ENCSR000BPW.EP300.A-549 127 bp overlap

ESX1 1 dataset

Motif DE_12h DE_12h-ESX1_MA0644.3 7 bp overlap

ETS1 1 dataset

ChIP DU145 GSE59021.ETS1.DU145 105 bp overlap

EVX1 1 dataset

Motif DE_12h DE_12h-EVX1_MA0887.2 6 bp overlap

EVX2 1 dataset

Motif DE_12h DE_12h-EVX2_MA0888.2 6 bp overlap

Ebf4 1 dataset

Motif DE_12h DE_12h-Ebf4_MA2122.1 11 bp overlap

FIGLA 1 dataset

Motif DE_12h DE_12h-FIGLA_MA0820.2 6 bp overlap

FOSB 2 datasets

ChIP A-549 ENCSR918GHT.FOSB.A-549 158 bp overlap

ChIP A549 ENCFF029EEU 125 bp overlap

FOSL2 1 dataset

ChIP A-549 ENCSR448TVS.FOSL2.A-549 73 bp overlap

FOXA1 2 datasets

ChIP A-549 ENCSR000BPX.FOXA1.A-549 73 bp overlap

ChIP A-549 ENCSR000BRD.FOXA1.A-549 75 bp overlap

FOXF2 1 dataset

ChIP A549 ENCFF148XDC 148 bp overlap

FOXS1 1 dataset

ChIP A549 ENCFF870VDS 111 bp overlap

GATA6 2 datasets

ChIP DE_D1 S09-DE-d1-GATA6-exp1 255 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 255 bp overlap

GSX1 1 dataset

Motif DE_12h DE_12h-GSX1_MA0892.2 6 bp overlap

HIC2 1 dataset

Motif DE_12h DE_12h-HIC2_MA0738.2 6 bp overlap

HMGA2 1 dataset

ChIP A549 ENCFF624CAQ 93 bp overlap

HMGXB4 1 dataset

ChIP A549 ENCFF261MIW 171 bp overlap

HOXA1 1 dataset

Motif DE_12h DE_12h-HOXA1_MA1495.2 6 bp overlap

HOXA2 1 dataset

Motif DE_12h DE_12h-HOXA2_MA0900.3 6 bp overlap

HOXA7 2 datasets

ChIP A-549 ENCSR402OYZ.HOXA7.A-549 140 bp overlap

ChIP A549 ENCFF746ZBJ 125 bp overlap

HOXB2 1 dataset

Motif DE_12h DE_12h-HOXB2_MA0902.3 6 bp overlap

HOXB3 1 dataset

Motif DE_12h DE_12h-HOXB3_MA0903.2 6 bp overlap

HOXB5 2 datasets

ChIP A549 ENCFF891VDO 148 bp overlap

Motif DE_12h DE_12h-HOXB5_MA0904.3 6 bp overlap

HOXC13 1 dataset

Motif DE_12h DE_12h-HOXC13_MA0907.2 9 bp overlap

HOXC8 1 dataset

Motif DE_12h DE_12h-HOXC8_MA1505.2 6 bp overlap

HOXD12 1 dataset

Motif DE_12h DE_12h-HOXD12_MA0873.2 10 bp overlap

IKZF3 1 dataset

ChIP HEK293 ENCSR304AMN.IKZF3.HEK293 93 bp overlap

ISX 1 dataset

Motif DE_12h DE_12h-ISX_MA0654.2 6 bp overlap

JUN 3 datasets

ChIP A549 ENCFF191QZG 255 bp overlap

ChIP A549 ENCFF846DUV 176 bp overlap

ChIP A549 ENCFF846DUV 109 bp overlap

JUND 2 datasets

ChIP A-549 ENCSR000BRF.JUND.A-549 161 bp overlap

ChIP HT29_DSMO GSE77039.JUND.HT29_DSMO 236 bp overlap

KLF9 1 dataset

ChIP GBM1A GSE62211.KLF9.GBM1A 90 bp overlap

LMX1A 1 dataset

Motif DE_12h DE_12h-LMX1A_MA0702.3 7 bp overlap

LMX1B 1 dataset

Motif DE_12h DE_12h-LMX1B_MA0703.3 8 bp overlap

Lhx4 1 dataset

Motif DE_12h DE_12h-Lhx4_MA0704.2 6 bp overlap

Lhx8 1 dataset

Motif DE_12h DE_12h-Lhx8_MA0705.2 6 bp overlap

MAX 2 datasets

ChIP NCI-H2171 GSE36354.MAX.NCI-H2171 161 bp overlap

ChIP NCI-H2171 GSE41105.MAX.NCI-H2171 183 bp overlap

MED1 3 datasets

ChIP SUM159PT_100nMtrametinib300nMJQ1_24h GSE87418.MED1.SUM159PT_100nMtrametinib300nMJQ1_24h 154 bp overlap

ChIP SUM159PT_100nMtrametinib_24h GSE87418.MED1.SUM159PT_100nMtrametinib_24h 185 bp overlap

ChIP SUM159PT_300nMJQ1_24h GSE87418.MED1.SUM159PT_300nMJQ1_24h 217 bp overlap

MIXL1 1 dataset

Motif DE_12h DE_12h-MIXL1_MA0662.2 6 bp overlap

MNX1 1 dataset

Motif DE_12h DE_12h-MNX1_MA0707.3 6 bp overlap

MSC 1 dataset

Motif DE_12h DE_12h-MSC_MA0665.1 10 bp overlap

MYCN 2 datasets

ChIP SHEP-21N GSE80151.MYCN.SHEP-21N 189 bp overlap

ChIP SHEP-21N_DOX_0H GSE80151.MYCN.SHEP-21N_DOX_0H 189 bp overlap

MZF1 1 dataset

Motif DE_12h DE_12h-MZF1_MA0056.3 8 bp overlap

NANOG 4 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 255 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 186 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 255 bp overlap

ChIP hESC GSE18292.NANOG.hESC 92 bp overlap

NCAPH2 2 datasets

ChIP IMR-90_FLAG_G GSE118494.NCAPH2.IMR-90_FLAG_G 171 bp overlap

ChIP IMR-90_FLAG_OIS GSE118494.NCAPH2.IMR-90_FLAG_OIS 246 bp overlap

NIPBL 1 dataset

ChIP A-549 GSE76893.NIPBL.A-549 255 bp overlap

NKX2-1 1 dataset

ChIP H9_derived-cIN GSE99937.NKX2-1.H9_derived-cIN 164 bp overlap

NKX6-1 1 dataset

Motif DE_12h DE_12h-NKX6-1_MA0674.2 7 bp overlap

NKX6-2 1 dataset

Motif DE_12h DE_12h-NKX6-2_MA0675.2 6 bp overlap

NOTO 1 dataset

Motif DE_12h DE_12h-NOTO_MA0710.2 7 bp overlap

ONECUT2 1 dataset

ChIP A-549 GSE102599.ONECUT2.A-549 182 bp overlap

PAF1 1 dataset

ChIP HCT-116_ab20662 GSE97527.PAF1.HCT-116_ab20662 150 bp overlap

PDX1 1 dataset

Motif DE_12h DE_12h-PDX1_MA0132.3 6 bp overlap

PML 1 dataset

ChIP K-562 ENCSR000BQY.PML.K-562 133 bp overlap

POLR2A 8 datasets

ChIP A549 ENCFF034EBG 220 bp overlap

ChIP A549 ENCFF034EBG 163 bp overlap

ChIP HCT116 ENCFF508RDJ 255 bp overlap

ChIP HCT116 ENCFF508RDJ 108 bp overlap

ChIP HeLa-S3 ENCFF773DNG 177 bp overlap

ChIP HepG2 ENCFF350RIU 255 bp overlap

ChIP HepG2 ENCFF350RIU 108 bp overlap

ChIP Panc1 ENCFF290KAB 143 bp overlap

POLR2G 1 dataset

ChIP HepG2 ENCFF508UTS 255 bp overlap

POU4F1 1 dataset

Motif DE_12h DE_12h-POU4F1_MA0790.2 12 bp overlap

POU4F2 1 dataset

Motif DE_12h DE_12h-POU4F2_MA0683.2 15 bp overlap

POU4F3 1 dataset

Motif DE_12h DE_12h-POU4F3_MA0791.2 12 bp overlap

POU5F1 4 datasets

ChIP HUES-8 GSE109524.POU5F1.HUES-8 255 bp overlap

ChIP NCCIT_SNF5 GSE36134.POU5F1.NCCIT_SNF5 192 bp overlap

ChIP hESC ENCSR264RJX.POU5F1.hESC 117 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 233 bp overlap

POU6F1 1 dataset

Motif DE_12h DE_12h-POU6F1_MA0628.2 6 bp overlap

PRDM1 1 dataset

ChIP HEK293 ENCFF302TBP 114 bp overlap

PRRX1 1 dataset

Motif DE_12h DE_12h-PRRX1_MA0716.2 6 bp overlap

RARB 1 dataset

ChIP A549 ENCFF837HCQ 60 bp overlap

RAX2 1 dataset

Motif DE_12h DE_12h-RAX2_MA0717.2 6 bp overlap

RBFOX2 2 datasets

ChIP K-562 ENCSR822LBD.RBFOX2.K-562 240 bp overlap

ChIP K-562 GSE120104.RBFOX2.K-562 240 bp overlap

RELA 2 datasets

ChIP aortic-endothelial-cell_IL1B_D10 GSE139377.RELA.aortic-endothelial-cell_IL1B_D10 74 bp overlap

ChIP aortic-endothelial-cell_IL1B_D8 GSE139377.RELA.aortic-endothelial-cell_IL1B_D8 190 bp overlap

REST 3 datasets

ChIP A-549 ENCSR892DRK.REST.A-549 184 bp overlap

ChIP A-549 ENCSR000BQP.REST.A-549 249 bp overlap

ChIP A549 ENCFF148AIS 220 bp overlap

RPA2_phospho 3 datasets

ChIP HeLa GSE108172.RPA2_phospho.HeLa 255 bp overlap

ChIP HeLa_shASF GSE108172.RPA2_phospho.HeLa_shASF 199 bp overlap

ChIP HeLa_shTOP1 GSE108172.RPA2_phospho.HeLa_shTOP1 227 bp overlap

SHOX 1 dataset

Motif DE_12h DE_12h-SHOX_MA0630.2 6 bp overlap

SIN3A 2 datasets

ChIP A-549 ENCSR000BRM.SIN3A.A-549 182 bp overlap

ChIP A-549 ENCSR513XQX.SIN3A.A-549 217 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 227 bp overlap

SMAD2_3 2 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 225 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 134 bp overlap

SMAD3 3 datasets

ChIP NCI-H441 GSE51509.SMAD3.NCI-H441 145 bp overlap

ChIP NCI-H441_SIITTF1 GSE51509.SMAD3.NCI-H441_SIITTF1 72 bp overlap

ChIP SUM159PT GSE130364.SMAD3.SUM159PT 78 bp overlap

SMAD5 1 dataset

ChIP K-562 ENCSR000FCD.SMAD5.K-562 174 bp overlap

SMARCA4 1 dataset

ChIP BIN-67_lentivirus-SMARCA4-T910M GSE117734.SMARCA4.BIN-67_lentivirus-SMARCA4-T910M 255 bp overlap

SMARCC1 1 dataset

ChIP BIN-67_lentivirus-SMARCA4-T910M GSE117734.SMARCC1.BIN-67_lentivirus-SMARCA4-T910M 135 bp overlap

SNAI1 1 dataset

Motif DE_12h DE_12h-SNAI1_MA1558.2 7 bp overlap

SP1 2 datasets

ChIP A-549 ENCSR000BPE.SP1.A-549 219 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 145 bp overlap

SPDEF 1 dataset

ChIP A-549 GSE86957.SPDEF.A-549 231 bp overlap

SSRP1 1 dataset

ChIP HT-1080_AclacinomycinA GSE107595.SSRP1.HT-1080_AclacinomycinA 201 bp overlap

STAT1_pS727 1 dataset

ChIP SET-2 GSE100566.STAT1_pS727.SET-2 205 bp overlap

SUPT5H 1 dataset

ChIP HCT-116_pThr806 GSE138548.SUPT5H.HCT-116_pThr806 230 bp overlap

Shox2 1 dataset

Motif DE_12h DE_12h-Shox2_MA0720.2 6 bp overlap

TCF12 2 datasets

ChIP A-549 ENCSR000BQQ.TCF12.A-549 239 bp overlap

Motif DE_12h DE_12h-TCF12_MA1648.2 7 bp overlap

TCF3 1 dataset

Motif DE_12h DE_12h-TCF3_MA0522.4 7 bp overlap

TCF4 1 dataset

Motif DE_12h DE_12h-TCF4_MA0830.3 8 bp overlap

TCF7L2 1 dataset

ChIP PANC-1 ENCSR000EXL.TCF7L2.PANC-1 255 bp overlap

TLX2 1 dataset

Motif DE_12h DE_12h-TLX2_MA1577.2 6 bp overlap

TP53 1 dataset

ChIP A549 ENCFF229ULU 58 bp overlap

TP63 1 dataset

ChIP A549 ENCFF399JYQ 82 bp overlap

UNCX 1 dataset

Motif DE_12h DE_12h-UNCX_MA0721.2 6 bp overlap

VAX1 1 dataset

Motif DE_12h DE_12h-VAX1_MA0722.2 7 bp overlap

VAX2 1 dataset

Motif DE_12h DE_12h-VAX2_MA0723.3 6 bp overlap

VSX1 1 dataset

Motif DE_12h DE_12h-VSX1_MA0725.2 7 bp overlap

VSX2 1 dataset

Motif DE_12h DE_12h-VSX2_MA0726.2 7 bp overlap

YY1 3 datasets

ChIP H1 ENCFF524BTL 189 bp overlap

ChIP Huh-7 GSE97411.YY1.Huh-7 255 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 156 bp overlap

ZEB1 1 dataset

Motif DE_12h DE_12h-ZEB1_MA0103.4 6 bp overlap

ZIC1 1 dataset

Motif DE_12h DE_12h-ZIC1_MA0696.1 14 bp overlap

ZIC5 1 dataset

Motif DE_12h DE_12h-ZIC5_MA1584.2 15 bp overlap

ZMYND11 1 dataset

ChIP HeLa GSE51672.ZMYND11.HeLa 114 bp overlap

ZNF302 1 dataset

ChIP A549 ENCFF333REI 127 bp overlap

ZNF362 1 dataset

ChIP HEK293 ENCSR715QNO.ZNF362.HEK293 128 bp overlap

ZNF366 3 datasets

ChIP HEK293 ENCFF799ATK 200 bp overlap

ChIP HEK293 ENCFF799ATK 255 bp overlap

ChIP HEK293 ENCSR106EBH.ZNF366.HEK293 118 bp overlap

mix-a 1 dataset

Motif DE_12h DE_12h-mix-a_MA0621.2 7 bp overlap