Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF362. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF362 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF362, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:32,963,782–32,965,243 | 291.6 kb | Distal (>10kb) Multiome | 882 | |
| chr1:32,972,824–32,973,439 | 283.5 kb | Distal (>10kb) Multiome | 489 | |
| chr1:33,036,391–33,037,199 | 219.6 kb | Distal (>10kb) Multiome | 948 | |
| chr1:33,080,764–33,081,783 | 175.4 kb | Distal (>10kb) Multiome | 556 | |
| chr1:33,127,180–33,127,648 | 129.2 kb | Distal (>10kb) Multiome | 877 | |
| chr1:33,152,752–33,153,392 | 103.4 kb | Distal (>10kb) Multiome | 151 | |
| chr1:33,180,551–33,182,306 | 75.6 kb | Distal (>10kb) Multiome | 692 | |
| chr1:33,255,428–33,256,795 | 857 bp | At TSS Multiome | 509 | |
| chr1:33,338,430–33,338,960 | 82.1 kb | Distal (>10kb) Multiome | 254 | |
| chr1:33,342,108–33,342,803 | 85.9 kb | Distal (>10kb) Multiome | 722 | |
| chr1:33,349,195–33,350,690 | 93.4 kb | Distal (>10kb) Multiome | 874 | |
| chr1:33,363,845–33,364,278 | 107.5 kb | Distal (>10kb) Multiome | 214 | |
| chr1:33,430,392–33,431,511 | 174.5 kb | Distal (>10kb) Multiome | 555 | |
| chr1:33,472,141–33,472,925 | 216.0 kb | Distal (>10kb) Multiome | 656 |
Genomic view of the ZNF362 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.