chr1 : 208,564,276 – 208,564,841

565 bp 126 TFs 1 linked gene

This 565 bp open chromatin element is linked to PLXNA2 and is bound by 126 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
PLXNA2		320.3 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

126 transcription factors

AR 1 dataset

ChIP breast_tumor_Male_26 GSE104399.AR.breast_tumor_Male_26 228 bp overlap

ATF2 1 dataset

Motif DE_48h DE_48h-ATF2_MA1632.2 10 bp overlap

ATF3 1 dataset

Motif DE_48h DE_48h-ATF3_MA0605.3 10 bp overlap

ATF7 1 dataset

Motif DE_48h DE_48h-ATF7_MA0834.2 10 bp overlap

Ascl2 2 datasets

Motif DE_48h DE_48h-Ascl2_MA0816.1 10 bp overlap

Motif DE_72h DE_72h-Ascl2_MA0816.1 10 bp overlap

Atf3 2 datasets

Motif DE_48h DE_48h-Atf3_MA1988.2 7 bp overlap

Motif DE_72h DE_72h-Atf3_MA1988.2 7 bp overlap

BARX1 1 dataset

Motif DE_48h DE_48h-BARX1_MA0875.2 6 bp overlap

BATF 2 datasets

Motif DE_48h DE_48h-BATF_MA1634.2 7 bp overlap

Motif DE_72h DE_72h-BATF_MA1634.2 7 bp overlap

BATF3 2 datasets

Motif DE_48h DE_48h-BATF3_MA0835.3 7 bp overlap

Motif DE_72h DE_72h-BATF3_MA0835.3 7 bp overlap

BATF::JUN 2 datasets

Motif DE_48h DE_48h-BATFJUN_MA0462.3 7 bp overlap

Motif DE_72h DE_72h-BATFJUN_MA0462.3 7 bp overlap

BNC2 2 datasets

Motif DE_48h DE_48h-BNC2_MA1928.2 7 bp overlap

Motif DE_72h DE_72h-BNC2_MA1928.2 7 bp overlap

BSX 1 dataset

Motif DE_48h DE_48h-BSX_MA0876.2 6 bp overlap

CDK6 1 dataset

ChIP KB_IL GSE52469.CDK6.KB_IL 111 bp overlap

CEBPA 1 dataset

Motif DE_48h DE_48h-CEBPA_MA0102.5 10 bp overlap

CREB1 1 dataset

Motif DE_48h DE_48h-CREB1_MA0018.5 8 bp overlap

CREM 1 dataset

Motif DE_48h DE_48h-CREM_MA0609.3 10 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF460KDD 251 bp overlap

Creb5 1 dataset

Motif DE_48h DE_48h-Creb5_MA0840.2 10 bp overlap

DLX1 1 dataset

Motif DE_48h DE_48h-DLX1_MA0879.3 6 bp overlap

DLX6 1 dataset

Motif DE_48h DE_48h-DLX6_MA0882.2 6 bp overlap

Ddit3::Cebpa 1 dataset

Motif DE_48h DE_48h-Ddit3Cebpa_MA0019.2 10 bp overlap

Dlx2 1 dataset

Motif DE_48h DE_48h-Dlx2_MA0885.3 8 bp overlap

Dlx3 1 dataset

Motif DE_48h DE_48h-Dlx3_MA0880.2 6 bp overlap

Dlx4 1 dataset

Motif DE_48h DE_48h-Dlx4_MA0881.2 6 bp overlap

Dlx5 1 dataset

Motif DE_48h DE_48h-Dlx5_MA1476.3 8 bp overlap

EOMES 2 datasets

Motif DE_48h DE_48h-EOMES_MA0800.2 9 bp overlap

ChIP hESC GSE26097.EOMES.hESC 410 bp overlap

ESR1 2 datasets

ChIP breast_tumor_Male_10 GSE104399.ESR1.breast_tumor_Male_10 73 bp overlap

ChIP breast_tumor_Male_26 GSE104399.ESR1.breast_tumor_Male_26 315 bp overlap

EZH2 1 dataset

ChIP THP-1 GSE135024.EZH2.THP-1 418 bp overlap

FOS 1 dataset

Motif DE_48h DE_48h-FOS_MA1951.2 13 bp overlap

FOS::JUN 1 dataset

Motif DE_48h DE_48h-FOSJUN_MA1126.2 10 bp overlap

FOSB::JUN 1 dataset

Motif DE_48h DE_48h-FOSBJUN_MA1127.1 11 bp overlap

FOSB::JUNB 1 dataset

Motif DE_48h DE_48h-FOSBJUNB_MA1136.1 10 bp overlap

FOSL1 2 datasets

Motif DE_48h DE_48h-FOSL1_MA0477.3 9 bp overlap

Motif DE_72h DE_72h-FOSL1_MA0477.3 9 bp overlap

FOSL1::JUND 1 dataset

Motif DE_48h DE_48h-FOSL1JUND_MA1143.2 9 bp overlap

FOSL2::JUN 1 dataset

Motif DE_48h DE_48h-FOSL2JUN_MA1131.2 10 bp overlap

FOSL2::JUNB 1 dataset

Motif DE_48h DE_48h-FOSL2JUNB_MA1139.2 10 bp overlap

FOSL2::JUND 1 dataset

Motif DE_48h DE_48h-FOSL2JUND_MA1145.2 10 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 565 bp overlap

ChIP DE DE-FOXA2-2 565 bp overlap

GATA2 1 dataset

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

GATA4 4 datasets

ChIP DE DE-GATA4-1 565 bp overlap

ChIP DE DE-GATA4-2 565 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 343 bp overlap

GATA6 12 datasets

ChIP DE DE-GATA6-1 565 bp overlap

ChIP DE DE-GATA6-2 565 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 378 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 382 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 308 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 449 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 421 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 399 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 469 bp overlap

ChIP foregut GSE117136.GATA6.foregut 316 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 350 bp overlap

GBX2 1 dataset

Motif DE_48h DE_48h-GBX2_MA0890.2 6 bp overlap

Gata3 1 dataset

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

HESX1 1 dataset

Motif DE_48h DE_48h-HESX1_MA0894.2 6 bp overlap

HOXA6 1 dataset

Motif DE_48h DE_48h-HOXA6_MA1497.2 7 bp overlap

HOXA7 1 dataset

Motif DE_48h DE_48h-HOXA7_MA1498.3 6 bp overlap

HOXB6 1 dataset

Motif DE_48h DE_48h-HOXB6_MA1500.2 7 bp overlap

HOXB7 1 dataset

Motif DE_48h DE_48h-HOXB7_MA1501.2 7 bp overlap

HOXB8 1 dataset

Motif DE_48h DE_48h-HOXB8_MA1502.2 7 bp overlap

HOXD8 1 dataset

Motif DE_48h DE_48h-HOXD8_MA0910.3 7 bp overlap

Hmx1 1 dataset

Motif DE_48h DE_48h-Hmx1_MA0896.2 9 bp overlap

IKZF1 2 datasets

Motif DE_48h DE_48h-IKZF1_MA1508.2 8 bp overlap

Motif DE_72h DE_72h-IKZF1_MA1508.2 8 bp overlap

JDP2 1 dataset

Motif DE_48h DE_48h-JDP2_MA0656.2 10 bp overlap

JUN 3 datasets

ChIP DE_D1 S08-DE-d1-JUN-exp1 277 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 420 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 340 bp overlap

JUN::JUNB 3 datasets

Motif DE_48h DE_48h-JUNJUNB_MA1132.2 8 bp overlap

Motif DE_48h DE_48h-JUNJUNB_MA1133.2 11 bp overlap

Motif DE_72h DE_72h-JUNJUNB_MA1132.2 8 bp overlap

JUNB 3 datasets

Motif DE_48h DE_48h-JUNB_MA0490.3 9 bp overlap

Motif DE_48h DE_48h-JUNB_MA1140.3 11 bp overlap

Motif DE_72h DE_72h-JUNB_MA0490.3 9 bp overlap

Jun 2 datasets

Motif DE_48h DE_48h-Jun_MA0489.3 8 bp overlap

Motif DE_72h DE_72h-Jun_MA0489.3 8 bp overlap

LBX2 1 dataset

Motif DE_48h DE_48h-LBX2_MA0699.2 6 bp overlap

LHX2 1 dataset

Motif DE_48h DE_48h-LHX2_MA0700.3 6 bp overlap

MAFK 2 datasets

Motif DE_48h DE_48h-MAFK_MA0496.4 10 bp overlap

Motif DE_72h DE_72h-MAFK_MA0496.4 10 bp overlap

MAX 1 dataset

ChIP NCI-H2171 GSE41105.MAX.NCI-H2171 171 bp overlap

MEIS1 2 datasets

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

MGA 1 dataset

Motif DE_48h DE_48h-MGA_MA0801.1 8 bp overlap

MSX1 1 dataset

Motif DE_48h DE_48h-MSX1_MA0666.3 6 bp overlap

MSX2 1 dataset

Motif DE_48h DE_48h-MSX2_MA0708.3 6 bp overlap

Mafg 2 datasets

Motif DE_48h DE_48h-Mafg_MA0659.4 12 bp overlap

Motif DE_72h DE_72h-Mafg_MA0659.4 12 bp overlap

Msx3 1 dataset

Motif DE_48h DE_48h-Msx3_MA0709.2 6 bp overlap

NEUROD1 1 dataset

ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 171 bp overlap

NFKB2 1 dataset

Motif DE_72h DE_72h-NFKB2_MA0778.2 11 bp overlap

NKX3-1 1 dataset

ChIP islet ERP004003.NKX3-1.islet 156 bp overlap

NR1H4::RXRA 1 dataset

Motif DE_48h DE_48h-NR1H4RXRA_MA1146.2 13 bp overlap

NR1I2 1 dataset

Motif DE_48h DE_48h-NR1I2_MA1533.2 15 bp overlap

NR2C1 1 dataset

Motif DE_72h DE_72h-NR2C1_MA1535.2 6 bp overlap

NR2C2 1 dataset

Motif DE_72h DE_72h-NR2C2_MA1536.2 6 bp overlap

Nobox 1 dataset

Motif DE_48h DE_48h-Nobox_MA0125.2 6 bp overlap

Nr1H2 1 dataset

Motif DE_72h DE_72h-Nr1H2_MA1996.2 6 bp overlap

Nr1H4 1 dataset

Motif DE_72h DE_72h-Nr1H4_MA1110.3 6 bp overlap

Nr1h3 1 dataset

Motif DE_72h DE_72h-Nr1h3_MA2337.1 6 bp overlap

Nr1h3::Rxra 1 dataset

Motif DE_48h DE_48h-Nr1h3Rxra_MA0494.2 16 bp overlap

PGR 1 dataset

ChIP breast_tumor_Male_26 GSE104399.PGR.breast_tumor_Male_26 428 bp overlap

POU4F2 1 dataset

ChIP HNPC_DIF GSE74814.POU4F2.HNPC_DIF 141 bp overlap

Prdm15 1 dataset

Motif DE_72h DE_72h-Prdm15_MA1616.2 11 bp overlap

RAX 1 dataset

Motif DE_48h DE_48h-RAX_MA0718.2 6 bp overlap

REST 2 datasets

Motif DE_72h DE_72h-REST_MA0138.3 20 bp overlap

ChIP hippocampus GSE144226.REST.hippocampus 233 bp overlap

RREB1 1 dataset

Motif DE_72h DE_72h-RREB1_MA0073.2 19 bp overlap

Rhox11 1 dataset

Motif DE_72h DE_72h-Rhox11_MA0629.2 9 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 180 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 565 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 423 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 427 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 226 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 146 bp overlap

SMARCB1 1 dataset

ChIP hiPSC GSE124903.SMARCB1.hiPSC 201 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 345 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 454 bp overlap

SREBF1 1 dataset

Motif DE_72h DE_72h-SREBF1_MA0829.3 10 bp overlap

Six3 1 dataset

Motif DE_72h DE_72h-Six3_MA0631.2 11 bp overlap

Spz1 1 dataset

Motif DE_72h DE_72h-Spz1_MA0111.1 11 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 226 bp overlap

TBR1 1 dataset

Motif DE_48h DE_48h-TBR1_MA0802.2 9 bp overlap

TBX1 1 dataset

Motif DE_48h DE_48h-TBX1_MA0805.1 8 bp overlap

TBX15 1 dataset

Motif DE_48h DE_48h-TBX15_MA0803.1 8 bp overlap

TBX18 1 dataset

Motif DE_48h DE_48h-TBX18_MA1565.2 9 bp overlap

TBX2 1 dataset

Motif DE_48h DE_48h-TBX2_MA0688.2 9 bp overlap

TBX20 1 dataset

Motif DE_48h DE_48h-TBX20_MA0689.1 11 bp overlap

TBX21 1 dataset

Motif DE_48h DE_48h-TBX21_MA0690.3 10 bp overlap

TBX3 1 dataset

Motif DE_48h DE_48h-TBX3_MA1566.3 9 bp overlap

TBX5 1 dataset

Motif DE_48h DE_48h-TBX5_MA0807.1 8 bp overlap

TEAD1 2 datasets

Motif DE_48h DE_48h-TEAD1_MA0090.4 9 bp overlap

Motif DE_72h DE_72h-TEAD1_MA0090.4 9 bp overlap

TEAD2 2 datasets

Motif DE_48h DE_48h-TEAD2_MA1121.2 7 bp overlap

Motif DE_72h DE_72h-TEAD2_MA1121.2 7 bp overlap

TEAD3 2 datasets

Motif DE_48h DE_48h-TEAD3_MA0808.1 8 bp overlap

Motif DE_72h DE_72h-TEAD3_MA0808.1 8 bp overlap

TEAD4 2 datasets

Motif DE_48h DE_48h-TEAD4_MA0809.3 8 bp overlap

Motif DE_72h DE_72h-TEAD4_MA0809.3 8 bp overlap

TFAP4::FLI1 2 datasets

Motif DE_48h DE_48h-TFAP4FLI1_MA1967.2 14 bp overlap

Motif DE_72h DE_72h-TFAP4FLI1_MA1967.2 14 bp overlap

TRPS1 1 dataset

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

Tbx6 1 dataset

Motif DE_48h DE_48h-Tbx6_MA1567.3 9 bp overlap

ZNF140 1 dataset

Motif DE_72h DE_72h-ZNF140_MA1589.2 19 bp overlap

ZNF143 1 dataset

ChIP FLP76_T4 GSE39263.ZNF143.FLP76_T4 237 bp overlap

ZNF282 1 dataset

Motif DE_72h DE_72h-ZNF282_MA1154.2 15 bp overlap

ZNF35 1 dataset

Motif DE_48h DE_48h-ZNF35_MA2333.1 7 bp overlap

ZNF382 1 dataset

Motif DE_72h DE_72h-ZNF382_MA1594.1 24 bp overlap

ZNF528 2 datasets

Motif DE_48h DE_48h-ZNF528_MA1597.1 17 bp overlap

Motif DE_72h DE_72h-ZNF528_MA1597.1 17 bp overlap

ZNF667 1 dataset

Motif DE_72h DE_72h-ZNF667_MA1984.2 11 bp overlap

ZNF677 1 dataset

Motif DE_72h DE_72h-ZNF677_MA2101.1 12 bp overlap

ZNF680 2 datasets

Motif DE_48h DE_48h-ZNF680_MA1729.2 11 bp overlap

Motif DE_72h DE_72h-ZNF680_MA1729.2 11 bp overlap

ZNF75D 1 dataset

Motif DE_48h DE_48h-ZNF75D_MA1601.2 12 bp overlap

ZNF784 2 datasets

Motif DE_48h DE_48h-ZNF784_MA1717.2 8 bp overlap

Motif DE_72h DE_72h-ZNF784_MA1717.2 8 bp overlap

Zfp335 1 dataset

Motif DE_48h DE_48h-Zfp335_MA2002.2 7 bp overlap