This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PLXNA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLXNA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLXNA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:207,958,821–207,959,846 | 284.9 kb | Distal (>10kb) Multiome | 203 | |
| chr1:207,962,859–207,964,269 | 280.6 kb | Distal (>10kb) Multiome | 820 | |
| chr1:208,040,793–208,041,533 | 203.2 kb | Distal (>10kb) Multiome HiCAR | 20 | |
| chr1:208,054,734–208,055,741 | 189.2 kb | Distal (>10kb) Multiome HiCAR | 155 | |
| chr1:208,083,034–208,084,299 | 160.6 kb | Distal (>10kb) Multiome | 259 | |
| chr1:208,119,310–208,121,028 | 124.1 kb | Distal (>10kb) Multiome | 458 | |
| chr1:208,127,858–208,128,857 | 115.9 kb | Distal (>10kb) Multiome | 35 | |
| chr1:208,209,050–208,209,843 | 34.9 kb | Distal (>10kb) Multiome | 166 | |
| chr1:208,233,376–208,234,041 | 10.5 kb | Distal (>10kb) Multiome | 186 | |
| chr1:208,235,396–208,236,210 | 8.5 kb | Proximal (<10kb) Multiome | 429 | |
| chr1:208,238,885–208,239,046 | 5.3 kb | Proximal (<10kb) | 127 | |
| chr1:208,239,153–208,239,530 | 4.8 kb | Proximal (<10kb) | 165 | |
| chr1:208,243,018–208,244,862 | 96 bp | At TSS Multiome | 575 | |
| chr1:208,245,043–208,245,695 | 742 bp | At TSS | 411 | |
| chr1:208,252,449–208,252,687 | 8.1 kb | Proximal (<10kb) | 129 | |
| chr1:208,280,257–208,281,438 | 36.5 kb | Distal (>10kb) Multiome | 152 | |
| chr1:208,373,972–208,375,097 | 130.2 kb | Distal (>10kb) Multiome | 234 | |
| chr1:208,381,389–208,382,078 | 137.6 kb | Distal (>10kb) Multiome | 22 | |
| chr1:208,564,276–208,564,841 | 320.3 kb | Distal (>10kb) Multiome HiCAR | 126 |
Genomic view of the PLXNA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.