This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signaling and may function as a tumor suppressor in multiple carcinomas. This gene is found in a cluster with other zinc finger protein genes on the long arm of chromosome 19, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for ZNF382. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF382 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF382, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:36,331,415–36,332,377 | 273.5 kb | Distal (>10kb) Multiome | 372 | |
| chr19:36,378,606–36,379,573 | 226.2 kb | Distal (>10kb) Multiome | 839 | |
| chr19:36,418,146–36,419,031 | 186.6 kb | Distal (>10kb) Multiome | 638 | |
| chr19:36,488,856–36,490,274 | 115.7 kb | Distal (>10kb) Multiome | 991 | |
| chr19:36,527,962–36,529,500 | 76.8 kb | Distal (>10kb) Multiome | 937 | |
| chr19:36,572,622–36,573,936 | 32.0 kb | Distal (>10kb) Multiome | 1017 | |
| chr19:36,604,710–36,605,744 | 8 bp | At TSS Multiome | 657 | |
| chr19:36,666,500–36,667,489 | 61.6 kb | Distal (>10kb) Multiome | 842 | |
| chr19:36,686,842–36,688,044 | 82.2 kb | Distal (>10kb) Multiome | 876 | |
| chr19:36,771,571–36,773,224 | 166.4 kb | Distal (>10kb) Multiome | 721 | |
| chr19:36,837,900–36,839,014 | 233.1 kb | Distal (>10kb) Multiome | 855 | |
| chr19:36,849,748–36,851,333 | 245.0 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the ZNF382 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.