chr4 : 71,196,036 – 71,196,366

330 bp 79 TFs 1 linked gene

This 330 bp open chromatin element is linked to SLC4A4 and is bound by 79 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
SLC4A4		8.8 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

79 transcription factors

AR 1 dataset

ChIP fibroblast_prostate-cancer_PCDF2 GSE126852.AR.fibroblast_prostate-cancer_PCDF2 201 bp overlap

ARID1A 1 dataset

ChIP 12Z GSE129781.ARID1A.12Z 152 bp overlap

ASCL1 1 dataset

Motif DE_12h DE_12h-ASCL1_MA1100.3 8 bp overlap

ASH2L 2 datasets

ChIP H1 ENCFF399KAM 330 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 330 bp overlap

ATF3 1 dataset

ChIP primary-dermal-fibroblasts_overexpressed GSE81403.ATF3.primary-dermal-fibroblasts_overexpressed 74 bp overlap

Ascl2 1 dataset

Motif DE_12h DE_12h-Ascl2_MA0816.1 10 bp overlap

BHLHE22 1 dataset

Motif DE_12h DE_12h-BHLHE22_MA1635.2 6 bp overlap

BHLHE40 2 datasets

ChIP IMR-90 ENCFF312JYK 198 bp overlap

ChIP IMR-90 ENCSR957KYB.BHLHE40.IMR-90 235 bp overlap

BRD2 4 datasets

ChIP MDA-MB-231_JQ1 GSE116879.BRD2.MDA-MB-231_JQ1 209 bp overlap

ChIP MDA-MB-231_JQ1_MGSK2801 GSE116879.BRD2.MDA-MB-231_JQ1_MGSK2801 152 bp overlap

ChIP MDA-MB-231_JQ1_MGSK2801_rDNA GSE116879.BRD2.MDA-MB-231_JQ1_MGSK2801_rDNA 152 bp overlap

ChIP MDA-MB-231_JQ1_rDNA GSE116879.BRD2.MDA-MB-231_JQ1_rDNA 209 bp overlap

BRD4 7 datasets

ChIP IMR-90_QUIES GSE74238.BRD4.IMR-90_QUIES 276 bp overlap

ChIP MDA-MB-231_JQ1 GSE116879.BRD4.MDA-MB-231_JQ1 277 bp overlap

ChIP MDA-MB-231_JQ1_MGSK2801 GSE116879.BRD4.MDA-MB-231_JQ1_MGSK2801 125 bp overlap

ChIP MDA-MB-231_JQ1_MGSK2801_rDNA GSE116879.BRD4.MDA-MB-231_JQ1_MGSK2801_rDNA 125 bp overlap

ChIP MDA-MB-231_JQ1_rDNA GSE116879.BRD4.MDA-MB-231_JQ1_rDNA 277 bp overlap

ChIP MDA-MB-231_MGSK2801_rDNA GSE116879.BRD4.MDA-MB-231_MGSK2801_rDNA 193 bp overlap

ChIP SUM159PT_100nMtrametinib_72h GSE87418.BRD4.SUM159PT_100nMtrametinib_72h 330 bp overlap

Bhlha15 1 dataset

Motif DE_12h DE_12h-Bhlha15_MA1472.3 8 bp overlap

CHD1 1 dataset

ChIP IMR-90 ENCSR000EFC.CHD1.IMR-90 260 bp overlap

CHD7 1 dataset

ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 304 bp overlap

CRY2 1 dataset

ChIP U2OS GSE130602.CRY2.U2OS 192 bp overlap

EP300 1 dataset

ChIP fibroblast_senescent GSE106146.EP300.fibroblast_senescent 145 bp overlap

ERG 1 dataset

ChIP VCaP GSE49091.ERG.VCaP 134 bp overlap

ESRRG 1 dataset

ChIP cardiomyocyte GSE113760.ESRRG.cardiomyocyte 253 bp overlap

ETV6 1 dataset

ChIP Reh_pCCL-ETV6-HA GSE102785.ETV6.Reh_pCCL-ETV6-HA 255 bp overlap

EZH2 1 dataset

ChIP GM23248 ENCFF506FWX 202 bp overlap

EZH2_phosphoT487 1 dataset

ChIP GM23248 ENCSR096KPA.EZH2_phosphoT487.GM23248 95 bp overlap

FOS 2 datasets

ChIP IMR-90 ENCFF179EDA 297 bp overlap

ChIP IMR-90 ENCSR124AIG.FOS.IMR-90 239 bp overlap

FOSL2 1 dataset

ChIP NPC_R1159Q GSE122631.FOSL2.NPC_R1159Q 159 bp overlap

FOXA2 2 datasets

ChIP BJ1-hTERT_CDT1 GSE92491.FOXA2.BJ1-hTERT_CDT1 209 bp overlap

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.FOXA2.BJ1-hTERT_FOXA2_GATA4_Coexp 165 bp overlap

GATA2 3 datasets

ChIP ESF GSE108408.GATA2.ESF 117 bp overlap

ChIP dermal-fibroblast_alone GSE51025.GATA2.dermal-fibroblast_alone 161 bp overlap

ChIP primary-endometrial-stromal-cell_IVD_P2 GSE145673.GATA2.primary-endometrial-stromal-cell_IVD_P2 218 bp overlap

GATA4 1 dataset

ChIP DE DE-GATA4-2 170 bp overlap

GATA6 3 datasets

ChIP DE DE-GATA6-2 93 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 210 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 231 bp overlap

GPS2 1 dataset

ChIP hMADS_D0_E GSE152517.GPS2.hMADS_D0_E 177 bp overlap

GRHL2 1 dataset

ChIP LNCaP GSE80256.GRHL2.LNCaP 240 bp overlap

HNF4A 1 dataset

ChIP gastric-epithelial-cell_OE GSE114018.HNF4A.gastric-epithelial-cell_OE 156 bp overlap

MAF::NFE2 1 dataset

Motif DE_12h DE_12h-MAFNFE2_MA0501.2 11 bp overlap

MAFG::NFE2L1 1 dataset

Motif DE_12h DE_12h-MAFGNFE2L1_MA0089.3 11 bp overlap

MAX 1 dataset

ChIP WA01 ENCSR000EUP.MAX.WA01 222 bp overlap

MAZ 1 dataset

ChIP IMR-90 ENCSR000EFF.MAZ.IMR-90 102 bp overlap

MED1 8 datasets

ChIP hMSC-TERT4_4h GSE104537.MED1.hMSC-TERT4_4h 266 bp overlap

ChIP hMSC-TERT4_D0 GSE104537.MED1.hMSC-TERT4_D0 194 bp overlap

ChIP hMSC-TERT4_adipocyte-4H GSE113253.MED1.hMSC-TERT4_adipocyte-4H 238 bp overlap

ChIP hMSC-TERT4_osteoblast-4H GSE113253.MED1.hMSC-TERT4_osteoblast-4H 230 bp overlap

ChIP hMSC-TERT4_osteoblast-D1 GSE113253.MED1.hMSC-TERT4_osteoblast-D1 242 bp overlap

ChIP hMSC-TERT4_osteoblast-D3 GSE113253.MED1.hMSC-TERT4_osteoblast-D3 261 bp overlap

ChIP hMSC-TERT4_osteoblast-D7 GSE113253.MED1.hMSC-TERT4_osteoblast-D7 253 bp overlap

ChIP hMSC-TERT4_undifferentiated GSE113253.MED1.hMSC-TERT4_undifferentiated 330 bp overlap

MYB 1 dataset

Motif DE_12h DE_12h-MYB_MA0100.4 6 bp overlap

MYBL2 1 dataset

Motif DE_12h DE_12h-MYBL2_MA0777.1 15 bp overlap

MYF5 2 datasets

Motif DE_12h DE_12h-MYF5_MA1641.2 8 bp overlap

ChIP Rh18 GSE84628.MYF5.Rh18 228 bp overlap

MYOD1 2 datasets

Motif DE_12h DE_12h-MYOD1_MA0499.3 9 bp overlap

ChIP myoblast GSE50413.MYOD1.myoblast 193 bp overlap

MYOG 1 dataset

Motif DE_12h DE_12h-MYOG_MA0500.3 8 bp overlap

NANOG 6 datasets

ChIP H1 ENCFF747ZPQ 176 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 292 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 227 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 239 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 330 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 193 bp overlap

NCAPH2 4 datasets

ChIP IMR-90_Triptolide-30min GSE118494.NCAPH2.IMR-90_Triptolide-30min 107 bp overlap

ChIP IMR-90_Triptolide-5min GSE118494.NCAPH2.IMR-90_Triptolide-5min 329 bp overlap

ChIP IMR-90_alpha-amanitin-30min GSE118494.NCAPH2.IMR-90_alpha-amanitin-30min 140 bp overlap

ChIP IMR-90_ctrl_OIS GSE118494.NCAPH2.IMR-90_ctrl_OIS 242 bp overlap

NCOA2 1 dataset

ChIP MCF-7_E2 ERP000901.NCOA2.MCF-7_E2 118 bp overlap

NHLH1 1 dataset

Motif DE_12h DE_12h-NHLH1_MA0048.3 9 bp overlap

NKX2-1 1 dataset

ChIP NCI-H3122 GSE39998.NKX2-1.NCI-H3122 127 bp overlap

NKX2-2 1 dataset

Motif DE_12h DE_12h-NKX2-2_MA1645.2 8 bp overlap

NKX2-5 3 datasets

Motif DE_12h DE_12h-NKX2-5_MA0063.3 7 bp overlap

ChIP hESC_ab3584 GSE89457.NKX2-5.hESC_ab3584 177 bp overlap

ChIP hESC_sc-14033 GSE89457.NKX2-5.hESC_sc-14033 140 bp overlap

NR3C1 1 dataset

ChIP IMR-90 ERP007093.NR3C1.IMR-90 176 bp overlap

Neurod2 1 dataset

Motif DE_12h DE_12h-Neurod2_MA1993.2 6 bp overlap

Olig2 1 dataset

Motif DE_12h DE_12h-Olig2_MA1997.2 6 bp overlap

POLR2A 1 dataset

ChIP thyroid gland ENCFF979LRR 319 bp overlap

PPARG 1 dataset

ChIP ASC GSE21366.PPARG.ASC 176 bp overlap

Ptf1A 1 dataset

Motif DE_12h DE_12h-Ptf1A_MA1619.2 8 bp overlap

RAD21 2 datasets

ChIP IMR-90 ENCSR000EFJ.RAD21.IMR-90 203 bp overlap

ChIP SLK_CTCF-KD GSE138105.RAD21.SLK_CTCF-KD 330 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 330 bp overlap

RCOR1 1 dataset

ChIP IMR-90 ENCSR000EFG.RCOR1.IMR-90 202 bp overlap

RNF2 2 datasets

ChIP SYO-1_shCt GSE139053.RNF2.SYO-1_shCt 151 bp overlap

ChIP fibroblast GSE139053.RNF2.fibroblast 170 bp overlap

RUNX2 1 dataset

ChIP PER-117 GSE151819.RUNX2.PER-117 254 bp overlap

RUVBL2 2 datasets

ChIP U2OS_DMSO GSE130507.RUVBL2.U2OS_DMSO 244 bp overlap

ChIP U2OS_cordycepin GSE130507.RUVBL2.U2OS_cordycepin 255 bp overlap

Runx1 1 dataset

Motif DE_12h DE_12h-Runx1_MA0002.3 9 bp overlap

SMAD3 1 dataset

ChIP NCI-H441 GSE51509.SMAD3.NCI-H441 90 bp overlap

SMARCA2 1 dataset

ChIP NPC_K755R-siCT GSE122631.SMARCA2.NPC_K755R-siCT 207 bp overlap

SMARCA4 6 datasets

ChIP A-549_AG15678 GSE132290.SMARCA4.A-549_AG15678 93 bp overlap

ChIP A-549_AG15688 GSE132290.SMARCA4.A-549_AG15688 141 bp overlap

ChIP A-549_AG15720 GSE132290.SMARCA4.A-549_AG15720 103 bp overlap

ChIP NPC_siCT GSE122631.SMARCA4.NPC_siCT 294 bp overlap

ChIP NPC_siSOX GSE122631.SMARCA4.NPC_siSOX 233 bp overlap

ChIP endometrial-epithelial-cells_KO GSE106660.SMARCA4.endometrial-epithelial-cells_KO 244 bp overlap

SMC3 1 dataset

ChIP IMR-90 ENCSR000HPG.SMC3.IMR-90 228 bp overlap

SP1 2 datasets

ChIP H1 ENCFF263FUH 321 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 261 bp overlap

SUZ12 1 dataset

ChIP Karpas-422_CPI360-D4 GSE134136.SUZ12.Karpas-422_CPI360-D4 194 bp overlap

Spz1 1 dataset

Motif DE_12h DE_12h-Spz1_MA0111.1 11 bp overlap

TCF12 1 dataset

ChIP WA01 ENCSR000BIT.TCF12.WA01 128 bp overlap

TCF21 1 dataset

ChIP HCASMC GSE124011.TCF21.HCASMC 207 bp overlap

TEAD1 2 datasets

ChIP HUCCT1 GSE68296.TEAD1.HUCCT1 138 bp overlap

ChIP adipocyte GSE140782.TEAD1.adipocyte 229 bp overlap

TEAD4 2 datasets

Motif DE_12h DE_12h-TEAD4_MA0809.3 8 bp overlap

ChIP H1 ENCFF778PAX 245 bp overlap

TFAP2C 1 dataset

ChIP HCC1954 GSE126897.TFAP2C.HCC1954 239 bp overlap

TWIST1 2 datasets

ChIP SHEP-21N GSE80151.TWIST1.SHEP-21N 136 bp overlap

ChIP SHEP-21N_DOX_0H GSE80151.TWIST1.SHEP-21N_DOX_0H 136 bp overlap

Tcf12 1 dataset

Motif DE_12h DE_12h-Tcf12_MA0521.3 6 bp overlap

Twist2 1 dataset

Motif DE_12h DE_12h-Twist2_MA0633.3 6 bp overlap

VDR 1 dataset

ChIP LX2_CALCIPOTRIOL_TGFB1 GSE38103.VDR.LX2_CALCIPOTRIOL_TGFB1 171 bp overlap

YAP1 1 dataset

ChIP MCF-10A GSE97972.YAP1.MCF-10A 174 bp overlap

YY1 2 datasets

ChIP H1 ENCFF524BTL 307 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 281 bp overlap

ZNF462 2 datasets

ChIP GM23338 ENCFF896CCA 215 bp overlap

ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 172 bp overlap

ZNF85 1 dataset

Motif DE_12h DE_12h-ZNF85_MA1720.2 12 bp overlap