GPS2
G protein pathway suppressor 2

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]

Member of: DE-1
Biological processes 52 terms
B cell differentiation (GO:0030183)B cell differentiation (GO:0030183)GTPase inhibitor activity (GO:0005095)JNK cascade (GO:0007254)cyclin binding (GO:0030332)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of B cell receptor signaling pathway (GO:0050859)negative regulation of B cell receptor signaling pathway (GO:0050859)negative regulation of JNK cascade (GO:0046329)negative regulation of JNK cascade (GO:0046329)negative regulation of fat cell differentiation (GO:0045599)negative regulation of fat cell differentiation (GO:0045599)negative regulation of inflammatory response (GO:0050728)negative regulation of inflammatory response (GO:0050728)negative regulation of protein K63-linked ubiquitination (GO:1900045)negative regulation of protein K63-linked ubiquitination (GO:1900045)negative regulation of toll-like receptor signaling pathway (GO:0034122)negative regulation of toll-like receptor signaling pathway (GO:0034122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of cholesterol efflux (GO:0010875)positive regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035360)positive regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035360)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of fat cell differentiation (GO:0045598)regulation of fat cell differentiation (GO:0045598)regulation of lipid metabolic process (GO:0019216)regulation of lipid metabolic process (GO:0019216)regulation of transcription by RNA polymerase II (GO:0006357)response to mitochondrial depolarisation (GO:0098780)response to mitochondrial depolarisation (GO:0098780)transcription coactivator activity (GO:0003713)transcription coactivator activity (GO:0003713)transcription coregulator activity (GO:0003712)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)transcription regulator complex (GO:0005667)transcription repressor complex (GO:0017053)transcription repressor complex (GO:0017053)
Expression (TPM)
GPS2 — as a Regulated Gene

TFs regulating GPS2 0 TFs

Transcription factors with Perturb-seq knockdown data for GPS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to GPS2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:7,014,335–7,015,213 300.5 kb Distal (>10kb) Multiome 842
chr17:7,021,831–7,024,265 291.5 kb Distal (>10kb) Multiome 614
chr17:7,035,527–7,036,637 279.4 kb Distal (>10kb) Multiome 791
chr17:7,132,532–7,133,109 182.5 kb Distal (>10kb) Multiome 312
chr17:7,177,263–7,177,909 137.8 kb Distal (>10kb) Multiome 453
chr17:7,204,820–7,205,551 110.2 kb Distal (>10kb) Multiome 364
chr17:7,207,943–7,208,476 107.1 kb Distal (>10kb) Multiome 91
chr17:7,213,858–7,216,461 100.9 kb Distal (>10kb) Multiome 737
chr17:7,219,603–7,220,515 95.4 kb Distal (>10kb) Multiome 793
chr17:7,233,847–7,235,210 80.8 kb Distal (>10kb) Multiome 1020
chr17:7,237,531–7,238,757 77.4 kb Distal (>10kb) Multiome 502
chr17:7,238,867–7,240,155 75.7 kb Distal (>10kb) Multiome 783
chr17:7,241,494–7,243,462 72.3 kb Distal (>10kb) Multiome 1037
chr17:7,251,263–7,252,962 63.2 kb Distal (>10kb) Multiome 985
chr17:7,260,746–7,263,748 52.7 kb Distal (>10kb) Multiome 639
chr17:7,280,161–7,282,555 33.7 kb Distal (>10kb) Multiome 841
chr17:7,293,901–7,295,189 20.6 kb Distal (>10kb) Multiome 443
chr17:7,296,224–7,296,683 18.8 kb Distal (>10kb) Multiome 688
chr17:7,306,788–7,309,027 8.0 kb Proximal (<10kb) Multiome 896
chr17:7,314,722–7,315,725 18 bp At TSS Multiome 843
chr17:7,324,275–7,324,457 9.5 kb Proximal (<10kb) 177
chr17:7,328,881–7,330,972 14.1 kb Distal (>10kb) Multiome 809
chr17:7,349,378–7,350,590 34.9 kb Distal (>10kb) Multiome 414
chr17:7,351,208–7,352,575 36.7 kb Distal (>10kb) Multiome 857
chr17:7,356,082–7,356,523 40.9 kb Distal (>10kb) Multiome 485
chr17:7,383,791–7,384,537 68.9 kb Distal (>10kb) Multiome 218
chr17:7,393,924–7,395,223 79.3 kb Distal (>10kb) Multiome 744
chr17:7,403,290–7,405,695 89.0 kb Distal (>10kb) Multiome 838
chr17:7,435,167–7,437,681 121.8 kb Distal (>10kb) Multiome 828
chr17:7,437,892–7,438,555 123.0 kb Distal (>10kb) Multiome 224
chr17:7,440,048–7,441,211 125.4 kb Distal (>10kb) Multiome 487
chr17:7,444,968–7,446,142 130.2 kb Distal (>10kb) Multiome 632
chr17:7,455,450–7,456,019 140.3 kb Distal (>10kb) Multiome 414
chr17:7,478,839–7,480,126 164.2 kb Distal (>10kb) Multiome 574
chr17:7,483,139–7,485,576 169.1 kb Distal (>10kb) Multiome 1156
chr17:7,548,693–7,549,285 233.7 kb Distal (>10kb) Multiome 387
chr17:7,560,249–7,562,536 246.6 kb Distal (>10kb) Multiome 759
chr17:7,572,039–7,574,418 258.5 kb Distal (>10kb) Multiome 1071
chr17:7,579,018–7,579,876 264.1 kb Distal (>10kb) Multiome HiCAR 844
chr17:7,583,063–7,584,547 268.4 kb Distal (>10kb) Multiome 921
chr17:7,588,871–7,590,534 274.8 kb Distal (>10kb) Multiome 319
chr17:7,614,065–7,615,780 299.8 kb Distal (>10kb) Multiome 708

Genome Browser

Genomic view of the GPS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:7,004,335 – 7,625,780
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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