RUVBL2

RuvB like AAA ATPase 2 | ECP51, INO80J, RVB2, Reptin52, Rvb2, TIH2, TIP48, TIP49b

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.8 Developmental clusters: GC1

Biological processes 89 terms

ADP binding (GO:0043531)ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)ATP-dependent activity, acting on DNA (GO:0008094)ATPase binding (GO:0051117)DNA helicase activity (GO:0003678)DNA helicase activity (GO:0003678)DNA helicase activity (GO:0003678)DNA helicase activity (GO:0003678)DNA recombination (GO:0006310)DNA repair (GO:0006281)Ino80 complex (GO:0031011)Ino80 complex (GO:0031011)MLL1 complex (GO:0071339)MLL1 complex (GO:0071339)NuA4 histone acetyltransferase complex (GO:0035267)NuA4 histone acetyltransferase complex (GO:0035267)NuA4 histone acetyltransferase complex (GO:0035267)R2TP complex (GO:0097255)R2TP complex (GO:0097255)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979)RPAP3/R2TP/prefoldin-like complex (GO:1990062)Swr1 complex (GO:0000812)Swr1 complex (GO:0000812)TBP-class protein binding (GO:0017025)TBP-class protein binding (GO:0017025)TFIID-class transcription factor complex binding (GO:0001094)beta-catenin binding (GO:0008013)box C/D snoRNP assembly (GO:0000492)cellular response to UV (GO:0034644)cellular response to estradiol stimulus (GO:0071392)chromatin DNA binding (GO:0031490)chromatin remodeling (GO:0006338)chromatin remodeling (GO:0006338)chromatin remodeling (GO:0006338)chromatin remodeling (GO:0006338)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)dynein axonemal particle (GO:0120293)dynein axonemal particle (GO:0120293)establishment of protein localization to chromatin (GO:0071169)euchromatin (GO:0000791)extracellular exosome (GO:0070062)identical protein binding (GO:0042802)identical protein binding (GO:0042802)membrane (GO:0016020)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of canonical Wnt signaling pathway (GO:0090090)nuclear matrix (GO:0016363)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleosome (GO:0000786)nucleus (GO:0005634)positive regulation of DNA repair (GO:0045739)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of double-strand break repair via homologous recombination (GO:1905168)positive regulation of double-strand break repair via homologous recombination (GO:1905168)positive regulation of telomere maintenance in response to DNA damage (GO:1904507)positive regulation of transcription by RNA polymerase II (GO:0045944)promoter-enhancer loop anchoring activity (GO:0140585)protein binding (GO:0005515)protein folding (GO:0006457)protein folding chaperone complex (GO:0101031)protein homodimerization activity (GO:0042803)protein stabilization (GO:0050821)regulation of DNA repair (GO:0006282)regulation of DNA replication (GO:0006275)regulation of DNA replication (GO:0006275)regulation of DNA strand elongation (GO:0060382)regulation of DNA strand elongation (GO:0060382)regulation of DNA-templated transcription (GO:0006355)regulation of apoptotic process (GO:0042981)regulation of cell cycle (GO:0051726)regulation of chromosome organization (GO:0033044)regulation of chromosome organization (GO:0033044)regulation of double-strand break repair (GO:2000779)regulation of embryonic development (GO:0045995)regulation of transcription by RNA polymerase II (GO:0006357)ribonucleoprotein complex (GO:1990904)telomerase RNA localization to Cajal body (GO:0090671)telomere maintenance (GO:0000723)transcription corepressor activity (GO:0003714)unfolded protein binding (GO:0051082)

Expression (TPM)

TFs regulating RUVBL2 0 TFs

Transcription factors with Perturb-seq knockdown data for RUVBL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RUVBL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RUVBL2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RUVBL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:48,645,454–48,647,163	347.3 kb	Distal (>10kb) Multiome HiCAR	750
chr19:48,695,830–48,697,033	297.8 kb	Distal (>10kb) Multiome	253
chr19:48,713,646–48,714,846	279.6 kb	Distal (>10kb) Multiome	719
chr19:48,716,551–48,717,038	277.0 kb	Distal (>10kb) Multiome	241
chr19:48,720,420–48,721,301	273.0 kb	Distal (>10kb) Multiome	689
chr19:48,735,001–48,735,602	258.6 kb	Distal (>10kb) Multiome	161
chr19:48,738,441–48,739,812	255.0 kb	Distal (>10kb) Multiome	743
chr19:48,741,194–48,741,939	252.3 kb	Distal (>10kb) Multiome	350
chr19:48,746,830–48,747,395	246.8 kb	Distal (>10kb) Multiome	402
chr19:48,752,314–48,753,547	241.0 kb	Distal (>10kb) Multiome	545
chr19:48,795,165–48,795,736	198.4 kb	Distal (>10kb) Multiome	724
chr19:48,806,734–48,807,478	186.9 kb	Distal (>10kb) Multiome	452
chr19:48,810,774–48,811,494	182.9 kb	Distal (>10kb) Multiome	662
chr19:48,812,048–48,813,099	181.4 kb	Distal (>10kb) Multiome	603
chr19:48,829,998–48,830,690	163.6 kb	Distal (>10kb) Multiome	55
chr19:48,835,571–48,838,073	158.1 kb	Distal (>10kb) Multiome	621
chr19:48,872,000–48,873,835	121.5 kb	Distal (>10kb) Multiome	987
chr19:48,895,958–48,896,628	97.6 kb	Distal (>10kb) Multiome	207
chr19:48,899,782–48,900,620	93.6 kb	Distal (>10kb) Multiome	710
chr19:48,933,397–48,933,948	60.3 kb	Distal (>10kb) Multiome	458
chr19:48,954,440–48,955,356	39.0 kb	Distal (>10kb) Multiome	905
chr19:48,963,322–48,964,187	30.1 kb	Distal (>10kb) Multiome	866
chr19:48,964,515–48,966,446	28.6 kb	Distal (>10kb) Multiome	1015
chr19:48,992,286–48,992,511	1.4 kb	Proximal (<10kb)	107
chr19:48,992,571–48,994,129	336 bp	At TSS Multiome	852
chr19:48,999,848–49,000,018	6.0 kb	Proximal (<10kb)	161
chr19:49,017,642–49,018,292	24.0 kb	Distal (>10kb) Multiome	480
chr19:49,019,277–49,019,889	25.7 kb	Distal (>10kb) Multiome	233
chr19:49,055,975–49,056,714	62.4 kb	Distal (>10kb) Multiome	431
chr19:49,064,668–49,065,682	71.2 kb	Distal (>10kb) Multiome	226
chr19:49,071,761–49,072,903	78.1 kb	Distal (>10kb) Multiome	278
chr19:49,084,646–49,086,115	91.5 kb	Distal (>10kb) Multiome	1030
chr19:49,113,727–49,115,240	121.2 kb	Distal (>10kb) Multiome	746
chr19:49,118,477–49,120,300	125.3 kb	Distal (>10kb) Multiome	949
chr19:49,127,647–49,128,949	134.3 kb	Distal (>10kb) Multiome	1000
chr19:49,129,106–49,129,678	135.7 kb	Distal (>10kb) Multiome	197
chr19:49,132,975–49,134,197	139.6 kb	Distal (>10kb) Multiome	179
chr19:49,142,781–49,143,252	149.2 kb	Distal (>10kb) Multiome	299
chr19:49,145,727–49,146,720	152.3 kb	Distal (>10kb) Multiome	511
chr19:49,148,659–49,150,947	156.7 kb	Distal (>10kb) Multiome	917
chr19:49,151,539–49,152,548	158.1 kb	Distal (>10kb) Multiome	497
chr19:49,157,555–49,158,336	163.9 kb	Distal (>10kb) Multiome	599
chr19:49,210,032–49,211,225	216.7 kb	Distal (>10kb) Multiome	366

Genome Browser

Genomic view of the RUVBL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.