chr1:45,926,675–45,927,764

chr1 : 45,926,675 – 45,927,764

1,089 bp 127 TFs 7 linked genes

This 1.1 kb open chromatin element is linked to 7 target genes and is bound by 127 transcription factors.

Linked Genes

7 genes

Gene	Expression	Dist. to TSS	Distance	Link type
MAST2		123.8 kb	Distal	Multiome
IPP		176.7 kb	Distal	Multiome
PIK3R3		205.5 kb	Distal	Multiome
TMEM69		239.2 kb	Distal	Multiome
GPBP1L1		240.8 kb	Distal	Multiome
POMGNT1		271.0 kb	Distal	Multiome
LURAP1		276.0 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

127 transcription factors

Ahr::Arnt 2 datasets

Motif DE_12h DE_12h-AhrArnt_MA0006.2 5 bp overlap

Motif DE_24h DE_24h-AhrArnt_MA0006.2 5 bp overlap

Arid3a 2 datasets

Motif DE_12h DE_12h-Arid3a_MA0151.1 6 bp overlap

Motif DE_24h DE_24h-Arid3a_MA0151.1 6 bp overlap

BCL11A 1 dataset

Motif DE_24h DE_24h-BCL11A_MA2324.1 7 bp overlap

ChIP LNCaP-C4-2_OE GSE88871.BRD4.LNCaP-C4-2_OE 117 bp overlap

Motif DE_24h DE_24h-CDX1_MA0878.3 10 bp overlap

ChIP WA01 ENCSR000AQK.CHD1.WA01 154 bp overlap

ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 50 bp overlap

Motif DE_24h DE_24h-Crx_MA0467.3 6 bp overlap

Motif DE_24h DE_24h-DPRX_MA1480.2 9 bp overlap

Dmbx1 1 dataset

Motif DE_24h DE_24h-Dmbx1_MA0883.2 10 bp overlap

Motif DE_24h DE_24h-E2F6_MA0471.3 8 bp overlap

Motif DE_24h DE_24h-E2F7_MA0758.1 14 bp overlap

Motif DE_24h DE_24h-E2F8_MA0865.3 9 bp overlap

Motif DE_24h DE_24h-ETV2_MA0762.2 9 bp overlap

ETV5::FOXO1 1 dataset

Motif DE_24h DE_24h-ETV5FOXO1_MA1947.2 10 bp overlap

FEZF2 1 dataset

Motif DE_24h DE_24h-FEZF2_MA2341.1 8 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 372 bp overlap

Motif DE_24h DE_24h-FOXA2_MA0047.4 8 bp overlap

FOXK1 1 dataset

Motif DE_24h DE_24h-FOXK1_MA0852.3 7 bp overlap

FOXK2 1 dataset

Motif DE_24h DE_24h-FOXK2_MA1103.3 7 bp overlap

FOXL1 1 dataset

Motif DE_24h DE_24h-FOXL1_MA0033.2 7 bp overlap

FOXO4 1 dataset

Motif DE_24h DE_24h-FOXO4_MA0848.1 7 bp overlap

FOXO6 1 dataset

Motif DE_24h DE_24h-FOXO6_MA0849.1 7 bp overlap

FOXP2 1 dataset

Motif DE_24h DE_24h-FOXP2_MA0593.2 9 bp overlap

FOXP3 1 dataset

Motif DE_24h DE_24h-FOXP3_MA0850.1 7 bp overlap

FOXS1 1 dataset

Motif DE_24h DE_24h-FOXS1_MA2118.1 8 bp overlap

Foxf1 1 dataset

Motif DE_24h DE_24h-Foxf1_MA1606.2 7 bp overlap

Foxo1 1 dataset

Motif DE_24h DE_24h-Foxo1_MA0480.3 7 bp overlap

Foxo3 1 dataset

Motif DE_24h DE_24h-Foxo3_MA0157.4 7 bp overlap

Foxq1 1 dataset

Motif DE_24h DE_24h-Foxq1_MA0040.2 10 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 763 bp overlap

ChIP DE DE-GATA4-2 732 bp overlap

Motif DE_24h DE_24h-GATA4_MA0482.3 8 bp overlap

GATA5 1 dataset

Motif DE_24h DE_24h-GATA5_MA0766.3 8 bp overlap

GATA6 10 datasets

ChIP DE DE-GATA6-1 395 bp overlap

ChIP DE DE-GATA6-1 198 bp overlap

ChIP DE DE-GATA6-2 849 bp overlap

Motif DE_24h DE_24h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 821 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 899 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 1060 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 796 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 482 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 292 bp overlap

Motif DE_24h DE_24h-GSC_MA0648.2 6 bp overlap

Motif DE_24h DE_24h-GSC2_MA0891.2 6 bp overlap

Gata3 1 dataset

Motif DE_24h DE_24h-Gata3_MA0037.5 8 bp overlap

HOXB4 2 datasets

Motif DE_12h DE_12h-HOXB4_MA1499.2 6 bp overlap

Motif DE_24h DE_24h-HOXB4_MA1499.2 6 bp overlap

HOXC4 2 datasets

Motif DE_12h DE_12h-HOXC4_MA1504.2 6 bp overlap

Motif DE_24h DE_24h-HOXC4_MA1504.2 6 bp overlap

HOXD4 2 datasets

Motif DE_12h DE_12h-HOXD4_MA1507.2 6 bp overlap

Motif DE_24h DE_24h-HOXD4_MA1507.2 6 bp overlap

HSF1 2 datasets

Motif DE_12h DE_12h-HSF1_MA0486.2 13 bp overlap

Motif DE_24h DE_24h-HSF1_MA0486.2 13 bp overlap

HSF4 2 datasets

Motif DE_12h DE_12h-HSF4_MA0771.1 13 bp overlap

Motif DE_24h DE_24h-HSF4_MA0771.1 13 bp overlap

Hmga1 2 datasets

Motif DE_12h DE_12h-Hmga1_MA2124.1 8 bp overlap

Motif DE_24h DE_24h-Hmga1_MA2124.1 8 bp overlap

Hnf1A 1 dataset

Motif DE_24h DE_24h-Hnf1A_MA1991.2 10 bp overlap

Hoxa13 1 dataset

Motif DE_24h DE_24h-Hoxa13_MA0650.4 8 bp overlap

IKZF1 1 dataset

Motif DE_24h DE_24h-IKZF1_MA1508.2 8 bp overlap

IKZF2 1 dataset

Motif DE_24h DE_24h-IKZF2_MA2326.1 6 bp overlap

IRF7 2 datasets

Motif DE_12h DE_12h-IRF7_MA0772.2 13 bp overlap

Motif DE_24h DE_24h-IRF7_MA0772.2 13 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 982 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 69 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 693 bp overlap

ChIP ESC S24-ESC-d0-JUN-exp1 421 bp overlap

KLF1 2 datasets

Motif DE_12h DE_12h-KLF1_MA0493.3 8 bp overlap

Motif DE_24h DE_24h-KLF1_MA0493.3 8 bp overlap

KLF10 2 datasets

Motif DE_12h DE_12h-KLF10_MA1511.2 9 bp overlap

Motif DE_24h DE_24h-KLF10_MA1511.2 9 bp overlap

KLF11 2 datasets

Motif DE_12h DE_12h-KLF11_MA1512.2 10 bp overlap

Motif DE_24h DE_24h-KLF11_MA1512.2 10 bp overlap

KLF12 2 datasets

Motif DE_12h DE_12h-KLF12_MA0742.2 9 bp overlap

Motif DE_24h DE_24h-KLF12_MA0742.2 9 bp overlap

KLF14 2 datasets

Motif DE_12h DE_12h-KLF14_MA0740.2 9 bp overlap

Motif DE_24h DE_24h-KLF14_MA0740.2 9 bp overlap

KLF2 2 datasets

Motif DE_12h DE_12h-KLF2_MA1515.2 8 bp overlap

Motif DE_24h DE_24h-KLF2_MA1515.2 8 bp overlap

KLF3 2 datasets

Motif DE_12h DE_12h-KLF3_MA1516.2 10 bp overlap

Motif DE_24h DE_24h-KLF3_MA1516.2 10 bp overlap

KLF5 2 datasets

Motif DE_12h DE_12h-KLF5_MA0599.1 10 bp overlap

Motif DE_24h DE_24h-KLF5_MA0599.1 10 bp overlap

KLF6 2 datasets

Motif DE_12h DE_12h-KLF6_MA1517.2 9 bp overlap

Motif DE_24h DE_24h-KLF6_MA1517.2 9 bp overlap

KLF7 2 datasets

Motif DE_12h DE_12h-KLF7_MA1959.2 8 bp overlap

Motif DE_24h DE_24h-KLF7_MA1959.2 8 bp overlap

KLF9 2 datasets

Motif DE_12h DE_12h-KLF9_MA1107.3 11 bp overlap

Motif DE_24h DE_24h-KLF9_MA1107.3 11 bp overlap

ChIP hESC_PRIMED GSE69646.MED1.hESC_PRIMED 204 bp overlap

MEIS1 3 datasets

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

Motif DE_24h DE_24h-MEIS1_MA0498.3 5 bp overlap

Motif DE_24h DE_24h-MEIS1_MA0498.3 5 bp overlap

Msgn1 1 dataset

Motif DE_24h DE_24h-Msgn1_MA1524.3 10 bp overlap

NANOG 3 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 439 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 338 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 150 bp overlap

Motif DE_24h DE_24h-NFIA_MA0670.2 6 bp overlap

Motif DE_24h DE_24h-NFIB_MA1643.2 17 bp overlap

NFIC 3 datasets

Motif DE_24h DE_24h-NFIC_MA1527.2 15 bp overlap

ChIP Ishikawa ENCFF029AAD 112 bp overlap

ChIP Ishikawa ENCFF029AAD 377 bp overlap

NFIC::TLX1 1 dataset

Motif DE_24h DE_24h-NFICTLX1_MA0119.1 14 bp overlap

NFIX 2 datasets

Motif DE_24h DE_24h-NFIX_MA0671.2 6 bp overlap

Motif DE_24h DE_24h-NFIX_MA1528.2 14 bp overlap

Motif DE_24h DE_24h-OTX1_MA0711.2 6 bp overlap

Motif DE_24h DE_24h-PBX3_MA1114.2 11 bp overlap

ChIP HEK293_ab833 GSE101646.PHIP.HEK293_ab833 95 bp overlap

PHOX2A 2 datasets

Motif DE_12h DE_12h-PHOX2A_MA0713.1 11 bp overlap

Motif DE_24h DE_24h-PHOX2A_MA0713.1 11 bp overlap

PHOX2B 2 datasets

Motif DE_12h DE_12h-PHOX2B_MA0681.3 12 bp overlap

Motif DE_24h DE_24h-PHOX2B_MA0681.3 12 bp overlap

PITX1 1 dataset

Motif DE_24h DE_24h-PITX1_MA0682.3 6 bp overlap

PITX3 1 dataset

Motif DE_24h DE_24h-PITX3_MA0714.2 6 bp overlap

PKNOX1 1 dataset

Motif DE_24h DE_24h-PKNOX1_MA0782.3 10 bp overlap

POU1F1 2 datasets

Motif DE_12h DE_12h-POU1F1_MA0784.3 14 bp overlap

Motif DE_24h DE_24h-POU1F1_MA0784.3 14 bp overlap

POU2F1::SOX2 2 datasets

Motif DE_12h DE_12h-POU2F1SOX2_MA1962.1 17 bp overlap

Motif DE_24h DE_24h-POU2F1SOX2_MA1962.1 17 bp overlap

POU5F1 3 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 849 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 103 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 79 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 318 bp overlap

PRDM1 3 datasets

Motif DE_24h DE_24h-PRDM1_MA0508.4 7 bp overlap

ChIP HEK293 ENCFF302TBP 105 bp overlap

ChIP HEK293 GSE76494.PRDM1.HEK293 77 bp overlap

PRDM4 2 datasets

ChIP HEK293 ENCFF069PHD 140 bp overlap

ChIP HEK293 ENCSR443MVV.PRDM4.HEK293 109 bp overlap

PROP1 2 datasets

Motif DE_12h DE_12h-PROP1_MA0715.1 11 bp overlap

Motif DE_24h DE_24h-PROP1_MA0715.1 11 bp overlap

Pou5f1::Sox2 2 datasets

Motif DE_12h DE_12h-Pou5f1Sox2_MA0142.1 15 bp overlap

Motif DE_24h DE_24h-Pou5f1Sox2_MA0142.1 15 bp overlap

Motif DE_24h DE_24h-REL_MA0101.1 10 bp overlap

Motif DE_24h DE_24h-RELA_MA0107.1 10 bp overlap

RHOXF1 1 dataset

Motif DE_24h DE_24h-RHOXF1_MA0719.2 6 bp overlap

Runx1 1 dataset

Motif DE_24h DE_24h-Runx1_MA0002.3 9 bp overlap

SATB1 2 datasets

Motif DE_24h DE_24h-SATB1_MA1963.2 7 bp overlap

Motif DE_24h DE_24h-SATB1_MA1963.2 7 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 101 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 479 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 393 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 789 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 916 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 898 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 1089 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 849 bp overlap

SMARCA4 1 dataset

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 102 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 180 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 96 bp overlap

SMARCC1 3 datasets

ChIP DE_D1 S15-DE-d1-BAF155-exp1 541 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 79 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 97 bp overlap

SOX15 2 datasets

Motif DE_12h DE_12h-SOX15_MA1152.2 7 bp overlap

Motif DE_24h DE_24h-SOX15_MA1152.2 7 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 350 bp overlap

SOX17_M 2 datasets

ChIP DE_D2 DED2-SOX17-M_Batch_II 64 bp overlap

ChIP DE_D2 DED2-SOX17-M_Batch_II 755 bp overlap

SOX21 2 datasets

Motif DE_12h DE_12h-SOX21_MA0866.1 15 bp overlap

Motif DE_24h DE_24h-SOX21_MA0866.1 15 bp overlap

Motif DE_12h DE_12h-SP3_MA0746.3 11 bp overlap

Motif DE_24h DE_24h-SP3_MA0746.3 11 bp overlap

Motif DE_12h DE_12h-SP4_MA0685.2 9 bp overlap

Motif DE_24h DE_24h-SP4_MA0685.2 9 bp overlap

Motif DE_12h DE_12h-SP9_MA1564.2 10 bp overlap

Motif DE_24h DE_24h-SP9_MA1564.2 10 bp overlap

SREBF1 1 dataset

Motif DE_24h DE_24h-SREBF1_MA0829.3 10 bp overlap

Motif DE_24h DE_24h-Six3_MA0631.2 11 bp overlap

Motif DE_24h DE_24h-Spi1_MA0080.7 13 bp overlap

Stat2 1 dataset

Motif DE_24h DE_24h-Stat2_MA1623.2 10 bp overlap

Motif DE_24h DE_24h-TBX5_MA0807.1 8 bp overlap

TEAD1 1 dataset

ChIP WTC11 ENCFF502QUV 405 bp overlap

TFAP2A 1 dataset

Motif DE_24h DE_24h-TFAP2A_MA0810.2 11 bp overlap

TFCP2 1 dataset

Motif DE_24h DE_24h-TFCP2_MA1968.2 9 bp overlap

TFDP1 1 dataset

Motif DE_24h DE_24h-TFDP1_MA1122.2 8 bp overlap

TGIF1 1 dataset

Motif DE_24h DE_24h-TGIF1_MA0796.1 12 bp overlap

TGIF2 1 dataset

Motif DE_24h DE_24h-TGIF2_MA0797.1 12 bp overlap

TGIF2LX 1 dataset

Motif DE_24h DE_24h-TGIF2LX_MA1571.1 12 bp overlap

TGIF2LY 1 dataset

Motif DE_24h DE_24h-TGIF2LY_MA1572.1 12 bp overlap

TRPS1 1 dataset

Motif DE_24h DE_24h-TRPS1_MA1970.2 8 bp overlap

VEZF1 2 datasets

Motif DE_12h DE_12h-VEZF1_MA1578.2 6 bp overlap

Motif DE_24h DE_24h-VEZF1_MA1578.2 6 bp overlap

ZBTB44 1 dataset

ChIP HEK293 ENCFF560VPN 197 bp overlap

ZIM3 2 datasets

Motif DE_24h DE_24h-ZIM3_MA1709.2 11 bp overlap

Motif DE_24h DE_24h-ZIM3_MA1709.2 11 bp overlap

ZNF257 2 datasets

Motif DE_24h DE_24h-ZNF257_MA1710.2 10 bp overlap

ChIP HEK293T GSE78099.ZNF257.HEK293T 167 bp overlap

ZNF281 1 dataset

Motif DE_24h DE_24h-ZNF281_MA1630.3 10 bp overlap

ZNF320 1 dataset

Motif DE_24h DE_24h-ZNF320_MA1976.2 20 bp overlap

ZNF341 1 dataset

Motif DE_24h DE_24h-ZNF341_MA1655.2 8 bp overlap

ZNF366 1 dataset

ChIP HEK293 ENCFF799ATK 55 bp overlap

ZNF460 1 dataset

Motif DE_24h DE_24h-ZNF460_MA1596.1 16 bp overlap

ZNF547 2 datasets

Motif DE_12h DE_12h-ZNF547_MA2334.1 13 bp overlap

Motif DE_24h DE_24h-ZNF547_MA2334.1 13 bp overlap

ZNF682 2 datasets

Motif DE_12h DE_12h-ZNF682_MA1599.2 11 bp overlap

Motif DE_24h DE_24h-ZNF682_MA1599.2 11 bp overlap

ZNF770 2 datasets

Motif DE_12h DE_12h-ZNF770_MA2099.1 8 bp overlap

Motif DE_24h DE_24h-ZNF770_MA2099.1 8 bp overlap

ZSCAN16 1 dataset

ChIP HEK293 ENCFF533NFT 244 bp overlap