The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IPP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IPP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IPP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:45,490,605–45,491,773 | 259.4 kb | Distal (>10kb) Multiome | 900 | |
| chr1:45,499,499–45,500,620 | 250.5 kb | Distal (>10kb) Multiome | 831 | |
| chr1:45,521,163–45,522,604 | 228.7 kb | Distal (>10kb) Multiome | 1155 | |
| chr1:45,550,427–45,551,304 | 199.8 kb | Distal (>10kb) Multiome | 1006 | |
| chr1:45,583,145–45,585,182 | 165.9 kb | Distal (>10kb) Multiome | 997 | |
| chr1:45,622,461–45,623,374 | 127.6 kb | Distal (>10kb) Multiome | 169 | |
| chr1:45,686,052–45,687,740 | 63.5 kb | Distal (>10kb) Multiome | 1015 | |
| chr1:45,687,860–45,688,505 | 62.3 kb | Distal (>10kb) Multiome | 861 | |
| chr1:45,750,186–45,751,093 | 58 bp | At TSS Multiome | 961 | |
| chr1:45,802,824–45,804,412 | 52.9 kb | Distal (>10kb) Multiome | 753 | |
| chr1:45,926,675–45,927,764 | 176.7 kb | Distal (>10kb) Multiome | 127 | |
| chr1:45,929,025–45,929,719 | 178.8 kb | Distal (>10kb) Multiome | 247 |
Genomic view of the IPP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.