Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for PIK3R3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIK3R3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIK3R3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:45,926,675–45,927,764 | 205.5 kb | Distal (>10kb) Multiome | 127 | |
| chr1:45,929,025–45,929,719 | 203.5 kb | Distal (>10kb) Multiome | 247 | |
| chr1:46,131,887–46,133,691 | 34 bp | At TSS Multiome | 1126 | |
| chr1:46,198,117–46,198,832 | 65.6 kb | Distal (>10kb) Multiome | 646 | |
| chr1:46,203,021–46,203,710 | 70.4 kb | Distal (>10kb) Multiome | 394 | |
| chr1:46,246,904–46,248,623 | 114.6 kb | Distal (>10kb) Multiome | 923 | |
| chr1:46,254,338–46,255,513 | 121.8 kb | Distal (>10kb) Multiome | 39 | |
| chr1:46,301,645–46,303,965 | 170.5 kb | Distal (>10kb) Multiome | 1035 | |
| chr1:46,340,061–46,341,413 | 207.8 kb | Distal (>10kb) Multiome | 967 | |
| chr1:46,394,021–46,394,849 | 261.5 kb | Distal (>10kb) Multiome | 795 | |
| chr1:46,401,942–46,402,392 | 269.3 kb | Distal (>10kb) Multiome | 511 | |
| chr1:46,406,082–46,407,120 | 273.6 kb | Distal (>10kb) Multiome | 299 |
Genomic view of the PIK3R3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.