Involved in positive regulation of canonical NF-kappaB signal transduction and positive regulation of cytokine production. Located in cytosol and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for LURAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LURAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LURAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:45,926,675–45,927,764 | 276.0 kb | Distal (>10kb) Multiome | 127 | |
| chr1:46,131,887–46,133,691 | 70.3 kb | Distal (>10kb) Multiome | 1126 | |
| chr1:46,198,117–46,198,832 | 4.9 kb | Proximal (<10kb) Multiome | 646 | |
| chr1:46,203,021–46,203,710 | 16 bp | At TSS Multiome | 394 | |
| chr1:46,246,904–46,248,623 | 44.2 kb | Distal (>10kb) Multiome | 923 | |
| chr1:46,301,645–46,303,965 | 98.6 kb | Distal (>10kb) Multiome | 1035 | |
| chr1:46,340,061–46,341,413 | 137.4 kb | Distal (>10kb) Multiome | 967 | |
| chr1:46,394,021–46,394,849 | 191.1 kb | Distal (>10kb) Multiome | 795 | |
| chr1:46,401,942–46,402,392 | 198.9 kb | Distal (>10kb) Multiome | 511 | |
| chr1:46,406,082–46,407,120 | 203.2 kb | Distal (>10kb) Multiome | 299 | |
| chr1:46,442,171–46,443,351 | 239.3 kb | Distal (>10kb) Multiome | 649 | |
| chr1:46,448,113–46,448,679 | 245.1 kb | Distal (>10kb) Multiome | 143 | |
| chr1:46,466,221–46,467,348 | 263.3 kb | Distal (>10kb) Multiome | 398 | |
| chr1:46,489,045–46,490,312 | 286.4 kb | Distal (>10kb) Multiome | 381 |
Genomic view of the LURAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.