Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPBP1L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPBP1L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPBP1L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:45,490,605–45,491,773 | 195.2 kb | Distal (>10kb) Multiome | 900 | |
| chr1:45,499,499–45,500,620 | 186.4 kb | Distal (>10kb) Multiome | 831 | |
| chr1:45,521,163–45,522,604 | 164.6 kb | Distal (>10kb) Multiome | 1155 | |
| chr1:45,550,427–45,551,304 | 135.7 kb | Distal (>10kb) Multiome | 1006 | |
| chr1:45,583,145–45,585,182 | 101.8 kb | Distal (>10kb) Multiome | 997 | |
| chr1:45,622,461–45,623,374 | 63.5 kb | Distal (>10kb) Multiome | 169 | |
| chr1:45,686,052–45,687,740 | 574 bp | At TSS Multiome | 1015 | |
| chr1:45,687,860–45,688,505 | 1.9 kb | Proximal (<10kb) Multiome | 861 | |
| chr1:45,750,186–45,751,093 | 64.2 kb | Distal (>10kb) Multiome | 961 | |
| chr1:45,802,824–45,804,412 | 117.1 kb | Distal (>10kb) Multiome | 753 | |
| chr1:45,926,675–45,927,764 | 240.8 kb | Distal (>10kb) Multiome | 127 | |
| chr1:45,929,025–45,929,719 | 242.9 kb | Distal (>10kb) Multiome | 247 |
Genomic view of the GPBP1L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.