This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for TFCP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TFCP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TFCP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:51,025,646–51,026,823 | 146.4 kb | Distal (>10kb) Multiome | 1016 | |
| chr12:51,047,625–51,048,573 | 124.7 kb | Distal (>10kb) Multiome | 892 | |
| chr12:51,082,637–51,083,972 | 89.3 kb | Distal (>10kb) Multiome | 937 | |
| chr12:51,172,263–51,173,510 | 219 bp | At TSS Multiome | 853 | |
| chr12:51,217,044–51,218,599 | 45.3 kb | Distal (>10kb) Multiome HiCAR | 687 | |
| chr12:51,238,201–51,239,451 | 66.1 kb | Distal (>10kb) Multiome | 891 | |
| chr12:51,269,409–51,270,816 | 97.1 kb | Distal (>10kb) Multiome | 750 | |
| chr12:51,320,220–51,321,248 | 148.1 kb | Distal (>10kb) Multiome | 315 | |
| chr12:51,371,336–51,371,863 | 198.8 kb | Distal (>10kb) Multiome | 431 | |
| chr12:51,390,937–51,392,088 | 218.7 kb | Distal (>10kb) Multiome | 504 | |
| chr12:51,395,449–51,396,000 | 222.9 kb | Distal (>10kb) Multiome | 274 | |
| chr12:51,424,595–51,425,524 | 252.1 kb | Distal (>10kb) Multiome | 499 |
Genomic view of the TFCP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.