TFDP1

transcription factor Dp-1 | DILC, DP1, DRTF1, Dp-1

This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]

Member of: DE-6 DE-6.8

Biological processes 37 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor binding (GO:0140297)RNA polymerase II transcription regulator complex (GO:0090575)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)chromatin (GO:0000785)chromatin (GO:0000785)cis-regulatory region sequence-specific DNA binding (GO:0000987)cytoplasm (GO:0005737)cytoplasm (GO:0005737)heterochromatin formation (GO:0031507)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of fat cell proliferation (GO:0070345)negative regulation of fat cell proliferation (GO:0070345)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein domain specific binding (GO:0019904)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of cell cycle (GO:0051726)regulation of gene expression (GO:0010468)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)transcription by RNA polymerase II (GO:0006366)transcription regulator complex (GO:0005667)

Expression (TPM)

TFs regulating TFDP1 0 TFs

Transcription factors with Perturb-seq knockdown data for TFDP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TFDP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TFDP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TFDP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr13:113,296,598–113,297,816	287.6 kb	Distal (>10kb) Multiome	1104
chr13:113,393,735–113,394,451	190.6 kb	Distal (>10kb) Multiome	576
chr13:113,397,604–113,398,329	186.8 kb	Distal (>10kb) Multiome	76
chr13:113,489,310–113,491,886	93.8 kb	Distal (>10kb) Multiome	791
chr13:113,584,313–113,585,542	91 bp	At TSS Multiome	559
chr13:113,652,944–113,653,751	68.6 kb	Distal (>10kb) Multiome	168
chr13:113,758,648–113,759,690	174.5 kb	Distal (>10kb) Multiome	428
chr13:113,860,084–113,861,280	276.0 kb	Distal (>10kb) Multiome	327

Genome Browser

Genomic view of the TFDP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.