chr2 : 101,467,277 – 101,467,819

542 bp 91 TFs 1 linked gene

This 542 bp open chromatin element is linked to RFX8 and is bound by 91 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
RFX8		6.5 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

91 transcription factors

ASCL1 2 datasets

Motif DE_12h DE_12h-ASCL1_MA1100.3 8 bp overlap

Motif DE_12h DE_12h-ASCL1_MA1631.2 9 bp overlap

Ascl2 1 dataset

Motif DE_12h DE_12h-Ascl2_MA0816.1 10 bp overlap

BCOR 2 datasets

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 377 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 233 bp overlap

BHLHE40 1 dataset

ChIP IMR-90 ENCSR957KYB.BHLHE40.IMR-90 149 bp overlap

BRD4 4 datasets

ChIP IMR-90_QUIES GSE74238.BRD4.IMR-90_QUIES 122 bp overlap

ChIP MV4-11-B_BI00894999_100nM_4h GSE101821.BRD4.MV4-11-B_BI00894999_100nM_4h 204 bp overlap

ChIP MV4-11-B_DMSO GSE101821.BRD4.MV4-11-B_DMSO 257 bp overlap

ChIP SW480 GSE110473.BRD4.SW480 232 bp overlap

CBX8 1 dataset

ChIP K-562 ENCSR000ATW.CBX8.K-562 193 bp overlap

CDKN1B 1 dataset

ChIP MDA-MB-231_p27CK-DD GSE112444.CDKN1B.MDA-MB-231_p27CK-DD 218 bp overlap

CEBPA 1 dataset

ChIP MV4-11 GSE88746.CEBPA.MV4-11 278 bp overlap

CEBPB 1 dataset

ChIP MV4-11 GSE88746.CEBPB.MV4-11 270 bp overlap

Cebpa 3 datasets

ChIP BLaER1 ENCFF031ISE 251 bp overlap

ChIP BLaER1 ENCFF262VBH 218 bp overlap

ChIP BLaER1 ENCFF460KDD 262 bp overlap

EOMES 2 datasets

Motif DE_12h DE_12h-EOMES_MA0800.2 9 bp overlap

Motif DE_24h DE_24h-EOMES_MA0800.2 9 bp overlap

EP300 1 dataset

ChIP fibroblast_senescent GSE106146.EP300.fibroblast_senescent 163 bp overlap

ESR1 1 dataset

ChIP MDA-MB-134-VI_ESTROGEN GSE51022.ESR1.MDA-MB-134-VI_ESTROGEN 269 bp overlap

FIGLA 1 dataset

Motif DE_12h DE_12h-FIGLA_MA0820.2 6 bp overlap

FLI1 1 dataset

ChIP SKNO-1 GSE23730.FLI1.SKNO-1 272 bp overlap

GATA6 4 datasets

ChIP DE_D1 S14-DE-d1-GATA6-exp1 333 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 316 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 384 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 297 bp overlap

IKZF1 1 dataset

ChIP BCR-ABL1_LAX2 GSE58825.IKZF1.BCR-ABL1_LAX2 185 bp overlap

JUN 2 datasets

ChIP DE_D1 S40-DE-d1-JUN-exp2 534 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 515 bp overlap

KAT7 1 dataset

ChIP OCI-AML-3 GSE133516.KAT7.OCI-AML-3 276 bp overlap

KMT2B-D 1 dataset

ChIP SW480 GSE115985.KMT2B-D.SW480 320 bp overlap

LIN54 2 datasets

Motif DE_12h DE_12h-LIN54_MA0619.2 7 bp overlap

Motif DE_24h DE_24h-LIN54_MA0619.2 7 bp overlap

MED1 1 dataset

ChIP HUVEC-C_siCTL GSE124892.MED1.HUVEC-C_siCTL 236 bp overlap

MLLT1_FKB 1 dataset

ChIP MV4-11 GSE82116.MLLT1_FKB.MV4-11 482 bp overlap

MYB 2 datasets

Motif DE_12h DE_12h-MYB_MA0100.4 6 bp overlap

ChIP Jurkat GSE59657.MYB.Jurkat 176 bp overlap

NANOG 5 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 334 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 137 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 402 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 281 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 263 bp overlap

NFIB 1 dataset

Motif DE_12h DE_12h-NFIB_MA1643.2 17 bp overlap

NFIC 1 dataset

Motif DE_12h DE_12h-NFIC_MA1527.2 15 bp overlap

NFIC::TLX1 1 dataset

Motif DE_12h DE_12h-NFICTLX1_MA0119.1 14 bp overlap

NFIX 1 dataset

Motif DE_12h DE_12h-NFIX_MA1528.2 14 bp overlap

NHLH1 1 dataset

Motif DE_12h DE_12h-NHLH1_MA0048.3 9 bp overlap

NR2C1 1 dataset

Motif DE_12h DE_12h-NR2C1_MA1535.2 6 bp overlap

NR2C2 1 dataset

Motif DE_12h DE_12h-NR2C2_MA1536.2 6 bp overlap

NR2F1 1 dataset

Motif DE_12h DE_12h-NR2F1_MA0017.3 12 bp overlap

NR5A1 1 dataset

Motif DE_12h DE_12h-NR5A1_MA1540.3 12 bp overlap

Nr1H2 1 dataset

Motif DE_12h DE_12h-Nr1H2_MA1996.2 6 bp overlap

Nr1H4 1 dataset

Motif DE_12h DE_12h-Nr1H4_MA1110.3 6 bp overlap

Nr1h3 1 dataset

Motif DE_12h DE_12h-Nr1h3_MA2337.1 6 bp overlap

POU5F1 2 datasets

ChIP BG03 GSE21614.POU5F1.BG03 153 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 373 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 412 bp overlap

PRDM9 1 dataset

Motif DE_12h DE_12h-PRDM9_MA1723.2 20 bp overlap

Pou5f1::Sox2 2 datasets

Motif DE_12h DE_12h-Pou5f1Sox2_MA0142.1 15 bp overlap

Motif DE_24h DE_24h-Pou5f1Sox2_MA0142.1 15 bp overlap

Pparg::Rxra 1 dataset

Motif DE_12h DE_12h-PpargRxra_MA0065.3 13 bp overlap

RAD21 1 dataset

ChIP THP-1_PMA_Dex-6h GSE103477.RAD21.THP-1_PMA_Dex-6h 161 bp overlap

RARA::RXRA 1 dataset

Motif DE_12h DE_12h-RARARXRA_MA0159.1 17 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 179 bp overlap

RELA 2 datasets

ChIP KB GSE52469.RELA.KB 103 bp overlap

ChIP SW480_16h_TNFa GSE102796.RELA.SW480_16h_TNFa 202 bp overlap

RUNX2 1 dataset

ChIP Karpas-45 GSE151819.RUNX2.Karpas-45 180 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 362 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 542 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 397 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 281 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 524 bp overlap

SMARCA4 3 datasets

ChIP Aska-SS GSE108025.SMARCA4.Aska-SS 280 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 321 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 169 bp overlap

SMARCB1 1 dataset

ChIP hiPSC GSE124903.SMARCB1.hiPSC 345 bp overlap

SMARCC1 2 datasets

ChIP hiPSC GSE124903.SMARCC1.hiPSC 215 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 371 bp overlap

SNAI1 1 dataset

Motif DE_12h DE_12h-SNAI1_MA1558.2 7 bp overlap

SNAI2 2 datasets

Motif DE_12h DE_12h-SNAI2_MA0745.3 8 bp overlap

ChIP SMS-CTR_shSNAI2 GSE137168.SNAI2.SMS-CTR_shSNAI2 185 bp overlap

SNAI3 1 dataset

Motif DE_12h DE_12h-SNAI3_MA1559.2 9 bp overlap

SOX2 3 datasets

ChIP LK2 GSE137459.SOX2.LK2 199 bp overlap

ChIP LK2_DNp63 GSE137459.SOX2.LK2_DNp63 350 bp overlap

ChIP LK2_GFP GSE137459.SOX2.LK2_GFP 409 bp overlap

SP1 1 dataset

ChIP WA01 ENCSR000BIR.SP1.WA01 133 bp overlap

SPIC 1 dataset

Motif DE_12h DE_12h-SPIC_MA0687.2 13 bp overlap

Stat5a 2 datasets

Motif DE_12h DE_12h-Stat5a_MA1624.2 9 bp overlap

Motif DE_24h DE_24h-Stat5a_MA1624.2 9 bp overlap

Stat6 1 dataset

Motif DE_12h DE_12h-Stat6_MA0520.2 10 bp overlap

T 2 datasets

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 256 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 437 bp overlap

TAF1 3 datasets

ChIP H1 ENCFF478SZO 467 bp overlap

ChIP H1 ENCFF478SZO 213 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 276 bp overlap

TBR1 2 datasets

Motif DE_12h DE_12h-TBR1_MA0802.2 9 bp overlap

Motif DE_24h DE_24h-TBR1_MA0802.2 9 bp overlap

TBX18 2 datasets

Motif DE_12h DE_12h-TBX18_MA1565.2 9 bp overlap

Motif DE_24h DE_24h-TBX18_MA1565.2 9 bp overlap

TBX19 2 datasets

Motif DE_12h DE_12h-TBX19_MA0804.2 17 bp overlap

Motif DE_24h DE_24h-TBX19_MA0804.2 17 bp overlap

TBX2 2 datasets

Motif DE_12h DE_12h-TBX2_MA0688.2 9 bp overlap

Motif DE_24h DE_24h-TBX2_MA0688.2 9 bp overlap

TBX20 2 datasets

Motif DE_12h DE_12h-TBX20_MA0689.1 11 bp overlap

Motif DE_24h DE_24h-TBX20_MA0689.1 11 bp overlap

TBX3 2 datasets

Motif DE_12h DE_12h-TBX3_MA1566.3 9 bp overlap

Motif DE_24h DE_24h-TBX3_MA1566.3 9 bp overlap

TCF12 1 dataset

Motif DE_12h DE_12h-TCF12_MA1648.2 7 bp overlap

TCF3 1 dataset

Motif DE_12h DE_12h-TCF3_MA0522.4 7 bp overlap

TCF4 1 dataset

Motif DE_12h DE_12h-TCF4_MA0830.3 8 bp overlap

TEAD4 1 dataset

ChIP H1 ENCFF778PAX 245 bp overlap

TERF2 1 dataset

ChIP LCL GSE55053.TERF2.LCL 134 bp overlap

TP53 1 dataset

ChIP SW480_shp53_16h_TNF-a GSE115985.TP53.SW480_shp53_16h_TNF-a 355 bp overlap

Tbx6 2 datasets

Motif DE_12h DE_12h-Tbx6_MA1567.3 9 bp overlap

Motif DE_24h DE_24h-Tbx6_MA1567.3 9 bp overlap

YAP1 1 dataset

ChIP WA01 GSE99202.YAP1.WA01 342 bp overlap

YY1 1 dataset

ChIP WA01 ENCSR000BKD.YY1.WA01 181 bp overlap

ZBTB7A 1 dataset

ChIP VCaP_FBS GSE123089.ZBTB7A.VCaP_FBS 136 bp overlap

ZBTB7B 1 dataset

ChIP Hep-G2 ENCSR322ULL.ZBTB7B.Hep-G2 134 bp overlap

ZEB1 1 dataset

Motif DE_12h DE_12h-ZEB1_MA0103.4 6 bp overlap

ZNF189 1 dataset

Motif DE_12h DE_12h-ZNF189_MA1725.2 9 bp overlap

ZNF263 1 dataset

ChIP K-562 ENCSR000EWN.ZNF263.K-562 220 bp overlap

ZNF331 1 dataset

Motif DE_12h DE_12h-ZNF331_MA1726.2 10 bp overlap

ZNF547 1 dataset

Motif DE_12h DE_12h-ZNF547_MA2334.1 13 bp overlap

ZNF558 1 dataset

Motif DE_12h DE_12h-ZNF558_MA2335.1 29 bp overlap

ZNF574 1 dataset

Motif DE_12h DE_12h-ZNF574_MA1982.2 14 bp overlap

ZNF737 1 dataset

ChIP Hep-G2 ENCSR127IHN.ZNF737.Hep-G2 206 bp overlap

ZNF768 1 dataset

Motif DE_12h DE_12h-ZNF768_MA1731.2 9 bp overlap

ZNF891 1 dataset

ChIP Hep-G2 ENCSR020CLV.ZNF891.Hep-G2 157 bp overlap

ZSCAN21 1 dataset

Motif DE_12h DE_12h-ZSCAN21_MA2336.1 7 bp overlap

Zic2 1 dataset

Motif DE_12h DE_12h-Zic2_MA1629.2 9 bp overlap