Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF737. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF737 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF737, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:20,285,651–20,286,726 | 279.7 kb | Distal (>10kb) Multiome | 95 | |
| chr19:20,367,718–20,368,350 | 197.7 kb | Distal (>10kb) Multiome | 103 | |
| chr19:20,371,834–20,372,343 | 193.8 kb | Distal (>10kb) Multiome | 96 | |
| chr19:20,424,664–20,425,178 | 140.8 kb | Distal (>10kb) Multiome | 133 | |
| chr19:20,565,337–20,566,048 | 22 bp | At TSS Multiome | 386 | |
| chr19:20,660,950–20,661,849 | 95.9 kb | Distal (>10kb) Multiome | 315 | |
| chr19:20,665,001–20,665,677 | 99.6 kb | Distal (>10kb) Multiome | 99 | |
| chr19:20,776,028–20,776,925 | 210.5 kb | Distal (>10kb) Multiome | 329 | |
| chr19:20,922,848–20,923,737 | 357.5 kb | Distal (>10kb) Multiome HiCAR | 286 |
Genomic view of the ZNF737 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.