chr1:27,770,363–27,771,047

chr1 : 27,770,363 – 27,771,047

684 bp 104 TFs 8 linked genes

This 684 bp open chromatin element is linked to 8 target genes and is bound by 104 transcription factors.

Linked Genes

8 genes

Gene	Expression	Dist. to TSS	Distance	Link type
STX12		2.2 kb	Proximal	Proximity
FAM76A		44.7 kb	Distal	Multiome
PPP1R8		60.2 kb	Distal	Multiome
RPA2		144.1 kb	Distal	Multiome
SMPDL3B		164.4 kb	Distal	Multiome
AHDC1		166.7 kb	Distal	Multiome
XKR8		189.3 kb	Distal	Multiome
WASF2		280.6 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

104 transcription factors

ARID1B 1 dataset

ChIP K-562 ENCSR822CCM.ARID1B.K-562 174 bp overlap

ASCL1 2 datasets

Motif DE_72h DE_72h-ASCL1_MA1100.3 8 bp overlap

Motif DE_72h DE_72h-ASCL1_MA1631.2 9 bp overlap

ChIP metastatic-neuroblastoma_SKNMM GSE100148.ATRX.metastatic-neuroblastoma_SKNMM 317 bp overlap

BCL6B 1 dataset

Motif DE_72h DE_72h-BCL6B_MA0731.1 17 bp overlap

ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 131 bp overlap

CBFA2T3 2 datasets

ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 214 bp overlap

ChIP K562 ENCFF673OEZ 272 bp overlap

CHD2 2 datasets

ChIP SK-N-SH ENCFF669KMB 315 bp overlap

ChIP SK-N-SH ENCSR274SLQ.CHD2.SK-N-SH 190 bp overlap

CTBP1 2 datasets

ChIP K-562 ENCSR201NQZ.CTBP1.K-562 258 bp overlap

ChIP K562 ENCFF403WPG 177 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF364PUR 140 bp overlap

Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap

Motif DE_72h DE_72h-DPRX_MA1480.2 9 bp overlap

Dmbx1 1 dataset

Motif DE_72h DE_72h-Dmbx1_MA0883.2 10 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 496 bp overlap

EP300 1 dataset

ChIP SK-N-SH ENCSR000EHV.EP300.SK-N-SH 520 bp overlap

ERF::FOXI1 1 dataset

Motif DE_72h DE_72h-ERFFOXI1_MA1935.2 10 bp overlap

ETV2::FOXI1 1 dataset

Motif DE_72h DE_72h-ETV2FOXI1_MA1942.2 11 bp overlap

ETV5::FOXI1 1 dataset

Motif DE_72h DE_72h-ETV5FOXI1_MA1946.2 12 bp overlap

ETV5::FOXO1 1 dataset

Motif DE_72h DE_72h-ETV5FOXO1_MA1947.2 10 bp overlap

FIGLA 1 dataset

Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap

FLI1::DRGX 1 dataset

Motif DE_72h DE_72h-FLI1DRGX_MA1949.2 14 bp overlap

FLI1::FOXI1 1 dataset

Motif DE_72h DE_72h-FLI1FOXI1_MA1950.2 11 bp overlap

FOXA2 3 datasets

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.FOXA2.BJ1-hTERT_FOXA2_GATA4_Coexp 254 bp overlap

ChIP DE DE-FOXA2-1 519 bp overlap

ChIP DE DE-FOXA2-2 630 bp overlap

FOXH1 1 dataset

Motif DE_72h DE_72h-FOXH1_MA0479.2 8 bp overlap

FOXJ3 1 dataset

ChIP SK-N-SH ENCFF124KVL 359 bp overlap

FOXO1::ELF1 1 dataset

Motif DE_72h DE_72h-FOXO1ELF1_MA1953.2 13 bp overlap

FOXO1::ELK1 1 dataset

Motif DE_72h DE_72h-FOXO1ELK1_MA1954.2 13 bp overlap

FOXO1::ELK3 1 dataset

Motif DE_72h DE_72h-FOXO1ELK3_MA1955.2 13 bp overlap

FOXO1::FLI1 1 dataset

Motif DE_72h DE_72h-FOXO1FLI1_MA1956.2 13 bp overlap

GATA1 4 datasets

ChIP CD34_ERYTH_BMP GSE29194.GATA1.CD34_ERYTH_BMP 125 bp overlap

ChIP K-562 GSE107726.GATA1.K-562 508 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 488 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 478 bp overlap

GATA1::TAL1 1 dataset

Motif DE_72h DE_72h-GATA1TAL1_MA0140.3 17 bp overlap

GATA2 10 datasets

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

ChIP K-562 ENCSR000DKA.GATA2.K-562 285 bp overlap

ChIP K562 ENCFF830LLA 488 bp overlap

ChIP SH-SY5Y ENCFF485YIB 256 bp overlap

ChIP SH-SY5Y ENCFF485YIB 405 bp overlap

ChIP SH-SY5Y ENCSR000EYB.GATA2.SH-SY5Y 547 bp overlap

ChIP SK-N-SH ENCFF764OZD 417 bp overlap

ChIP SK-N-SH ENCSR706VOO.GATA2.SK-N-SH 598 bp overlap

ChIP dermal-fibroblast_alone GSE51025.GATA2.dermal-fibroblast_alone 186 bp overlap

ChIP dermal-fibroblast_alone GSE51025.GATA2.dermal-fibroblast_alone 206 bp overlap

GATA3 8 datasets

ChIP BE2C GSE65664.GATA3.BE2C 158 bp overlap

ChIP CLB-Ga GSE90683.GATA3.CLB-Ga 526 bp overlap

ChIP Kelly GSE65664.GATA3.Kelly 523 bp overlap

ChIP MCF-7_sgScr GSE133072.GATA3.MCF-7_sgScr 179 bp overlap

ChIP SH-SY5Y ENCFF475HYF 481 bp overlap

ChIP SH-SY5Y ENCSR000EXZ.GATA3.SH-SY5Y 577 bp overlap

ChIP SH-SY5Y GSE65664.GATA3.SH-SY5Y 396 bp overlap

ChIP SK-N-BE2-C GSE94822.GATA3.SK-N-BE2-C 206 bp overlap

GATA4 9 datasets

ChIP BJ1-hTERT GSE92491.GATA4.BJ1-hTERT 302 bp overlap

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.GATA4.BJ1-hTERT_FOXA2_GATA4_Coexp 222 bp overlap

ChIP DE DE-GATA4-1 684 bp overlap

ChIP DE DE-GATA4-2 684 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP Hep-G2 GSE135714.GATA4.Hep-G2 458 bp overlap

ChIP foregut GSE117136.GATA4.foregut 616 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 643 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 562 bp overlap

GATA5 1 dataset

Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap

GATA6 15 datasets

ChIP DE DE-GATA6-1 684 bp overlap

ChIP DE DE-GATA6-2 684 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 641 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 684 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 684 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 684 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 644 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 660 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 654 bp overlap

ChIP foregut GSE117136.GATA6.foregut 634 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 422 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 542 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 559 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 593 bp overlap

GRHL2 1 dataset

Motif DE_72h DE_72h-GRHL2_MA1105.3 8 bp overlap

Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap

Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap

Gata3 1 dataset

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

HAND2 3 datasets

ChIP CLB-Ga GSE90683.HAND2.CLB-Ga 470 bp overlap

ChIP Kelly GSE94822.HAND2.Kelly 213 bp overlap

ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 471 bp overlap

IKZF1 2 datasets

ChIP K-562 ENCSR395HWC.IKZF1.K-562 296 bp overlap

ChIP K562 ENCFF348IBL 359 bp overlap

Motif DE_72h DE_72h-JUN_MA0488.2 10 bp overlap

KDM1A 3 datasets

ChIP K-562 GSE117944.KDM1A.K-562 219 bp overlap

ChIP SH-SY5Y_B3 GSE58258.KDM1A.SH-SY5Y_B3 450 bp overlap

ChIP T-47D-MTVL GSE64467.KDM1A.T-47D-MTVL 277 bp overlap

MXI1 2 datasets

ChIP SK-N-SH ENCFF746HVJ 389 bp overlap

ChIP SK-N-SH ENCFF746HVJ 491 bp overlap

MYBL2 1 dataset

ChIP K562 ENCFF299JBQ 53 bp overlap

MYCN 3 datasets

ChIP Kelly GSE94822.MYCN.Kelly 207 bp overlap

ChIP Kelly GSE94822.MYCN.Kelly 247 bp overlap

ChIP LA-N-5 GSE138295.MYCN.LA-N-5 358 bp overlap

Mecom 1 dataset

Motif DE_72h DE_72h-Mecom_MA0029.2 11 bp overlap

NFATC3 2 datasets

Motif DE_72h DE_72h-NFATC3_MA0625.3 6 bp overlap

Motif DE_72h DE_72h-NFATC3_MA0625.3 6 bp overlap

Motif DE_72h DE_72h-NFIA_MA0670.2 6 bp overlap

Motif DE_72h DE_72h-NFIC_MA0161.3 7 bp overlap

Motif DE_72h DE_72h-NFIX_MA0671.2 6 bp overlap

NHLH1 1 dataset

Motif DE_72h DE_72h-NHLH1_MA0048.3 9 bp overlap

Nfatc1 2 datasets

Motif DE_72h DE_72h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_72h DE_72h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_72h DE_72h-Nrf1_MA0506.3 12 bp overlap

Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap

Motif DE_72h DE_72h-OTX2_MA0712.3 7 bp overlap

PHOX2B 1 dataset

ChIP CLB-Ga GSE90683.PHOX2B.CLB-Ga 576 bp overlap

PITX1 1 dataset

Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap

PITX2 1 dataset

Motif DE_72h DE_72h-PITX2_MA1547.2 8 bp overlap

PITX3 2 datasets

Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap

ChIP SH-SY5Y GSE93275.PITX3.SH-SY5Y 684 bp overlap

Prdm4 1 dataset

Motif DE_72h DE_72h-Prdm4_MA1647.3 11 bp overlap

RCOR1 2 datasets

ChIP K562 ENCFF216EEJ 249 bp overlap

ChIP SK-N-SH ENCSR009TKN.RCOR1.SK-N-SH 456 bp overlap

RFX1 6 datasets

Motif DE_72h DE_72h-RFX1_MA0509.3 16 bp overlap

ChIP K-562 ENCSR968GIB.RFX1.K-562 369 bp overlap

ChIP K-562 ENCSR041AXL.RFX1.K-562 340 bp overlap

ChIP K562 ENCFF421AVO 302 bp overlap

ChIP K562 ENCFF421AVO 465 bp overlap

ChIP K562 ENCFF809XVG 259 bp overlap

Motif DE_72h DE_72h-RFX2_MA0600.3 14 bp overlap

RFX3 2 datasets

Motif DE_72h DE_72h-RFX3_MA0798.3 16 bp overlap

ChIP Hep-G2 ENCSR633OVO.RFX3.Hep-G2 146 bp overlap

Motif DE_72h DE_72h-RFX5_MA0510.3 14 bp overlap

RHOXF1 1 dataset

Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap

SCRT2 1 dataset

ChIP HEK293 ENCFF711QQB 521 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 179 bp overlap

SMAD2-3 4 datasets

ChIP HGrC1_C134W-TGF GSE138496.SMAD2-3.HGrC1_C134W-TGF 128 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 651 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 560 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 587 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 561 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 554 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 464 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 684 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 684 bp overlap

SMAD4 2 datasets

ChIP endoderm GSE29422.SMAD4.endoderm 159 bp overlap

ChIP endoderm GSE29422.SMAD4.endoderm 154 bp overlap

SMARCA4 1 dataset

ChIP NGP_ARID1A-mut2 GSE134626.SMARCA4.NGP_ARID1A-mut2 441 bp overlap

SMARCC1 2 datasets

ChIP DE_D1 S10-DE-d1-BAF155-exp1 383 bp overlap

ChIP DE_D1 S15-DE-d1-BAF155-exp1 351 bp overlap

SNAI1 1 dataset

Motif DE_72h DE_72h-SNAI1_MA1558.2 7 bp overlap

SNAI2 1 dataset

Motif DE_72h DE_72h-SNAI2_MA0745.3 8 bp overlap

SNAI3 1 dataset

Motif DE_72h DE_72h-SNAI3_MA1559.2 9 bp overlap

SPDEF 1 dataset

Motif DE_72h DE_72h-SPDEF_MA0686.2 10 bp overlap

Stat6 1 dataset

Motif DE_72h DE_72h-Stat6_MA0520.2 10 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 248 bp overlap

TAL1 7 datasets

ChIP K-562 GSE107726.TAL1.K-562 179 bp overlap

ChIP K-562 ENCSR000EHB.TAL1.K-562 209 bp overlap

ChIP K-562_dCas9-KRAB GSE132212.TAL1.K-562_dCas9-KRAB 151 bp overlap

ChIP K-562_enCRISPRi-KL GSE132212.TAL1.K-562_enCRISPRi-KL 198 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.TAL1.K-562_enCRISPRi-LK 195 bp overlap

ChIP K-562_sgGal4 GSE132212.TAL1.K-562_sgGal4 178 bp overlap

ChIP K562 ENCFF661CCK 234 bp overlap

TBX20 1 dataset

Motif DE_72h DE_72h-TBX20_MA0689.1 11 bp overlap

TCF12 1 dataset

Motif DE_72h DE_72h-TCF12_MA1648.2 7 bp overlap

Motif DE_72h DE_72h-TCF3_MA0522.4 7 bp overlap

TCF4 3 datasets

Motif DE_72h DE_72h-TCF4_MA0830.3 8 bp overlap

ChIP SH-SY5Y GSE96915.TCF4.SH-SY5Y 181 bp overlap

ChIP SK-N-SH ENCFF270OWF 437 bp overlap

TEAD1 1 dataset

Motif DE_72h DE_72h-TEAD1_MA0090.4 9 bp overlap

TEAD2 1 dataset

Motif DE_72h DE_72h-TEAD2_MA1121.2 7 bp overlap

TEAD3 1 dataset

Motif DE_72h DE_72h-TEAD3_MA0808.1 8 bp overlap

TEAD4 1 dataset

Motif DE_72h DE_72h-TEAD4_MA0809.3 8 bp overlap

TFAP2B 1 dataset

ChIP SK-N-SH ENCFF869XXQ 441 bp overlap

TRPS1 1 dataset

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap

ZEB2 3 datasets

ChIP K-562 ENCSR322CFO.ZEB2.K-562 194 bp overlap

ChIP K-562 ENCSR004GKA.ZEB2.K-562 208 bp overlap

ChIP K562 ENCFF795CMH 329 bp overlap

ZNF143 1 dataset

Motif DE_72h DE_72h-ZNF143_MA0088.2 16 bp overlap

ZNF214 1 dataset

Motif DE_72h DE_72h-ZNF214_MA1975.2 13 bp overlap

ZNF282 1 dataset

Motif DE_72h DE_72h-ZNF282_MA1154.2 15 bp overlap

ZNF331 1 dataset

Motif DE_72h DE_72h-ZNF331_MA1726.2 10 bp overlap

ZNF354A 1 dataset

Motif DE_72h DE_72h-ZNF354A_MA1978.2 20 bp overlap

ZNF416 1 dataset

Motif DE_72h DE_72h-ZNF416_MA1979.2 10 bp overlap

ZNF600 1 dataset

ChIP HEK293 ENCFF785JSX 129 bp overlap

ZNF680 1 dataset

Motif DE_72h DE_72h-ZNF680_MA1729.2 11 bp overlap

ZNF770 1 dataset

Motif DE_72h DE_72h-ZNF770_MA2099.1 8 bp overlap

Motif DE_72h DE_72h-Zfx_MA0146.3 10 bp overlap

Motif DE_72h DE_72h-Zic2_MA1629.2 9 bp overlap