Enables phosphoric diester hydrolase activity. Predicted to be involved in membrane lipid catabolic process; negative regulation of inflammatory response; and negative regulation of toll-like receptor signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMPDL3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMPDL3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMPDL3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:27,659,614–27,660,451 | 274.9 kb | Distal (>10kb) Multiome | 525 | |
| chr1:27,662,782–27,663,455 | 271.8 kb | Distal (>10kb) Multiome | 386 | |
| chr1:27,725,017–27,726,553 | 209.2 kb | Distal (>10kb) Multiome | 896 | |
| chr1:27,770,363–27,771,047 | 164.4 kb | Distal (>10kb) Multiome | 104 | |
| chr1:27,772,649–27,773,796 | 161.8 kb | Distal (>10kb) Multiome | 826 | |
| chr1:27,830,416–27,831,407 | 104.2 kb | Distal (>10kb) Multiome | 899 | |
| chr1:27,872,169–27,873,143 | 62.5 kb | Distal (>10kb) Multiome | 412 | |
| chr1:27,914,296–27,915,026 | 20.3 kb | Distal (>10kb) Multiome | 866 | |
| chr1:27,934,817–27,935,435 | 12 bp | At TSS Multiome | 308 | |
| chr1:27,959,376–27,960,547 | 24.8 kb | Distal (>10kb) Multiome | 711 | |
| chr1:28,088,113–28,088,897 | 153.7 kb | Distal (>10kb) Multiome | 827 | |
| chr1:28,104,959–28,105,483 | 170.2 kb | Distal (>10kb) Multiome | 240 | |
| chr1:28,232,593–28,233,160 | 298.0 kb | Distal (>10kb) Multiome | 666 |
Genomic view of the SMPDL3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.