AHDC1

AT-hook DNA binding motif containing 1 | DJ159A19.3, RP1-159A19.1

This gene encodes a protein containing two AT-hooks, which likely function in DNA binding. Mutations in this gene were found in individuals with Xia-Gibbs syndrome. [provided by RefSeq, Jun 2014]

Member of: DE-8

Biological processes 12 terms

DNA-binding transcription factor activity (GO:0003700)chromosome (GO:0005694)mesoderm formation (GO:0001707)mesoderm formation (GO:0001707)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)promoter-enhancer loop anchoring activity (GO:0140585)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)skin morphogenesis (GO:0043589)skin morphogenesis (GO:0043589)

Expression (TPM)

TFs regulating AHDC1 0 TFs

Transcription factors with Perturb-seq knockdown data for AHDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AHDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to AHDC1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AHDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:27,321,904–27,322,688	281.8 kb	Distal (>10kb) Multiome HiCAR	1013
chr1:27,349,161–27,350,366	254.1 kb	Distal (>10kb) Multiome	573
chr1:27,350,548–27,351,814	252.6 kb	Distal (>10kb) Multiome	387
chr1:27,357,379–27,358,028	246.3 kb	Distal (>10kb) Multiome	449
chr1:27,360,338–27,361,256	243.4 kb	Distal (>10kb) Multiome	170
chr1:27,365,152–27,367,350	237.1 kb	Distal (>10kb) Multiome	748
chr1:27,382,910–27,383,795	220.6 kb	Distal (>10kb) Multiome HiCAR	234
chr1:27,391,473–27,393,056	211.4 kb	Distal (>10kb) Multiome HiCAR	700
chr1:27,489,673–27,490,714	113.6 kb	Distal (>10kb) Multiome HiCAR	978
chr1:27,526,947–27,528,904	76.5 kb	Distal (>10kb) Multiome HiCAR	804
chr1:27,536,779–27,537,308	66.9 kb	Distal (>10kb) Multiome	160
chr1:27,556,820–27,557,711	46.6 kb	Distal (>10kb) Multiome	511
chr1:27,568,200–27,569,231	35.3 kb	Distal (>10kb) Multiome	554
chr1:27,574,996–27,576,410	27.9 kb	Distal (>10kb) Multiome	587
chr1:27,592,703–27,593,619	10.9 kb	Distal (>10kb) Multiome	100
chr1:27,600,520–27,600,893	3.0 kb	Proximal (<10kb)	76
chr1:27,602,169–27,605,005	277 bp	At TSS Multiome	726
chr1:27,606,234–27,606,825	2.3 kb	Proximal (<10kb)	309
chr1:27,606,947–27,607,757	3.5 kb	Proximal (<10kb) Multiome	620
chr1:27,608,534–27,608,880	4.6 kb	Proximal (<10kb)	428
chr1:27,614,890–27,615,294	11.2 kb	Distal (>10kb) Multiome	84
chr1:27,659,614–27,660,451	56.2 kb	Distal (>10kb) Multiome HiCAR	525
chr1:27,662,782–27,663,455	59.3 kb	Distal (>10kb) Multiome HiCAR	386
chr1:27,725,017–27,726,553	121.9 kb	Distal (>10kb) Multiome	896
chr1:27,770,363–27,771,047	166.7 kb	Distal (>10kb) Multiome	104
chr1:27,772,649–27,773,796	169.3 kb	Distal (>10kb) Multiome	826
chr1:27,830,416–27,831,407	226.9 kb	Distal (>10kb) Multiome	899
chr1:27,872,169–27,873,143	268.6 kb	Distal (>10kb) Multiome	412

Genome Browser

Genomic view of the AHDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.