This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for WASF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WASF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WASF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:27,233,894–27,235,362 | 255.6 kb | Distal (>10kb) Multiome | 807 | |
| chr1:27,321,904–27,322,688 | 167.9 kb | Distal (>10kb) Multiome | 1013 | |
| chr1:27,349,161–27,350,366 | 140.2 kb | Distal (>10kb) Multiome | 573 | |
| chr1:27,350,548–27,351,814 | 138.7 kb | Distal (>10kb) Multiome | 387 | |
| chr1:27,357,379–27,358,028 | 132.4 kb | Distal (>10kb) Multiome | 449 | |
| chr1:27,360,338–27,361,256 | 129.5 kb | Distal (>10kb) Multiome | 170 | |
| chr1:27,365,152–27,367,350 | 123.2 kb | Distal (>10kb) Multiome | 748 | |
| chr1:27,382,910–27,383,795 | 106.7 kb | Distal (>10kb) Multiome | 234 | |
| chr1:27,391,473–27,393,056 | 97.5 kb | Distal (>10kb) Multiome | 700 | |
| chr1:27,489,673–27,490,714 | 229 bp | At TSS Multiome | 978 | |
| chr1:27,526,947–27,528,904 | 37.3 kb | Distal (>10kb) Multiome | 804 | |
| chr1:27,536,779–27,537,308 | 47.0 kb | Distal (>10kb) Multiome | 160 | |
| chr1:27,556,820–27,557,711 | 67.2 kb | Distal (>10kb) Multiome | 511 | |
| chr1:27,568,200–27,569,231 | 78.6 kb | Distal (>10kb) Multiome | 554 | |
| chr1:27,574,996–27,576,410 | 86.0 kb | Distal (>10kb) Multiome | 587 | |
| chr1:27,592,703–27,593,619 | 103.0 kb | Distal (>10kb) Multiome | 100 | |
| chr1:27,602,169–27,605,005 | 114.2 kb | Distal (>10kb) Multiome | 726 | |
| chr1:27,606,947–27,607,757 | 117.4 kb | Distal (>10kb) Multiome | 620 | |
| chr1:27,614,890–27,615,294 | 125.1 kb | Distal (>10kb) Multiome | 84 | |
| chr1:27,659,614–27,660,451 | 170.1 kb | Distal (>10kb) Multiome | 525 | |
| chr1:27,662,782–27,663,455 | 173.2 kb | Distal (>10kb) Multiome | 386 | |
| chr1:27,725,017–27,726,553 | 235.8 kb | Distal (>10kb) Multiome | 896 | |
| chr1:27,770,363–27,771,047 | 280.6 kb | Distal (>10kb) Multiome | 104 | |
| chr1:27,772,649–27,773,796 | 283.1 kb | Distal (>10kb) Multiome | 826 |
Genomic view of the WASF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.