XKR8
XK related 8 | FLJ10307

Enables phospholipid scramblase activity. Involved in engulfment of apoptotic cell; phosphatidylserine exposure on apoptotic cell surface; and positive regulation of myoblast differentiation. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 DE-1.3
Biological processes 23 terms
apoptotic process involved in development (GO:1902742)engulfment of apoptotic cell (GO:0043652)engulfment of apoptotic cell (GO:0043652)engulfment of apoptotic cell (GO:0043652)membrane (GO:0016020)neutrophil clearance (GO:0097350)neutrophil clearance (GO:0097350)perinuclear region of cytoplasm (GO:0048471)phosphatidylserine exposure on apoptotic cell surface (GO:0070782)phosphatidylserine exposure on apoptotic cell surface (GO:0070782)phosphatidylserine exposure on apoptotic cell surface (GO:0070782)phosphatidylserine exposure on apoptotic cell surface (GO:0070782)phospholipid scramblase activity (GO:0017128)phospholipid scramblase activity (GO:0017128)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of myoblast differentiation (GO:0045663)positive regulation of myoblast differentiation (GO:0045663)synapse pruning (GO:0098883)synapse pruning (GO:0098883)
Expression (TPM)
XKR8 — as a Regulated Gene

TFs regulating XKR8 0 TFs

Transcription factors with Perturb-seq knockdown data for XKR8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XKR8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to XKR8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XKR8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:27,659,614–27,660,451 299.9 kb Distal (>10kb) Multiome 525
chr1:27,662,782–27,663,455 296.7 kb Distal (>10kb) Multiome 386
chr1:27,725,017–27,726,553 234.1 kb Distal (>10kb) Multiome 896
chr1:27,770,363–27,771,047 189.3 kb Distal (>10kb) Multiome 104
chr1:27,772,649–27,773,796 186.8 kb Distal (>10kb) Multiome 826
chr1:27,830,416–27,831,407 129.2 kb Distal (>10kb) Multiome 899
chr1:27,872,169–27,873,143 87.5 kb Distal (>10kb) Multiome 412
chr1:27,914,296–27,915,026 45.3 kb Distal (>10kb) Multiome 866
chr1:27,934,817–27,935,435 25.0 kb Distal (>10kb) Multiome 308
chr1:27,959,376–27,960,547 112 bp At TSS Multiome 711
chr1:28,088,113–28,088,897 128.7 kb Distal (>10kb) Multiome 827
chr1:28,104,959–28,105,483 145.3 kb Distal (>10kb) Multiome 240
chr1:28,232,593–28,233,160 273.0 kb Distal (>10kb) Multiome 666
chr1:28,235,692–28,236,588 276.1 kb Distal (>10kb) Multiome 862
chr1:28,247,126–28,247,685 287.3 kb Distal (>10kb) Multiome 544
chr1:28,258,840–28,260,822 299.4 kb Distal (>10kb) Multiome 910

Genome Browser

Genomic view of the XKR8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:27,649,614 – 28,270,822
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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