STX12
syntaxin 12 | STX13, STX14

Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in autophagosome assembly; cholesterol efflux; and protein stabilization. Located in several cellular components, including BLOC-1 complex; phagocytic vesicle; and phagophore assembly site. Part of SNARE complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4 Developmental clusters: GC7
Biological processes 34 terms
BLOC-1 complex (GO:0031083)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)SNAP receptor activity (GO:0005484)SNAP receptor activity (GO:0005484)SNARE binding (GO:0000149)SNARE complex (GO:0031201)SNARE complex (GO:0031201)autophagosome assembly (GO:0000045)autophagosome assembly (GO:0000045)cholesterol efflux (GO:0033344)cytoplasmic vesicle (GO:0031410)early endosome membrane (GO:0031901)endocytic recycling (GO:0032456)endomembrane system (GO:0012505)endomembrane system (GO:0012505)endosome membrane (GO:0010008)intracellular protein transport (GO:0006886)intracellular protein transport (GO:0006886)membrane (GO:0016020)membrane raft (GO:0045121)phagocytic vesicle (GO:0045335)phagophore assembly site (GO:0000407)postsynaptic recycling endosome (GO:0098837)protein binding (GO:0005515)protein stabilization (GO:0050821)recycling endosome (GO:0055037)recycling endosome membrane (GO:0055038)synaptic vesicle (GO:0008021)synaptic vesicle membrane (GO:0030672)vesicle (GO:0031982)vesicle docking (GO:0048278)vesicle fusion (GO:0006906)vesicle-mediated transport (GO:0016192)
Expression (TPM)
STX12 — as a Regulated Gene

TFs regulating STX12 0 TFs

Transcription factors with Perturb-seq knockdown data for STX12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STX12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to STX12

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STX12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:27,489,673–27,490,714 283.0 kb Distal (>10kb) Multiome 978
chr1:27,526,947–27,528,904 245.9 kb Distal (>10kb) Multiome 804
chr1:27,536,779–27,537,308 236.2 kb Distal (>10kb) Multiome 160
chr1:27,556,820–27,557,711 216.0 kb Distal (>10kb) Multiome 511
chr1:27,568,200–27,569,231 204.6 kb Distal (>10kb) Multiome 554
chr1:27,574,996–27,576,410 197.2 kb Distal (>10kb) Multiome 587
chr1:27,592,703–27,593,619 180.2 kb Distal (>10kb) Multiome 100
chr1:27,602,169–27,605,005 169.1 kb Distal (>10kb) Multiome 726
chr1:27,606,947–27,607,757 165.8 kb Distal (>10kb) Multiome 620
chr1:27,614,890–27,615,294 158.1 kb Distal (>10kb) Multiome 84
chr1:27,659,614–27,660,451 113.2 kb Distal (>10kb) Multiome 525
chr1:27,662,782–27,663,455 110.0 kb Distal (>10kb) Multiome 386
chr1:27,725,017–27,726,553 47.4 kb Distal (>10kb) Multiome 896
chr1:27,770,363–27,771,047 2.6 kb Proximal (<10kb) Multiome 104
chr1:27,772,649–27,773,796 58 bp At TSS Multiome 826
chr1:27,830,416–27,831,407 57.5 kb Distal (>10kb) Multiome 899
chr1:27,872,169–27,873,143 99.3 kb Distal (>10kb) Multiome 412
chr1:27,914,296–27,915,026 141.4 kb Distal (>10kb) Multiome 866
chr1:27,934,817–27,935,435 161.8 kb Distal (>10kb) Multiome 308
chr1:27,959,376–27,960,547 186.6 kb Distal (>10kb) Multiome 711

Genome Browser

Genomic view of the STX12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:27,479,673 – 27,970,547
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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