PPP1R8

protein phosphatase 1 regulatory subunit 8 | ARD1, NIPP-1, NIPP1, PRO2047, ard-1

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]

Member of: DE-5

Biological processes 18 terms

RNA binding (GO:0003723)RNA catabolic process (GO:0006401)RNA endonuclease activity (GO:0004521)cytoplasm (GO:0005737)mRNA binding (GO:0003729)molecular function inhibitor activity (GO:0140678)nuclear speck (GO:0016607)nuclear speck (GO:0016607)nuclear speck (GO:0016607)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein phosphatase regulator activity (GO:0019888)protein serine/threonine phosphatase inhibitor activity (GO:0004865)protein serine/threonine phosphatase inhibitor activity (GO:0004865)ribonuclease E activity (GO:0008995)

Expression (TPM)

TFs regulating PPP1R8 0 TFs

Transcription factors with Perturb-seq knockdown data for PPP1R8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PPP1R8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:27,536,779–27,537,308	293.8 kb	Distal (>10kb) Multiome	160
chr1:27,556,820–27,557,711	273.5 kb	Distal (>10kb) Multiome	511
chr1:27,568,200–27,569,231	262.2 kb	Distal (>10kb) Multiome	554
chr1:27,574,996–27,576,410	254.8 kb	Distal (>10kb) Multiome	587
chr1:27,592,703–27,593,619	237.8 kb	Distal (>10kb) Multiome	100
chr1:27,602,169–27,605,005	226.6 kb	Distal (>10kb) Multiome	726
chr1:27,606,947–27,607,757	223.4 kb	Distal (>10kb) Multiome	620
chr1:27,614,890–27,615,294	215.7 kb	Distal (>10kb) Multiome	84
chr1:27,659,614–27,660,451	170.7 kb	Distal (>10kb) Multiome	525
chr1:27,662,782–27,663,455	167.6 kb	Distal (>10kb) Multiome	386
chr1:27,725,017–27,726,553	105.0 kb	Distal (>10kb) Multiome	896
chr1:27,770,363–27,771,047	60.2 kb	Distal (>10kb) Multiome	104
chr1:27,772,649–27,773,796	57.6 kb	Distal (>10kb) Multiome	826
chr1:27,830,416–27,831,407	25 bp	At TSS Multiome	899
chr1:27,872,169–27,873,143	41.7 kb	Distal (>10kb) Multiome	412
chr1:27,914,296–27,915,026	83.9 kb	Distal (>10kb) Multiome	866
chr1:27,934,817–27,935,435	104.2 kb	Distal (>10kb) Multiome	308
chr1:27,959,376–27,960,547	129.0 kb	Distal (>10kb) Multiome	711
chr1:28,088,113–28,088,897	257.9 kb	Distal (>10kb) Multiome	827
chr1:28,104,959–28,105,483	274.5 kb	Distal (>10kb) Multiome	240

Genome Browser

Genomic view of the PPP1R8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.