chr8:17,492,952–17,493,458

chr8 : 17,492,952 – 17,493,458

506 bp 84 TFs 6 linked genes

This 506 bp open chromatin element is linked to 6 target genes and is bound by 84 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
SLC7A2		3.6 kb	Proximal	Proximity
MTMR7		80.0 kb	Distal	Multiome
PDGFRL		83.9 kb	Distal	Multiome
VPS37A		246.4 kb	Distal	Multiome
CNOT7		246.5 kb	Distal	Multiome
ENSG00000289145		267.3 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

84 transcription factors

CBX8 2 datasets

ChIP A-549 ENCSR616MOB.CBX8.A-549 479 bp overlap

ChIP A549 ENCFF656LMW 283 bp overlap

DPRX 4 datasets

Motif DE_36h DE_36h-DPRX_MA1480.2 9 bp overlap

Motif DE_48h DE_48h-DPRX_MA1480.2 9 bp overlap

Motif DE_60h DE_60h-DPRX_MA1480.2 9 bp overlap

Motif DE_72h DE_72h-DPRX_MA1480.2 9 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 267 bp overlap

ESRRA 1 dataset

Motif DE_60h DE_60h-ESRRA_MA0592.4 9 bp overlap

ESRRB 1 dataset

Motif DE_60h DE_60h-ESRRB_MA0141.4 10 bp overlap

ETV5::DRGX 2 datasets

Motif DE_60h DE_60h-ETV5DRGX_MA1944.2 12 bp overlap

Motif DE_72h DE_72h-ETV5DRGX_MA1944.2 12 bp overlap

Esrrg 1 dataset

Motif DE_60h DE_60h-Esrrg_MA0643.2 9 bp overlap

FEZF1 3 datasets

ChIP HEK293 ENCFF528YED 416 bp overlap

ChIP HEK293 ENCSR827NWO.FEZF1.HEK293 220 bp overlap

ChIP HEK293 GSE76494.FEZF1.HEK293 148 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 437 bp overlap

ChIP DE DE-FOXA2-2 483 bp overlap

FOXB1 2 datasets

Motif DE_60h DE_60h-FOXB1_MA0845.1 11 bp overlap

Motif DE_72h DE_72h-FOXB1_MA0845.1 11 bp overlap

FOXD2 1 dataset

Motif DE_60h DE_60h-FOXD2_MA0847.4 11 bp overlap

FOXN3 2 datasets

Motif DE_60h DE_60h-FOXN3_MA1489.1 8 bp overlap

Motif DE_72h DE_72h-FOXN3_MA1489.1 8 bp overlap

Foxl2 2 datasets

Motif DE_60h DE_60h-Foxl2_MA1607.2 10 bp overlap

Motif DE_72h DE_72h-Foxl2_MA1607.2 10 bp overlap

GATA1::TAL1 2 datasets

Motif DE_60h DE_60h-GATA1TAL1_MA0140.3 17 bp overlap

Motif DE_72h DE_72h-GATA1TAL1_MA0140.3 17 bp overlap

GATA2 2 datasets

Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

GATA4 8 datasets

ChIP DE DE-GATA4-1 506 bp overlap

ChIP DE DE-GATA4-2 506 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP Hep-G2 GSE135714.GATA4.Hep-G2 282 bp overlap

ChIP foregut GSE117136.GATA4.foregut 469 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 506 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 349 bp overlap

GATA5 2 datasets

Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap

Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap

GATA6 15 datasets

ChIP DE DE-GATA6-1 449 bp overlap

ChIP DE DE-GATA6-2 506 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 506 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 499 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 506 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 506 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 506 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 506 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 446 bp overlap

ChIP foregut GSE117136.GATA6.foregut 478 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 450 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 451 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 312 bp overlap

GRHL2 1 dataset

Motif DE_60h DE_60h-GRHL2_MA1105.3 8 bp overlap

Gata3 2 datasets

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

HDAC1 1 dataset

ChIP HepG2 ENCFF304IEJ 111 bp overlap

IKZF1 2 datasets

Motif DE_60h DE_60h-IKZF1_MA1508.2 8 bp overlap

Motif DE_72h DE_72h-IKZF1_MA1508.2 8 bp overlap

INO80 1 dataset

ChIP Huh-7 GSE97411.INO80.Huh-7 359 bp overlap

INSM1 2 datasets

Motif DE_60h DE_60h-INSM1_MA0155.1 12 bp overlap

Motif DE_72h DE_72h-INSM1_MA0155.1 12 bp overlap

KLF10 2 datasets

Motif DE_60h DE_60h-KLF10_MA1511.2 9 bp overlap

Motif DE_72h DE_72h-KLF10_MA1511.2 9 bp overlap

KLF12 2 datasets

Motif DE_60h DE_60h-KLF12_MA0742.2 9 bp overlap

Motif DE_72h DE_72h-KLF12_MA0742.2 9 bp overlap

KLF15 2 datasets

Motif DE_60h DE_60h-KLF15_MA1513.2 8 bp overlap

Motif DE_72h DE_72h-KLF15_MA1513.2 8 bp overlap

KLF17 2 datasets

Motif DE_60h DE_60h-KLF17_MA1514.2 14 bp overlap

Motif DE_72h DE_72h-KLF17_MA1514.2 14 bp overlap

KLF4 3 datasets

Motif DE_36h DE_36h-KLF4_MA0039.5 8 bp overlap

Motif DE_60h DE_60h-KLF4_MA0039.5 8 bp overlap

Motif DE_72h DE_72h-KLF4_MA0039.5 8 bp overlap

ChIP HEK293 GSE88976.KLF5.HEK293 169 bp overlap

KMT2A 1 dataset

ChIP HEK293T_N-term_C49 GSE90762.KMT2A.HEK293T_N-term_C49 364 bp overlap

MEIS1 1 dataset

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

MYNN 3 datasets

ChIP HEK293 ENCFF897QZG 346 bp overlap

ChIP HEK293 ENCSR707BNG.MYNN.HEK293 292 bp overlap

ChIP HEK293 GSE76494.MYNN.HEK293 166 bp overlap

NANOG 1 dataset

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 155 bp overlap

NEUROD1 3 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 484 bp overlap

ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 415 bp overlap

ChIP D341-Med_shNEUROD1-1154 GSE92582.NEUROD1.D341-Med_shNEUROD1-1154 156 bp overlap

NFATC3 2 datasets

Motif DE_60h DE_60h-NFATC3_MA0625.3 6 bp overlap

Motif DE_72h DE_72h-NFATC3_MA0625.3 6 bp overlap

NFYB 4 datasets

Motif DE_36h DE_36h-NFYB_MA0502.3 9 bp overlap

Motif DE_48h DE_48h-NFYB_MA0502.3 9 bp overlap

Motif DE_60h DE_60h-NFYB_MA0502.3 9 bp overlap

Motif DE_72h DE_72h-NFYB_MA0502.3 9 bp overlap

NR4A1 2 datasets

Motif DE_60h DE_60h-NR4A1_MA1112.3 8 bp overlap

Motif DE_72h DE_72h-NR4A1_MA1112.3 8 bp overlap

NR5A1 4 datasets

Motif DE_36h DE_36h-NR5A1_MA1540.3 12 bp overlap

Motif DE_48h DE_48h-NR5A1_MA1540.3 12 bp overlap

Motif DE_60h DE_60h-NR5A1_MA1540.3 12 bp overlap

Motif DE_72h DE_72h-NR5A1_MA1540.3 12 bp overlap

Nfat5 2 datasets

Motif DE_60h DE_60h-Nfat5_MA0606.3 8 bp overlap

Motif DE_72h DE_72h-Nfat5_MA0606.3 8 bp overlap

Nfatc1 2 datasets

Motif DE_60h DE_60h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_72h DE_72h-Nfatc1_MA0624.3 6 bp overlap

Nr2e1 2 datasets

Motif DE_60h DE_60h-Nr2e1_MA0676.1 9 bp overlap

Motif DE_72h DE_72h-Nr2e1_MA0676.1 9 bp overlap

Nr5A2 1 dataset

Motif DE_60h DE_60h-Nr5A2_MA0505.3 9 bp overlap

ChIP pancreatic-progenitor GSE117136.PDX1.pancreatic-progenitor 313 bp overlap

PHF19 1 dataset

ChIP DU145_CTR GSE135623.PHF19.DU145_CTR 337 bp overlap

PHIP 3 datasets

ChIP HCT-116_ab833 GSE101646.PHIP.HCT-116_ab833 235 bp overlap

ChIP HCT-116_ab833 GSE101646.PHIP.HCT-116_ab833 122 bp overlap

ChIP HEK293_ab833 GSE101646.PHIP.HEK293_ab833 324 bp overlap

POU5F1 4 datasets

Motif DE_36h DE_36h-POU5F1_MA1115.2 7 bp overlap

Motif DE_48h DE_48h-POU5F1_MA1115.2 7 bp overlap

Motif DE_60h DE_60h-POU5F1_MA1115.2 7 bp overlap

Motif DE_72h DE_72h-POU5F1_MA1115.2 7 bp overlap

PRDM6 2 datasets

ChIP HEK293 ENCFF283AJL 251 bp overlap

ChIP HEK293 ENCSR892QHR.PRDM6.HEK293 378 bp overlap

PRDM9 4 datasets

Motif DE_36h DE_36h-PRDM9_MA1723.2 20 bp overlap

Motif DE_48h DE_48h-PRDM9_MA1723.2 20 bp overlap

Motif DE_60h DE_60h-PRDM9_MA1723.2 20 bp overlap

Motif DE_72h DE_72h-PRDM9_MA1723.2 20 bp overlap

Prdm14 2 datasets

Motif DE_60h DE_60h-Prdm14_MA1998.2 8 bp overlap

Motif DE_72h DE_72h-Prdm14_MA1998.2 8 bp overlap

Prdm15 4 datasets

Motif DE_36h DE_36h-Prdm15_MA1616.2 11 bp overlap

Motif DE_48h DE_48h-Prdm15_MA1616.2 11 bp overlap

Motif DE_60h DE_60h-Prdm15_MA1616.2 11 bp overlap

Motif DE_72h DE_72h-Prdm15_MA1616.2 11 bp overlap

ChIP A-549 ENCSR798EGJ.RNF2.A-549 506 bp overlap

SCRT1 1 dataset

ChIP HEK293 ENCSR605MGM.SCRT1.HEK293 350 bp overlap

SCRT2 2 datasets

Motif DE_60h DE_60h-SCRT2_MA0744.3 10 bp overlap

ChIP HEK293 ENCFF711QQB 289 bp overlap

ChIP LTAD_EtOH GSE94577.SFPQ.LTAD_EtOH 220 bp overlap

SIX1 2 datasets

Motif DE_60h DE_60h-SIX1_MA1118.2 9 bp overlap

Motif DE_72h DE_72h-SIX1_MA1118.2 9 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 149 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 477 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 278 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 400 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 398 bp overlap

SMAD3 1 dataset

ChIP Hep-G2 ENCSR005GZH.SMAD3.Hep-G2 148 bp overlap

SMARCA4 2 datasets

ChIP HS-SY-2_HA-tagged GSE108926.SMARCA4.HS-SY-2_HA-tagged 506 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 369 bp overlap

SMARCC1 1 dataset

ChIP DE_D1 S15-DE-d1-BAF155-exp1 295 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 257 bp overlap

STAT3 2 datasets

Motif DE_60h DE_60h-STAT3_MA0144.3 9 bp overlap

Motif DE_72h DE_72h-STAT3_MA0144.3 9 bp overlap

SUZ12 1 dataset

ChIP Aska-SS GSE108025.SUZ12.Aska-SS 320 bp overlap

TRPS1 2 datasets

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

ChIP Hep-G2_RBM25-KD GSE120104.YY1.Hep-G2_RBM25-KD 184 bp overlap

ZBED4 2 datasets

Motif DE_60h DE_60h-ZBED4_MA2328.1 10 bp overlap

Motif DE_72h DE_72h-ZBED4_MA2328.1 10 bp overlap

ZBTB26 2 datasets

ChIP HEK293 ENCFF752POA 281 bp overlap

ChIP HEK293 ENCFF752TCU 57 bp overlap

ZBTB8A 1 dataset

ChIP HEK293 ENCSR481FEC.ZBTB8A.HEK293 250 bp overlap

ZNF22 1 dataset

ChIP HEK293 GSE76494.ZNF22.HEK293 151 bp overlap

ZNF335 2 datasets

ChIP HEK293 ENCFF784SLD 88 bp overlap

ChIP HEK293 ENCSR328SUD.ZNF335.HEK293 172 bp overlap

ZNF341 3 datasets

ChIP HEK293 ENCFF944VMC 334 bp overlap

ChIP HEK293 ENCSR185FOY.ZNF341.HEK293 292 bp overlap

ChIP HEK293 GSE76494.ZNF341.HEK293 180 bp overlap

ZNF354A 4 datasets

Motif DE_36h DE_36h-ZNF354A_MA1978.2 20 bp overlap

Motif DE_48h DE_48h-ZNF354A_MA1978.2 20 bp overlap

Motif DE_60h DE_60h-ZNF354A_MA1978.2 20 bp overlap

Motif DE_72h DE_72h-ZNF354A_MA1978.2 20 bp overlap

ZNF362 2 datasets

ChIP HEK293 ENCSR715QNO.ZNF362.HEK293 236 bp overlap

ChIP HEK293 ENCSR715QNO.ZNF362.HEK293 147 bp overlap

ZNF384 2 datasets

ChIP HEK293T ENCFF019DZX 239 bp overlap

ChIP HEK293T ENCSR882ICT.ZNF384.HEK293T 162 bp overlap

ZNF605 1 dataset

ChIP HEK293T GSE78099.ZNF605.HEK293T 321 bp overlap

ZNF708 2 datasets

Motif DE_60h DE_60h-ZNF708_MA1730.2 9 bp overlap

Motif DE_72h DE_72h-ZNF708_MA1730.2 9 bp overlap

ZNF766 2 datasets

Motif DE_60h DE_60h-ZNF766_MA2098.1 9 bp overlap

Motif DE_72h DE_72h-ZNF766_MA2098.1 9 bp overlap

ZNF85 2 datasets

Motif DE_60h DE_60h-ZNF85_MA1720.2 12 bp overlap

Motif DE_72h DE_72h-ZNF85_MA1720.2 12 bp overlap

ChIP HEK293 ENCSR559IOZ.ZXDB.HEK293 255 bp overlap

Zic1::Zic2 2 datasets

Motif DE_60h DE_60h-Zic1Zic2_MA1628.2 7 bp overlap

Motif DE_72h DE_72h-Zic1Zic2_MA1628.2 7 bp overlap

Zic2 2 datasets

Motif DE_60h DE_60h-Zic2_MA1629.2 9 bp overlap

Motif DE_72h DE_72h-Zic2_MA1629.2 9 bp overlap

Zic3 2 datasets

Motif DE_60h DE_60h-Zic3_MA0697.3 7 bp overlap

Motif DE_72h DE_72h-Zic3_MA0697.3 7 bp overlap