The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for CNOT7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNOT7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNOT7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:17,000,704–17,002,791 | 245.1 kb | Distal (>10kb) Multiome | 476 | |
| chr8:17,026,598–17,028,107 | 219.7 kb | Distal (>10kb) Multiome | 783 | |
| chr8:17,155,620–17,157,352 | 90.7 kb | Distal (>10kb) Multiome | 722 | |
| chr8:17,185,410–17,186,108 | 61.1 kb | Distal (>10kb) Multiome | 170 | |
| chr8:17,246,012–17,247,955 | 229 bp | At TSS Multiome | 946 | |
| chr8:17,254,188–17,254,541 | 7.7 kb | Proximal (<10kb) | 88 | |
| chr8:17,412,609–17,414,138 | 166.6 kb | Distal (>10kb) Multiome | 371 | |
| chr8:17,492,952–17,493,458 | 246.5 kb | Distal (>10kb) Multiome | 84 | |
| chr8:17,496,689–17,497,811 | 250.2 kb | Distal (>10kb) Multiome | 582 |
Genomic view of the CNOT7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.