This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for VPS37A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VPS37A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VPS37A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:17,000,704–17,002,791 | 245.2 kb | Distal (>10kb) Multiome | 476 | |
| chr8:17,026,598–17,028,107 | 219.8 kb | Distal (>10kb) Multiome | 783 | |
| chr8:17,155,620–17,157,352 | 90.8 kb | Distal (>10kb) Multiome | 722 | |
| chr8:17,185,410–17,186,108 | 61.2 kb | Distal (>10kb) Multiome | 170 | |
| chr8:17,246,012–17,247,955 | 329 bp | At TSS Multiome | 946 | |
| chr8:17,254,188–17,254,541 | 7.2 kb | Proximal (<10kb) | 88 | |
| chr8:17,412,609–17,414,138 | 166.5 kb | Distal (>10kb) Multiome | 371 | |
| chr8:17,492,952–17,493,458 | 246.4 kb | Distal (>10kb) Multiome | 84 | |
| chr8:17,496,689–17,497,811 | 250.1 kb | Distal (>10kb) Multiome | 582 |
Genomic view of the VPS37A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.