Transcription factors with Perturb-seq knockdown data for ENSG00000289145. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289145 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289145, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:17,000,704–17,002,791 | 224.3 kb | Distal (>10kb) Multiome | 476 | |
| chr8:17,026,598–17,028,107 | 198.8 kb | Distal (>10kb) Multiome | 783 | |
| chr8:17,155,620–17,157,352 | 69.9 kb | Distal (>10kb) Multiome | 722 | |
| chr8:17,185,410–17,186,108 | 40.3 kb | Distal (>10kb) Multiome | 170 | |
| chr8:17,246,012–17,247,955 | 20.6 kb | Distal (>10kb) Multiome | 946 | |
| chr8:17,412,609–17,414,138 | 187.4 kb | Distal (>10kb) Multiome | 371 | |
| chr8:17,492,952–17,493,458 | 267.3 kb | Distal (>10kb) Multiome | 84 | |
| chr8:17,496,689–17,497,811 | 271.0 kb | Distal (>10kb) Multiome | 582 |
Genomic view of the ENSG00000289145 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.