This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded protein is characterized by four distinct domains that are conserved among all members of the myotubularin family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for MTMR7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTMR7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTMR7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:17,155,620–17,157,352 | 257.2 kb | Distal (>10kb) Multiome | 722 | |
| chr8:17,185,410–17,186,108 | 227.6 kb | Distal (>10kb) Multiome | 170 | |
| chr8:17,246,012–17,247,955 | 166.7 kb | Distal (>10kb) Multiome | 946 | |
| chr8:17,412,609–17,414,138 | 104 bp | At TSS Multiome | 371 | |
| chr8:17,492,952–17,493,458 | 80.0 kb | Distal (>10kb) Multiome | 84 | |
| chr8:17,496,689–17,497,811 | 83.7 kb | Distal (>10kb) Multiome | 582 | |
| chr8:17,576,233–17,578,047 | 164.2 kb | Distal (>10kb) Multiome | 651 | |
| chr8:17,608,058–17,609,221 | 195.5 kb | Distal (>10kb) Multiome | 337 |
Genomic view of the MTMR7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.