Enables DNA binding activity; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within double-strand break repair via homologous recombination. Located in chromatin; nuclear matrix; and paraspeckles. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SFPQ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFPQ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFPQ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:34,929,050–34,930,777 | 263.6 kb | Distal (>10kb) Multiome | 401 | |
| chr1:34,984,883–34,985,660 | 207.8 kb | Distal (>10kb) Multiome | 682 | |
| chr1:35,031,470–35,032,157 | 161.3 kb | Distal (>10kb) Multiome | 762 | |
| chr1:35,079,136–35,079,827 | 113.8 kb | Distal (>10kb) Multiome | 764 | |
| chr1:35,191,872–35,193,675 | 1.1 kb | Proximal (<10kb) Multiome | 986 | |
| chr1:35,202,184–35,202,410 | 9.0 kb | Proximal (<10kb) | 366 | |
| chr1:35,268,326–35,269,324 | 75.7 kb | Distal (>10kb) Multiome | 761 | |
| chr1:35,390,099–35,390,702 | 197.3 kb | Distal (>10kb) Multiome | 47 | |
| chr1:35,390,839–35,391,860 | 198.1 kb | Distal (>10kb) Multiome | 219 | |
| chr1:35,533,667–35,534,085 | 340.8 kb | Distal (>10kb) Multiome HiCAR | 64 | |
| chr1:35,556,848–35,558,023 | 364.5 kb | Distal (>10kb) Multiome HiCAR | 894 |
Genomic view of the SFPQ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.