This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PDGFRL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDGFRL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDGFRL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:17,412,609–17,414,138 | 163.8 kb | Distal (>10kb) Multiome | 371 | |
| chr8:17,492,952–17,493,458 | 83.9 kb | Distal (>10kb) Multiome | 84 | |
| chr8:17,496,689–17,497,811 | 80.2 kb | Distal (>10kb) Multiome | 582 | |
| chr8:17,576,233–17,578,047 | 323 bp | At TSS Multiome | 651 | |
| chr8:17,608,058–17,609,221 | 31.6 kb | Distal (>10kb) Multiome | 337 | |
| chr8:17,748,883–17,749,493 | 172.1 kb | Distal (>10kb) Multiome | 49 | |
| chr8:17,800,593–17,801,971 | 224.1 kb | Distal (>10kb) Multiome | 778 | |
| chr8:17,912,201–17,912,908 | 335.4 kb | Distal (>10kb) Multiome HiCAR | 360 |
Genomic view of the PDGFRL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.