The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for SLC7A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC7A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC7A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:17,246,012–17,247,955 | 250.5 kb | Distal (>10kb) Multiome | 946 | |
| chr8:17,412,609–17,414,138 | 83.7 kb | Distal (>10kb) Multiome | 371 | |
| chr8:17,490,792–17,491,026 | 6.1 kb | Proximal (<10kb) | 23 | |
| chr8:17,492,952–17,493,458 | 3.8 kb | Proximal (<10kb) Multiome | 84 | |
| chr8:17,493,655–17,493,845 | 3.2 kb | Proximal (<10kb) | 32 | |
| chr8:17,496,136–17,496,622 | 464 bp | At TSS | 365 | |
| chr8:17,496,689–17,497,811 | 75 bp | At TSS Multiome | 582 | |
| chr8:17,502,125–17,502,356 | 5.0 kb | Proximal (<10kb) | 46 | |
| chr8:17,576,233–17,578,047 | 80.5 kb | Distal (>10kb) Multiome | 651 | |
| chr8:17,608,058–17,609,221 | 111.7 kb | Distal (>10kb) Multiome | 337 | |
| chr8:17,748,883–17,749,493 | 252.2 kb | Distal (>10kb) Multiome | 49 |
Genomic view of the SLC7A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.