chr6 : 53,495,283 – 53,496,107

824 bp 93 TFs 4 linked genes

This 824 bp open chromatin element is linked to 4 target genes and is bound by 93 transcription factors.

Linked Genes

4 genes

Gene	Dist. to TSS	Distance	Link type
GCLC	49.3 kb	Distal	Multiome
ELOVL5	146.8 kb	Distal	Multiome
ENSG00000227885	298.0 kb	Distal	Multiome
LRRC1	299.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

93 transcription factors

ARNTL 1 dataset

ChIP U2OS_trough_DMSO GSE85096.ARNTL.U2OS_trough_DMSO 138 bp overlap

Ascl2 1 dataset

Motif DE_60h DE_60h-Ascl2_MA0816.1 10 bp overlap

Atoh1 1 dataset

Motif DE_60h DE_60h-Atoh1_MA1467.3 7 bp overlap

BHLHE22 1 dataset

Motif DE_60h DE_60h-BHLHE22_MA1635.2 6 bp overlap

BHLHE40 1 dataset

ChIP IMR-90 ENCSR957KYB.BHLHE40.IMR-90 176 bp overlap

CEBPB 1 dataset

ChIP IMR-90 ENCFF468UGY 251 bp overlap

CHD7 1 dataset

ChIP WA01 ENCSR000AVA.CHD7.WA01 141 bp overlap

CREB1 1 dataset

ChIP A-549 ENCSR000BRB.CREB1.A-549 119 bp overlap

CREBBP 1 dataset

ChIP fibroblast_proliferating GSE106146.CREBBP.fibroblast_proliferating 299 bp overlap

CTBP2 1 dataset

ChIP MCF-7 GSE107013.CTBP2.MCF-7 111 bp overlap

E2F7 1 dataset

ChIP IMR-90_QUIES GSE40343.E2F7.IMR-90_QUIES 268 bp overlap

EED 1 dataset

ChIP ProEs GSE59087.EED.ProEs 174 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 189 bp overlap

EP300 2 datasets

ChIP fibroblast_proliferating GSE106146.EP300.fibroblast_proliferating 420 bp overlap

ChIP fibroblast_senescent GSE106146.EP300.fibroblast_senescent 269 bp overlap

ESR1 1 dataset

ChIP MCF-7_jc5855 GSE126004.ESR1.MCF-7_jc5855 203 bp overlap

FOS 1 dataset

ChIP IMR-90 ENCSR124AIG.FOS.IMR-90 246 bp overlap

FOSB 2 datasets

ChIP A-549 ENCSR918GHT.FOSB.A-549 484 bp overlap

ChIP A549 ENCFF029EEU 341 bp overlap

FOSL2 3 datasets

ChIP Hep-G2 ENCSR000BHP.FOSL2.Hep-G2 223 bp overlap

ChIP Hep-G2 ENCSR000BHP.FOSL2.Hep-G2 220 bp overlap

ChIP HepG2 ENCFF796NIA 154 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 478 bp overlap

ChIP DE DE-FOXA2-2 111 bp overlap

ChIP DE DE-FOXA2-2 584 bp overlap

FOXD3 1 dataset

Motif DE_60h DE_60h-FOXD3_MA0041.3 14 bp overlap

FOXF1 2 datasets

ChIP GIST-T1 GSE106624.FOXF1.GIST-T1 326 bp overlap

ChIP GIST48 GSE106624.FOXF1.GIST48 436 bp overlap

FOXL2 2 datasets

ChIP HGrC1_C134W-TGF GSE138496.FOXL2.HGrC1_C134W-TGF 322 bp overlap

ChIP HGrC1_C134W-TGF_parental GSE138496.FOXL2.HGrC1_C134W-TGF_parental 213 bp overlap

GATA2 2 datasets

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap

GATA4 6 datasets

ChIP DE DE-GATA4-1 824 bp overlap

ChIP DE DE-GATA4-2 824 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 671 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 749 bp overlap

GATA6 12 datasets

ChIP DE DE-GATA6-1 821 bp overlap

ChIP DE DE-GATA6-2 824 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 483 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 631 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 792 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 714 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 500 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 824 bp overlap

ChIP foregut GSE117136.GATA6.foregut 584 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 434 bp overlap

Gata3 2 datasets

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

HAND2 1 dataset

Motif DE_60h DE_60h-HAND2_MA1638.2 6 bp overlap

HDAC2 2 datasets

ChIP RH4_DMSO-6H GSE116344.HDAC2.RH4_DMSO-6H 205 bp overlap

ChIP RH4_Entinostat-6H GSE116344.HDAC2.RH4_Entinostat-6H 230 bp overlap

HIF1A 1 dataset

ChIP U2OS_DMSO GSE85096.HIF1A.U2OS_DMSO 236 bp overlap

HLF 1 dataset

ChIP HepG2 ENCFF854JLR 245 bp overlap

HMGB2 2 datasets

ChIP IMR-90_proliferating GSE98245.HMGB2.IMR-90_proliferating 332 bp overlap

ChIP IMR-90_proliferating GSE98245.HMGB2.IMR-90_proliferating 213 bp overlap

HOXA7 2 datasets

ChIP A-549 ENCSR402OYZ.HOXA7.A-549 159 bp overlap

ChIP A549 ENCFF746ZBJ 331 bp overlap

HOXB4 1 dataset

Motif DE_60h DE_60h-HOXB4_MA1499.2 6 bp overlap

HOXC4 1 dataset

Motif DE_60h DE_60h-HOXC4_MA1504.2 6 bp overlap

HOXD3 1 dataset

Motif DE_60h DE_60h-HOXD3_MA0912.2 8 bp overlap

HOXD4 1 dataset

Motif DE_60h DE_60h-HOXD4_MA1507.2 6 bp overlap

IFNA1 1 dataset

ChIP Huh-7_GFP GSE110511.IFNA1.Huh-7_GFP 120 bp overlap

JUN 1 dataset

ChIP DE_D2 S02-DE-d2-JUN-exp1 292 bp overlap

JUND 2 datasets

ChIP HT29_DSMO GSE77039.JUND.HT29_DSMO 824 bp overlap

ChIP liver ENCSR196HGZ.JUND.liver 216 bp overlap

KLF6 1 dataset

ChIP PDAC GSE64557.KLF6.PDAC 224 bp overlap

Lhx1 1 dataset

Motif DE_60h DE_60h-Lhx1_MA1518.3 10 bp overlap

MEN1 2 datasets

ChIP HCT-116_B1 GSE152144.MEN1.HCT-116_B1 259 bp overlap

ChIP HCT-116_B1 GSE152144.MEN1.HCT-116_B1 277 bp overlap

MPHOSPH8 1 dataset

ChIP H9 GSE95374.MPHOSPH8.H9 287 bp overlap

MTA2 1 dataset

ChIP RH4 GSE155861.MTA2.RH4 656 bp overlap

MXI1 1 dataset

ChIP IMR-90 ENCSR000EFE.MXI1.IMR-90 129 bp overlap

MYOD1 1 dataset

ChIP RH4 GSE83726.MYOD1.RH4 195 bp overlap

NCAPH2 1 dataset

ChIP IMR-90_FLAG_OIS GSE118494.NCAPH2.IMR-90_FLAG_OIS 217 bp overlap

NEUROD1 3 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 241 bp overlap

ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 290 bp overlap

Motif DE_60h DE_60h-NEUROD1_MA1109.2 8 bp overlap

NEUROG2 2 datasets

Motif DE_60h DE_60h-NEUROG2_MA1642.2 7 bp overlap

ChIP MRC-5_NFD_05DPT GSE75910.NEUROG2.MRC-5_NFD_05DPT 268 bp overlap

NHLH1 1 dataset

Motif DE_60h DE_60h-NHLH1_MA0048.3 9 bp overlap

NR1H2 1 dataset

ChIP HT29_GW3965_48H GSE77039.NR1H2.HT29_GW3965_48H 824 bp overlap

NR3C1 2 datasets

ChIP IMR-90 ERP007093.NR3C1.IMR-90 282 bp overlap

ChIP IMR-90_GLUCC ERP007081.NR3C1.IMR-90_GLUCC 254 bp overlap

Neurod2 2 datasets

Motif DE_60h DE_60h-Neurod2_MA0668.3 8 bp overlap

Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap

Olig2 1 dataset

Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap

PAF1 1 dataset

ChIP HCT-116_ab20662 GSE97527.PAF1.HCT-116_ab20662 167 bp overlap

PAX3-FOXO1 1 dataset

ChIP RH4 GSE140115.PAX3-FOXO1.RH4 206 bp overlap

PCBP2 1 dataset

ChIP Hep-G2 GSE120104.PCBP2.Hep-G2 201 bp overlap

POLR2A 3 datasets

ChIP erythroblast ENCFF498VMR 717 bp overlap

ChIP erythroblast ENCFF498VMR 518 bp overlap

ChIP sigmoid colon ENCFF725QFT 417 bp overlap

POLR2G 2 datasets

ChIP HepG2 ENCFF241AEG 824 bp overlap

ChIP HepG2 ENCFF508UTS 824 bp overlap

POU6F1 1 dataset

Motif DE_60h DE_60h-POU6F1_MA1549.2 7 bp overlap

POU6F2 1 dataset

Motif DE_60h DE_60h-POU6F2_MA0793.2 9 bp overlap

Ptf1A 1 dataset

Motif DE_60h DE_60h-Ptf1A_MA1618.2 9 bp overlap

RAD21 4 datasets

ChIP MDM_-dNS1 GSE103477.RAD21.MDM_-dNS1 430 bp overlap

ChIP MDM_-dNS1 GSE103477.RAD21.MDM_-dNS1 312 bp overlap

ChIP RH4 GSE83726.RAD21.RH4 156 bp overlap

ChIP THP-1_PMA_Dex-6h GSE103477.RAD21.THP-1_PMA_Dex-6h 569 bp overlap

RBM22 2 datasets

ChIP HepG2 ENCFF292RVQ 326 bp overlap

ChIP HepG2 ENCFF561IAJ 303 bp overlap

RCOR1 2 datasets

ChIP IMR-90 ENCFF644MZN 337 bp overlap

ChIP IMR-90 ENCSR000EFG.RCOR1.IMR-90 271 bp overlap

RFX5 1 dataset

ChIP IMR-90 ENCSR000EFD.RFX5.IMR-90 139 bp overlap

SMAD2-3 2 datasets

ChIP HGrC1_C134W-TGF GSE138496.SMAD2-3.HGrC1_C134W-TGF 135 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 791 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 583 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 284 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 624 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 257 bp overlap

SOX8 1 dataset

ChIP RH4 GSE116344.SOX8.RH4 281 bp overlap

SRF 1 dataset

ChIP K-562 ENCSR000BLK.SRF.K-562 114 bp overlap

SRSF4 2 datasets

ChIP Hep-G2 GSE120104.SRSF4.Hep-G2 130 bp overlap

ChIP Hep-G2 GSE120104.SRSF4.Hep-G2 337 bp overlap

STAT1 3 datasets

ChIP CD14_INFG_LPS GSE43036.STAT1.CD14_INFG_LPS 185 bp overlap

Motif DE_48h DE_48h-STAT1_MA0137.4 9 bp overlap

Motif DE_60h DE_60h-STAT1_MA0137.4 9 bp overlap

STAT3 2 datasets

Motif DE_48h DE_48h-STAT3_MA0144.3 9 bp overlap

Motif DE_60h DE_60h-STAT3_MA0144.3 9 bp overlap

SUPT5H 2 datasets

ChIP HeLa GSE125534.SUPT5H.HeLa 182 bp overlap

ChIP HeLa_DOX GSE125534.SUPT5H.HeLa_DOX 318 bp overlap

Stat2 1 dataset

Motif DE_60h DE_60h-Stat2_MA1623.2 10 bp overlap

Stat4 2 datasets

Motif DE_48h DE_48h-Stat4_MA0518.2 10 bp overlap

Motif DE_60h DE_60h-Stat4_MA0518.2 10 bp overlap

Stat5a::Stat5b 2 datasets

Motif DE_48h DE_48h-Stat5aStat5b_MA0519.2 9 bp overlap

Motif DE_60h DE_60h-Stat5aStat5b_MA0519.2 9 bp overlap

Stat5b 2 datasets

Motif DE_48h DE_48h-Stat5b_MA1625.2 9 bp overlap

Motif DE_60h DE_60h-Stat5b_MA1625.2 9 bp overlap

TAL1::TCF3 1 dataset

Motif DE_60h DE_60h-TAL1TCF3_MA0091.2 10 bp overlap

TFAP4 1 dataset

Motif DE_60h DE_60h-TFAP4_MA0691.1 10 bp overlap

TFAP4::FLI1 1 dataset

Motif DE_60h DE_60h-TFAP4FLI1_MA1967.2 14 bp overlap

TRPS1 2 datasets

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Tcf12 1 dataset

Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap

Twist2 1 dataset

Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap

ZBTB33 3 datasets

ChIP HepG2 ENCFF778UKV 150 bp overlap

ChIP K-562 ENCSR876GXA.ZBTB33.K-562 350 bp overlap

ChIP K562 ENCFF875HLX 465 bp overlap

ZBTB7A 1 dataset

ChIP HUDEP-2 GSE103445.ZBTB7A.HUDEP-2 218 bp overlap

ZIM3 1 dataset

Motif DE_60h DE_60h-ZIM3_MA1709.2 11 bp overlap

ZMYND11 1 dataset

ChIP DU145_ETS1KO GSE86238.ZMYND11.DU145_ETS1KO 317 bp overlap

ZNF558 1 dataset

Motif DE_60h DE_60h-ZNF558_MA2335.1 29 bp overlap

ZNF766 1 dataset

ChIP HEK293T GSE78099.ZNF766.HEK293T 107 bp overlap

ZSCAN5C 1 dataset

ChIP HEK293 ENCSR731AGO.ZSCAN5C.HEK293 201 bp overlap