This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FOXF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:86,505,591–86,505,881 | 4.6 kb | Proximal (<10kb) | 96 | |
| chr16:86,508,009–86,508,953 | 1.6 kb | Proximal (<10kb) | 202 | |
| chr16:86,509,426–86,510,903 | at TSS | At TSS | 411 | |
| chr16:86,517,781–86,517,963 | 7.3 kb | Proximal (<10kb) | 250 | |
| chr16:86,520,164–86,520,342 | 9.6 kb | Proximal (<10kb) | 258 |
Genomic view of the FOXF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.