Enables RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome. Located in nuclear speck. Biomarker of Down syndrome; acute myeloid leukemia; clear cell renal cell carcinoma; and colon adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SRSF4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRSF4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRSF4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:28,881,894–28,882,433 | 299.6 kb | Distal (>10kb) Multiome | 615 | |
| chr1:28,886,723–28,888,425 | 293.7 kb | Distal (>10kb) Multiome | 709 | |
| chr1:28,913,920–28,915,470 | 267.4 kb | Distal (>10kb) Multiome | 738 | |
| chr1:29,120,877–29,125,914 | 59.5 kb | Distal (>10kb) Multiome | 782 | |
| chr1:29,181,113–29,182,382 | 84 bp | At TSS Multiome | 1028 | |
| chr1:29,186,756–29,187,081 | 4.9 kb | Proximal (<10kb) | 78 | |
| chr1:29,230,591–29,231,321 | 49.1 kb | Distal (>10kb) Multiome | 779 | |
| chr1:29,236,103–29,236,982 | 54.6 kb | Distal (>10kb) Multiome | 621 | |
| chr1:29,249,179–29,249,843 | 67.5 kb | Distal (>10kb) Multiome | 238 | |
| chr1:29,259,283–29,260,756 | 78.2 kb | Distal (>10kb) Multiome | 310 | |
| chr1:29,282,701–29,284,079 | 101.4 kb | Distal (>10kb) Multiome | 308 | |
| chr1:29,324,465–29,325,612 | 143.1 kb | Distal (>10kb) Multiome | 180 | |
| chr1:30,717,727–30,719,875 | 1536.5 kb | Distal (>10kb) Multiome HiCAR | 1003 |
Genomic view of the SRSF4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.