This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Transcription factors with Perturb-seq knockdown data for ELOVL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELOVL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELOVL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:53,061,219–53,062,138 | 287.1 kb | Distal (>10kb) Multiome | 961 | |
| chr6:53,064,550–53,066,422 | 283.9 kb | Distal (>10kb) Multiome | 934 | |
| chr6:53,347,548–53,349,468 | 790 bp | At TSS Multiome | 976 | |
| chr6:53,358,501–53,360,085 | 10.5 kb | Distal (>10kb) Multiome | 1019 | |
| chr6:53,369,414–53,370,641 | 21.0 kb | Distal (>10kb) Multiome | 168 | |
| chr6:53,495,283–53,496,107 | 146.8 kb | Distal (>10kb) Multiome | 93 | |
| chr6:53,542,102–53,543,184 | 193.7 kb | Distal (>10kb) Multiome | 162 | |
| chr6:53,543,445–53,545,523 | 196.0 kb | Distal (>10kb) Multiome | 1007 | |
| chr6:53,547,468–53,548,755 | 199.2 kb | Distal (>10kb) Multiome | 1074 |
Genomic view of the ELOVL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.