DE-9

Supermodule 326 genes

Signal transduction and cell-cell adhesion machinery

This 338-gene module contains TP53, TGFB1, STAT3, ERBB2, and CDH1, with enrichment in molecular transducer activity, signaling receptor activity, cell-cell adhesion, and transmembrane signaling receptor activity. Knockdown of SOX17, HES1, DNAJC19, MARS, and ZNF787 activates this module. Knockdown of ARID1A, SMARCC1, ZIC3, CTBP1, and CNBP represses this module.

Key terms: multicellular organismal process system development multicellular organism development anatomical structure development developmental process Notable genes: TP53 TGFB1 STAT3 ERBB2 CDH1 HLA-A ITGB1 NR3C1 Top TFs: ARID1A DNAJC19 SMARCC1 SOX17 CNBP

TF Regulatory Network

Direction indicates the effect of TF knockdown on this module (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	#gRNA	padj	Bind	OR

Submodules (8)

Finer-grained co-expression clusters within this supermodule, each with a distinct functional signature.

Submodule	Genes	Notable genes
DE-9.1	54	ERBB2 CDH1 POU5F1 DNMT3B RYR2
DE-9.2	52	NRG1 VIM BMP4 NRP1 FSHR
DE-9.3	24	PTCH1 OPA1 PRKD1 PPP2R2B SLC20A2
DE-9.4	16	MT-ATP6 PLCG2 MT-ND4 MT-ND2 MT-CO1
DE-9.5	14	CADM1 SLIT2 ETV1 VAV3 GRIK2
DE-9.6	13	FKBP5 IGFBP2 TGFBR3 EPHA7 CAMK1D
DE-9.7	11	TGFB1 ITGB1 TNFRSF10B ADAMTS9 IGFBP4
DE-9.8	10	PRKG1 SYT1 NFIA ITPR2 BNC2

Module Genes

All genes assigned to this co-expression supermodule.

Gene	Type	Submodule	Publications

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).